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anti-SIX Homeobox 6 (SIX6) Antibodies

The protein encoded by SIX6 is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. Additionally we are shipping SIX Homeobox 6 Proteins (5) and SIX Homeobox 6 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIX6 20476 Q9QZ28
SIX6 4990 O95475
SIX6 314221  
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Top anti-SIX Homeobox 6 Antibodies at

Showing 10 out of 32 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-SIX6 Antibody Titration: 0.2-1 ug/mlPositive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from HuvEc/COLO205 cells, using SIX6 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HepG2 cells, using SIX6 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB SIX6 Antibody (Center)  western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the SIX6 antibody detected the SIX6 protein (arrow). 400 μL Log in to see 10 to 11 Days
Bat Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 7 to 9 Days
Chicken Rabbit Un-conjugated IC, IF, WB Immunofluorescent analysis of SIX6 staining in NIH3T3 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Western blot analysis of SIX6 expression in Jurkat (A), NIH3T3 (B) whole cell lysates. 200 μL Log in to see 9 Days
Dog Rabbit Un-conjugated IHC, ELISA, WB 50 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IF, ELISA, WB 100 μL Log in to see 7 to 9 Days
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: Homeobox protein SIX6 Antibody [NBP1-82478] - Staining of human nasopharynx shows strong nuclear positivity in respiratory epithelial cells. Western Blot: Homeobox protein SIX6 Antibody [NBP1-82478] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY416023) 0.1 mL Log in to see 7 to 9 Days
Human Rabbit Un-conjugated IHC, ELISA   50 μg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated ELISA, WB   200 μL Log in to see 7 to 9 Days

SIX6 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)

Human , ,

, , , , ,
Rat (Rattus)

Top referenced anti-SIX Homeobox 6 Antibodies

  1. Chicken Polyclonal SIX6 Primary Antibody for IHC, WB - ABIN2779603 : Aijaz, Clark, Williamson, van Heyningen, Morrison, Fitzpatrick, Collin, Ragge, Christoforou, Brown, Hanson: Absence of SIX6 mutations in microphthalmia, anophthalmia, and coloboma. in Investigative ophthalmology & visual science 2004 (PubMed)

  2. Human Polyclonal SIX6 Primary Antibody for IF, ELISA - ABIN1533566 : Gallardo, Lopez-Rios, Fernaud-Espinosa, Granadino, Sanz, Ramos, Ayuso, Seller, Brunner, Bovolenta, Rodríguez de Córdoba et al.: Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary ... in Genomics 1999 (PubMed)

More Antibodies against SIX Homeobox 6 Interaction Partners

Mouse (Murine) SIX Homeobox 6 (SIX6) interaction partners

  1. SIX3 and SIX6 play distinct but compensatory roles in regulating transcription of gonadotrope-specific genes as gonadotrope cells differentiate.

  2. Six6-null mice display abnormal patterns of circadian behavior.

  3. SoxB1 transcription factors are direct activators of Six6 expression in the ventral forebrain

  4. Six6 plays an important role in the regulation of GnRH expression and hypothalamic control of fertility.

  5. in association with Dach (show DACH1 Antibodies) corepressors, regulates proliferation of retinal and pituitary precursor cells by directly repressing cyclin-dependent kinase (show CDK1 Antibodies) inhibitors, including the p27Kip1 (show CDKN1B Antibodies) promoter

  6. Six 3 and Six 6 are differentially required during forebrain development; gene expression in brain

  7. Results show that Lhx2 (show LHX2 Antibodies) and Pax6 (show PAX6 Antibodies) transcription factors operate in a concerted manner during retinal development to promote transcriptional activation of the Six6 homeobox (show PRRX1 Antibodies)-gene in primitive and mature retinal progenitors.

Human SIX Homeobox 6 (SIX6) interaction partners

  1. study replicated the association of POAG with two SNPs at the SIX1 (show SIX1 Antibodies)-SIX6 locus and demonstrated that SNPs, rs10483727 and rs33912345, are significantly associated with POAG, especially with NTG (show OPA1 Antibodies) in patients aged above 40 years

  2. Six1 (show SIX1 Antibodies) regulates p53 (show TP53 Antibodies) via a dual mechanism involving upregulation of microRNA-27a and downregulation of RPL26 (show RPL26 Antibodies).

  3. Single nucleotide polymorphism in SIX6 gene is associated with primary open angle glaucoma.

  4. SIX6 and/or intraocular pressure promotes primary open-angle glaucoma by directly increasing p16INK4a (show CDKN2A Antibodies) expression.

  5. we report a homozygous missense mutation of SIX6 associated with a unique eye phenotype characterized by optic disc anomalies, macular atrophy, and coloboma of the iris and chorioretina.

  6. Nonglaucomatous individuals with the SIX6 missense variant have reduced RNFL thickness in regions known to be particularly affected in those with glaucoma.

  7. Our results, in combination with previous SIX6 work, lead us to hypothesize that SIX6 risk variants disrupt the development of the neural retina, leading to a reduced number of retinal ganglion cells.

  8. No evidence was found that SIX6 mutations underlie human congenital structural eye malformations.

  9. Six6 and Six2 (show SIX2 Antibodies) differ in their DNA-binding mechanisms and in the consequences of their interaction with protein tyrosine phosphatase (show ACP1 Antibodies) Eyes Absent in Six2 (show SIX2 Antibodies)/6-DNA-binding ability.

  10. BOR (show EYA1 Antibodies) and OAVS features are associated with duplication of SIX1 (show SIX1 Antibodies), SIX6 and OTX2 (show OTX2 Antibodies) resulting from a complex chromosomal rearrangement.

Cow (Bovine) SIX Homeobox 6 (SIX6) interaction partners

  1. a new helix in the C-terminal domain of the mutated bovine SIX6 protein was revealed, which possibly affects pituitary development and hormone secretion

SIX Homeobox 6 (SIX6) Antigen Profile

Protein Summary

The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2).

Gene names and symbols associated with anti-SIX Homeobox 6 (SIX6) Antibodies

  • sine oculis-related homeobox 6 (Six6) antibody
  • sine oculis-related homeobox 6a (six6a) antibody
  • SIX homeobox 6 (six6) antibody
  • SIX homeobox 6 (SIX6) antibody
  • SIX homeobox 6 (Six6) antibody
  • MCOPCT2 antibody
  • MGC63871 antibody
  • OPTX2 antibody
  • Six6 antibody
  • Six6.1 antibody
  • Six6.2 antibody
  • Six9 antibody
  • XOptx2 antibody
  • xSix6 antibody
  • zgc:63871 antibody

Protein level used designations for anti-SIX Homeobox 6 (SIX6) Antibodies

homeobox protein SIX6 , optic homeobox 2 , sine oculis homeobox homolog 6 , sine oculis-related homeobox 6 homolog , sine oculis-related homeobox 6a , homeobox protein Optx2 , homeodomain protein OPTX2

20476 Mus musculus
394080 Danio rerio
398128 Xenopus laevis
395843 Gallus gallus
4990 Homo sapiens
490718 Canis lupus familiaris
539749 Bos taurus
314221 Rattus norvegicus
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