Protein S (Alpha) Proteins (PROS1)

PROS1 encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. Additionally we are shipping PROS1 Antibodies (101) and PROS1 Kits (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PROS1 5627 P07225
PROS1 19128 Q08761
PROS1 81750  
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Top PROS1 Proteins at

Showing 9 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Yeast Rat His tag Protein S (Alpha) (PROS1) (AA 42-675) protein (His tag) expressed in mammalien cells 1 mg Log in to see 60 to 71 Days
HOST_Human Cells Human His tag 100 μg Log in to see 20 to 21 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Log in to see 11 Days
HOST_Escherichia coli (E. coli) Rat GST tag   50 μg Log in to see 11 Days
HOST_Mammalian Cells Rat His tag   20 μg Log in to see 2 to 3 Days

PROS1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine)

Rat (Rattus) , ,

Top referenced PROS1 Proteins

  1. Human PROS1 Protein expressed in HEK-293 Cells - ABIN2729817 : Kariolis, Miao, Jones, Kapur, Mathews, Giaccia, Cochran: An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis. in Nature chemical biology 2014 (PubMed)

More Proteins for Protein S (Alpha) (PROS1) Interaction Partners

Human Protein S (Alpha) (PROS1) interaction partners

  1. we identify PROS1 as a driver of Oral Squamous Cell Carcinoma tumor growth and a modulator of AXL (show AXL Proteins) expression

  2. The prevalence of PS de fi ciency in the present study was higher than in Western countries and con (show DISP1 Proteins) fi rms the high prevalence of PS de fi ciency in Asian populations

  3. Patients with type 2 diabetes had significantly lower circulating free protein S than healthy control subjects

  4. In the present study, gene analysis of six unrelated Japanese families diagnosed with congenital protein S deficiency identified five missense mutations in the PROS1 gene - c.757C>T (Ala139Val; A139V), c.1346 G>T (Cys449Phe; C449F), c.1352G>A (Arg451Gln; R451Q), c.1424G>T (Cys475Phe; C475F) and c.1574C>T (Ala525Val; A525V) - and one frameshift mutation, c.2135delA (Asp599ThrfsTer13; D599TfsTer13).

  5. The odds ratio of developing idiopathic fatal pulmonary embolism as a variant carrier for PROS1 is 56.4 (95% CI, 5.3-351.1; P = 0.001).

  6. described a novel PROS1 frameshift mutation, c.74dupA, in a hereditary protein S deficiency family. Interestingly, both of the proband and his mother carried the mutation and had a protein S deficiency, however, only the proband suffered a pulmonary embolism while his mother had no history of any thrombosis, suggesting that a triggering event might have been involved in the thrombus formation.

  7. PROS1 may play an important role in the development of glioblastoma multiforme through cellular proliferation, migration and invasion as well as apoptosis.

  8. analysis of genotype phenotype correlation in PROS1 in a large cohort of adults with suspicion of inherited quantitative protein S deficiency

  9. The immunoabsorption of PON1 (show PON1 Proteins) from plasma significantly reduced protein S anti-coagulant activity.

  10. A PROS1 c.1486_1490delGATTA mutation on exon 12. appeared to be the primary cause of thrombosis in the family of the present study.

Cow (Bovine) Protein S (Alpha) (PROS1) interaction partners

  1. Activated protein C (show PROC Proteins)(APC (show APC Proteins)) combined with protein S(PS) had significant antithrombotic effect. APC (show APC Proteins) combined with PS prolonged clotting time. Dependence on APC (show APC Proteins)-cofactor activity of PS for expression of anticoagulant activity by APC (show APC Proteins).

Mouse (Murine) Protein S (Alpha) (PROS1) interaction partners

  1. Mice overexpressing protein S showed significant improvements in blood glucose level, glucose tolerance, insulin (show INS Proteins) sensitivity, and insulin (show INS Proteins) secretion compared with wild-type counterparts. diabetic protein S transgenic mice developed significantly less severe diabetic glomerulosclerosis than controls.

  2. By revealing that neural stem-like cells act within the SVZ neurogenic niche as phagocytes and that the ProS/MerTK (show MERTK Proteins) path represents an endogenous regulatory mechanism for SVZ cell phagocytic activity

  3. Optimal TAM (show CCNA1 Proteins) signaling requires coincident TAM (show CCNA1 Proteins) ligand engagement of both its receptor and the phospholipid phosphatidylserine regulating TAM (show CCNA1 Proteins) receptor tyrosine kinases Tyro3 (show TYRO3 Proteins), Axl (show AXL Proteins), and Mer (show ERH Proteins) and their ligands Gas6 (show GAS6 Proteins) and Protein S.

  4. Data indicate that activated T cells express Pros1.

  5. Results demonstrate that Protein S is a Mer (show ERH Proteins) ligand, and is active in Mer (show ERH Proteins)-driven phagocytosis in the retina.

  6. A self-regulatory mechanism of Toll (show TLR4 Proteins)-like receptor signalling through the suppression of Gas6 (show GAS6 Proteins) and ProS expression is described.

  7. Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM (show CCNA1 Proteins) receptor Tyro3 (show TYRO3 Proteins) and sphingosine 1-phosphate receptor1.

  8. results demonstrate that ProS is a pleiotropic anticoagulant with activated Protein C (show PROC Proteins)-independent activities and highlight new roles for ProS in vascular development and homeostasis

  9. Pregnancy causes a decrease in APC (show APC Proteins) resistance in mice, which can be explained by the elevation of protein S levels and increased TFPI (show TFPI Proteins) activity in plasma.

PROS1 Protein Profile

Protein Summary

This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3.

Gene names and symbols associated with Protein S (Alpha) Proteins (PROS1)

  • protein S (alpha) (pros1)
  • protein S (alpha) (PROS1)
  • protein S (alpha) (Pros1)
  • AW214361 protein
  • PROS protein
  • PS21 protein
  • PS22 protein
  • PS23 protein
  • PS24 protein
  • PS25 protein
  • PSA protein
  • THPH5 protein
  • THPH6 protein
  • zgc:154001 protein

Protein level used designations for Protein S (Alpha) Proteins (PROS1)

vitamin K-dependent protein S , protein Sa , vitamin K-dependent plasma protein S , vitamin K-dependent protein S preproprotein

768180 Danio rerio
5627 Homo sapiens
397388 Sus scrofa
282006 Bos taurus
100009314 Oryctolagus cuniculus
19128 Mus musculus
81750 Rattus norvegicus
694845 Macaca mulatta
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