PTPN12 antibody

Catalog No. ABIN7075292

Product Details anti-PTPN12 Antibody

Target: PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPN12 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse PTPN12

Application Details

Application Notes: WB (H,M,R) 1: 500-1: 800, IHC/IF (H,M,R) 1:1000-1:3000/1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for PTPN12

Target: PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))

Alternative Name: PTPN12 (PTPN12 Products)

Synonyms: PTP-PEST antibody, PTPG1 antibody, P19-PTP antibody, PTP-P19 antibody, Ptpg1 antibody, RKPTP antibody, protein tyrosine phosphatase, non-receptor type 12 antibody, PTPN12 antibody, Ptpn12 antibody

Background: The PTPN12 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. The PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion. This suggests it has a regulatory role in controlling cell shape and mobility.

Molecular Weight: 110 kDa

Gene ID: 19248

NCBI Accession: NP_035333

UniProt: P35831