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Protein S (Alpha) Proteins (PROS1)

PROS1 encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. Additionally we are shipping PROS1 Antibodies (73) and PROS1 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PROS1 5627 P07225
PROS1 19128 Q08761
PROS1 81750  
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Top PROS1 Proteins at

Showing 8 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
Yeast Rat His tag Protein S (Alpha) (PROS1) (AA 42-675) protein (His tag) expressed in mammalien cells 1 mg Log in to see 56 to 66 Days
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Rat GST tag   50 μg Log in to see 11 Days
HOST_Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Log in to see 11 Days
HOST_Mammalian Cells Rat His tag   20 μg Log in to see 2 to 3 Days

PROS1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Rat (Rattus) , ,

More Proteins for Protein S (Alpha) (PROS1) Interaction Partners

Human Protein S (Alpha) (PROS1) interaction partners

  1. In the present study, gene analysis of six unrelated Japanese families diagnosed with congenital protein S deficiency identified five missense mutations in the PROS1 gene - c.757C>T (Ala139Val; A139V), c.1346 G>T (Cys449Phe; C449F), c.1352G>A (Arg451Gln; R451Q), c.1424G>T (Cys475Phe; C475F) and c.1574C>T (Ala525Val; A525V) - and one frameshift mutation, c.2135delA (Asp599ThrfsTer13; D599TfsTer13).

  2. The odds ratio of developing idiopathic fatal pulmonary embolism as a variant carrier for PROS1 is 56.4 (95% CI, 5.3-351.1; P = 0.001).

  3. described a novel PROS1 frameshift mutation, c.74dupA, in a hereditary protein S deficiency family. Interestingly, both of the proband and his mother carried the mutation and had a protein S deficiency, however, only the proband suffered a pulmonary embolism while his mother had no history of any thrombosis, suggesting that a triggering event might have been involved in the thrombus formation.

  4. PROS1 may play an important role in the development of glioblastoma multiforme through cellular proliferation, migration and invasion as well as apoptosis.

  5. analysis of genotype phenotype correlation in PROS1 in a large cohort of adults with suspicion of inherited quantitative protein S deficiency

  6. The immunoabsorption of PON1 (show PON1 Proteins) from plasma significantly reduced protein S anti-coagulant activity.

  7. A PROS1 c.1486_1490delGATTA mutation on exon 12. appeared to be the primary cause of thrombosis in the family of the present study.

  8. analysis of the amino acid residues in the laminin G domains of protein S involved in tissue factor pathway inhibitor (show TFPI Proteins) interaction

  9. The present study highlights that the GAS6 (show GAS6 Proteins)/ProS-TAM (show CCNA1 Proteins) system correlates in several ways with disease activity in systemic lupus erythematosus

  10. genetic polymorphism affects endogenous thrombin (show F2 Proteins) potential among FV Leiden carriers

Cow (Bovine) Protein S (Alpha) (PROS1) interaction partners

  1. Activated protein C (show PROC Proteins)(APC (show APC Proteins)) combined with protein S(PS) had significant antithrombotic effect. APC (show APC Proteins) combined with PS prolonged clotting time. Dependence on APC (show APC Proteins)-cofactor activity of PS for expression of anticoagulant activity by APC (show APC Proteins).

Mouse (Murine) Protein S (Alpha) (PROS1) interaction partners

  1. By revealing that neural stem-like cells act within the SVZ neurogenic niche as phagocytes and that the ProS/MerTK (show MERTK Proteins) path represents an endogenous regulatory mechanism for SVZ cell phagocytic activity

  2. Optimal TAM (show CCNA1 Proteins) signaling requires coincident TAM (show CCNA1 Proteins) ligand engagement of both its receptor and the phospholipid phosphatidylserine regulating TAM (show CCNA1 Proteins) receptor tyrosine kinases Tyro3 (show TYRO3 Proteins), Axl (show AXL Proteins), and Mer (show ERH Proteins) and their ligands Gas6 (show GAS6 Proteins) and Protein S.

  3. Data indicate that activated T cells express Pros1.

  4. Results demonstrate that Protein S is a Mer (show ERH Proteins) ligand, and is active in Mer (show ERH Proteins)-driven phagocytosis in the retina.

  5. A self-regulatory mechanism of Toll (show TLR4 Proteins)-like receptor signalling through the suppression of Gas6 (show GAS6 Proteins) and ProS expression is described.

  6. Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM (show CCNA1 Proteins) receptor Tyro3 (show TYRO3 Proteins) and sphingosine 1-phosphate receptor1.

  7. results demonstrate that ProS is a pleiotropic anticoagulant with activated Protein C (show PROC Proteins)-independent activities and highlight new roles for ProS in vascular development and homeostasis

  8. Pregnancy causes a decrease in APC (show APC Proteins) resistance in mice, which can be explained by the elevation of protein S levels and increased TFPI (show TFPI Proteins) activity in plasma.

PROS1 Protein Profile

Protein Summary

This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3.

Gene names and symbols associated with Protein S (Alpha) Proteins (PROS1)

  • protein S (alpha) (pros1)
  • protein S (alpha) (PROS1)
  • protein S (alpha) (Pros1)
  • AW214361 protein
  • PROS protein
  • PS21 protein
  • PS22 protein
  • PS23 protein
  • PS24 protein
  • PS25 protein
  • PSA protein
  • THPH5 protein
  • THPH6 protein
  • zgc:154001 protein

Protein level used designations for Protein S (Alpha) Proteins (PROS1)

vitamin K-dependent protein S , protein Sa , vitamin K-dependent plasma protein S , vitamin K-dependent protein S preproprotein

768180 Danio rerio
5627 Homo sapiens
397388 Sus scrofa
282006 Bos taurus
100009314 Oryctolagus cuniculus
19128 Mus musculus
81750 Rattus norvegicus
694845 Macaca mulatta
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