anti-Protein Tyrosine Phosphatase G1 (PTPN12) Antibodies

The protein encoded by PTPN12 is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping PTPN12 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PTPN12 5782 Q05209
PTPN12 19248 P35831
PTPN12 117255  
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Top anti-PTPN12 Antibodies at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-PTPN12 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>HT1080 cell lysate WB Suggested Anti-PTPN12 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500 <br /> Positive Control: HT1080 cell lysate <br /> PTPN12 is strongly supported by BioGPS gene expression data to be expressed in Human HT1080 cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB Host: Rabbit <br /> Target Name: Ptpn12 <br /> Sample Tissue: Rat Thymus lysates <br /> Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Guinea Pig Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: PTPN12 Antibody [NBP1-87188] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp Immunohistochemistry-Paraffin: PTPN12 Antibody [NBP1-87188] - Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Western Blot and Immunoprecipitation: PTPN12/PTP-PEST Antibody [ABIN253137] - Detection of Human and Mouse PTPN12/PTP-PEST by Western Blot (h&m) and Immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) and mouse NIH3T3 (M, 50 mcg) cells. Antibodies: Affinity purified rabbit anti-PTPN12/PTP-PEST antibody ABIN253137 used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. PTPN12/PTPPEST was also immunoprecipitated by rabbit anti-PTPN12/PTPPEST antibodies ABIN253134, ABIN253135, and ABIN253136 which recognize upstream epitopes.  Detection: Chemiluminescence with exposure times of 30 seconds (A) and 3 seconds (B). Immunohistochemistry-Paraffin: PTPN12 Antibody [ABIN2531376] - Sample: FFPE section of human colon carcinoma. Antibody used at a dilution of 1:250. 0.1 mL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded D54 xenograft, using PTPN12, antibody at 1:500 dilution. ICC/IF Image Immunofluorescence analysis of methanol-fixed HeLa, using PTPN12, antibody at 1:200 dilution. 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$566.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: PTPN12 Antibody [NBP2-20004] - Immunohistochemical analysis of paraffin-embedded D54 xenograft, using antibody at 1:500 dilution. Western Blot: PTPN12 Antibody [NBP2-20004] - Sample (30 ug of whole cell lysate) A: HeLa 5% SDS PAGE gel, diluted at 1:5000. 0.1 mL Log in to see 8 to 11 Days
$447.56
Details
Human Rabbit Un-conjugated WB PTPN12 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 2 to 3 Days
$473.93
Details

PTPN12 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
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Top referenced anti-PTPN12 Antibodies

  1. Human Polyclonal PTPN12 Primary Antibody for ICC, IF - ABIN4348590 : Harris, Blaser, Moreno, Treloar, Gorrini, Sasaki, Mason, Knobbe, Rufini, Hallé, Elia, Wakeham, Tremblay, Melino, Done, Mak: PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling. in Oncogene 2014 (PubMed)
    Show all 2 Pubmed References

More Antibodies against PTPN12 Interaction Partners

Human Protein Tyrosine Phosphatase G1 (PTPN12) interaction partners

  1. MyoVa (show MYO5A Antibodies)-Ca(2 (show CA2 Antibodies)+) channel interactions are required for proper long-range axon growth in developing spinal cord in vivo.

  2. PTP-PEST regulates EphA3 (show EPHA3 Antibodies) activation both by affecting cytoskeletal remodelling and through its direct action as a PTP (show SLC25A3 Antibodies) controlling EphA3 (show EPHA3 Antibodies) phosphorylation.

  3. Study suggests that PTPN12 expression is a valuable prognostic biomarker for non-small cell lung cancer.

  4. PTPN12 expression decreases in human renal cell carcinoma (show MOK Antibodies)

  5. The decrease expression of PTPN12 might be important in conferring a more aggressive behavior in NPC (show NPC1 Antibodies). Thus, PTPN12 expression may be used as a novel independent prognostic biomarker for patients with NPC (show NPC1 Antibodies).

  6. PTPN12 is potentially a methylation-silenced TSG (show TWSG1 Antibodies) for breast cancer that may play an important role in breast carcinogenesis and could potentially serve as an independent prognostic factor for invasive breast cancer patients.

  7. Decreased expression of PTPN12 correlates with tumor recurrence and poor survival of patients with hepatocellular carcinoma.

  8. these data suggest that PTP-PEST affects epithelial cell motility by controlling the distribution and phosphorylation of p120 (show HNRNPU Antibodies) and its availability to control Rho GTPase (show RACGAP1 Antibodies) activity.

  9. The involvement of PTPN12 in the antioxidant response of breast cancer cells suggests that PTPN12 may represent a novel therapeutic target for this disease

  10. Overexpression of PTPN12 inhibited proliferation and migration in OSCC cells.

Mouse (Murine) Protein Tyrosine Phosphatase G1 (PTPN12) interaction partners

  1. PTPN12-deficient, ErbB2 (show ERBB2 Antibodies)-dependent breast cancer cells were more resistant to anoikis and had augmented migratory and invasive properties.

  2. Integrin beta 8 and PTP-PEST form protein complexes at the leading edge of migrating cells and balance patterns of Rac1 and Cdc42 (show CDC42 Antibodies) signaling by controlling the subcellular localization and phosphorylation status of Rho GDP dissociation inhibitor 1 (show ARHGDIA Antibodies).

  3. Pyk2 (show PTK2B Antibodies) deregulation played a pivotal role in the migration defect caused by PTPN12 deficiency.

  4. Regulation of the Src kinase-associated phosphoprotein (show SKAP2 Antibodies) 55 homologue by the protein tyrosine phosphatase (show ACP1 Antibodies) PTP-PEST in the control of cell motility.

  5. macrophage fusion is critically dependent on PTP-PEST.

  6. Overexpression of PTP-PEST substantially inhibits lipopolysaccharide (LPS (show TLR4 Antibodies))-induced tyrosine phosphorylation of IkappaB kinase (show CHUK Antibodies) (IKKbeta (show IKBKB Antibodies)) at Tyr188/199 in RAW264.7 cells.

  7. PTP-PEST is a key regulator of integrin-mediated functions in endothelial cells.

  8. the dephosphorylation of Pyk2 (show PTK2B Antibodies) requires dynamin's GTPase (show RACGAP1 Antibodies) activity and is mediated by the tyrosine phosphatase PTP-PEST.

  9. PTP-PEST controls Pyk2 (show PTK2B Antibodies) activity and is a positive regulator of secondary T cell activation.

  10. the paxillin (show PXN Antibodies)-PTP-PEST interaction contributes to integrin signaling

PTPN12 Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with PTPN12

  • protein tyrosine phosphatase, non-receptor type 12 (PTPN12) antibody
  • protein tyrosine phosphatase, non-receptor type 12 (Ptpn12) antibody
  • P19-PTP antibody
  • PTP-P19 antibody
  • PTP-PEST antibody
  • Ptpg1 antibody
  • RKPTP antibody

Protein level used designations for PTPN12

protein-tyrosine phosphatase G1 , tyrosine-protein phosphatase non-receptor type 12 , MPTP-PEST , protein-tyrosine phosphatase P19

GENE ID SPECIES
5782 Homo sapiens
19248 Mus musculus
117255 Rattus norvegicus
531877 Bos taurus
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