SRY (Sex Determining Region Y)-Box 3 Proteins (SOX3)

SOX3 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. Additionally we are shipping SOX3 Antibodies (70) and SOX3 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SOX3 6658 P41225
SOX3 20675  
Rat SOX3 SOX3 367950  
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Top SOX3 Proteins at

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days
Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days

SOX3 Proteins by Origin and Source

Origin Expressed in Conjugate

Mouse (Murine)

More Proteins for SRY (Sex Determining Region Y)-Box 3 (SOX3) Interaction Partners

Human SRY (Sex Determining Region Y)-Box 3 (SOX3) interaction partners

  1. we provide a first map of the epigenetic landscape of SOX3 in pluripotent cells and during the early phases of neural differentiation. We found SOX3 gene to be non methylated from undifferentiated NT2/D1 to cells committed towards neural lineage.

  2. These findings demonstrate the novel mechanism by which Sox3 contributes to endometrial cancer stem cell invasion and suggest that repression of Sox3 by microRNA-194 may have therapeutic potential to suppress endometrial carcinoma metastasis. The cancer stem cell marker, CD133, might be the surface marker of endometrial cancer stem cell.

  3. Data indicate that SRY-box 3 transcription factor SOX-3 targets Src kinase (show CSK Proteins) in epithelial ovarian cancer (EOC) cells.

  4. SOX3 overdosage permits normal sex development in 46,XX individuals with random X inactivation.

  5. Translocations interrupting this region may also affect the gonadal development, possibly depending on the chromatin context of the recipient chromosome. SOX3 duplications may substitute SRY (show SRY Proteins) in some XX subjects

  6. Screening for SOX3 should be advised not only for hypopituitary patients with an ectopic posterior pituitary, but also for those with a structurally normal pituitary

  7. Our study provides additional evidence that deletion in polyalanine tracts of SOX3 is associated with hypopituitarism

  8. SOX3 duplication is a genetic cause for XH but has incomplete penetrance. Moreover, increased SOX3 levels may be a risk factor for NTD and potentially other clinical characteristics.

  9. the results point at CREB (show CREB1 Proteins) as a positive regulator of SOX3 gene transcription in NT2/D1 cells, while its contribution to RA induction of SOX3 promoter is not prominent.

  10. Overexpression of Sox3 is associated with esophageal squamous cell carcinoma.

Xenopus laevis SRY (Sex Determining Region Y)-Box 3 (SOX3) interaction partners

  1. Sox2 (show SOX2 Proteins) is necessary for spinal cord regeneration and suggest a model whereby spinal cord injury activates proliferation of Sox2 (show SOX2 Proteins)/3 expressing cells and their differentiation into neurons, a mechanism that is lost in non-regenerative froglets.

  2. XSeb4R (show RBM38 Proteins) protein bound specifically to the 3'UTR of Sox3 mRNA. XSeb4R (show RBM38 Proteins) gain-of-function in ectodermal explants revealed increased stability of the maternal Sox3 transcripts, associated with a robust Sox3 protein production.

  3. knockdown of Oct91 inhibits neural induction driven by either Sox2 (show SOX2 Proteins) or Sox3.

  4. Animal pole localized Sox3 acts to inhibit Nodal (Xnr5 and Xnr6) expression, and induces the expression of genes (Ectodermin (show TRIM33 Proteins), Xema (show FOXI1 Proteins), and Coco (show DAND5 Proteins)) whose products repress Nodal signaling.

  5. Results demonstrate that both sox3 and sox2 are induced in response to BMP antagonism, but by distinct mechanisms and that the activation of both genes is independent of FGF signaling; however, both require FGF for the maintenance of their expression.

  6. Eya1 (show EYA1 Proteins) and Six1 (show SIX1 Proteins) are required for both the regulation of placodal neuronal progenitor proliferation, through their effects on SoxB1 expression, and subsequent neuronal differentiation.

Mouse (Murine) SRY (Sex Determining Region Y)-Box 3 (SOX3) interaction partners

  1. CRISPR/Cas9-assisted gene swap provides strong evidence that SOX2 (show SOX2 Proteins) and SOX3 proteins are functionally equivalent in developing brain and testes.

  2. Sox3 null mice exhibit a ventral extension of the anterior pituitary that penetrates, and generates a mass beneath, the sphenoid bone

  3. These data define Dbx1 (show DBX1 Proteins) as a direct SOX3 target gene.

  4. Sox2 (show SOX2 Proteins) and Sox3 play a role in central nervous system glia and provide mechanistic insights into their function during differentiation processes.

  5. findings show SOX3 expression is maintained throughout telencephalic neurogenesis and is restricted to progenitor cells with neuroepithelial and radial glial morphologies; it is expressed within adult neurogenic regions; expression within the developing hypothalamus is upregulated in developing neurons and is maintained in a subset of differentiated hypoththalamic cells

  6. Subcommissural organ function is essential for the prevention of hydrocephalus and overexpression of Sox3 in the dorsal midline alters progenitor cell differentiation in a dose-dependent manner.

  7. It was shown that Sox2 (show SOX2 Proteins) and Sox3 are dose-dependent regulators of sonic hedgehog (show SHH Proteins) transcription that directly bind and activate a long-range Shh (show SHH Proteins) forebrain enhancer.

  8. In neural precursor cells , Sox3 binds genes that are later bound and activated by Sox11 (show SOX11 Proteins) in differentiating neurons (Sox2 (show SOX2 Proteins))

  9. The results indicate that Sox3 functions in an intrinsic manner to promote differentiation of spermatogonia in prepubertal mice but it is not required for ongoing spermatogenesis in adults.

  10. in a transgenic line, Sox3 was ectopically expressed in the bipotential gonad and this led to frequent complete XX male sex reversal

Zebrafish SRY (Sex Determining Region Y)-Box 3 (SOX3) interaction partners

  1. significant decreases in sox3 (up to 3-fold) expression following chilling. Significant increases in expression of sox3 (up to 33-fold) during warming of chilled zebrafish embyos.

  2. Knockdown of fgf24 or sox3 causes severe epibranchial deficiencies but has little effect on otic development

  3. Knockdown of the four B1 sox (show PIPOX Proteins) genes sox2 (show SOX2 Proteins)/3/19a/19b resulted in severe developmental abnormalities.

  4. The pro-neural effects of Sox3 can compensate for inhibition of fibroblast growth factor (Fgf) signalling in inducing neural tissue but it is not sufficient to maintain neural fate, suggesting the presence of Sox3-independent roles of Fgf at later stages.

SOX3 Protein Profile

Protein Summary

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked mental retardation with growth hormone deficiency.

Gene names and symbols associated with SOX3

  • transcription factor SOX-3 (Tsp_06143)
  • SRY (sex determining region Y)-box 3 (sox3)
  • SRY (sex determining region Y)-box 3 (LOC100349101)
  • SRY (sex determining region Y)-box 3 (LOC100349813)
  • SRY (sex determining region Y)-box 3 (SOX3)
  • SRY-box containing gene 3 (Sox3)
  • SRY-box containing gene 3 (sox3)
  • CH3 protein
  • fc93f07 protein
  • GHDX protein
  • id:ibd2036 protein
  • MRGH protein
  • PHP protein
  • PHPX protein
  • sb:cb493 protein
  • Sox-3 protein
  • sox3-a protein
  • SOXB protein
  • Sry protein
  • wu:fc93f07 protein
  • wu:fd02a08 protein
  • Xlsox3 protein
  • xSox-B1 protein
  • xSox3 protein
  • Xtsox3 protein
  • zgc:110279 protein

Protein level used designations for SOX3

transcription factor SOX-3 , transcription factor Sox-3 , SRY (sex determining region Y)-box 3 , SRY-related protein CH3 , cSox3 , transcription factor SOX3 , transcription factor Sox-3-A , xSox3 , 2036

10911545 Trichinella spiralis
493228 Xenopus (Silurana) tropicalis
100349101 Oryctolagus cuniculus
100349813 Oryctolagus cuniculus
6658 Homo sapiens
492178 Canis lupus familiaris
374019 Gallus gallus
399335 Xenopus laevis
781679 Bos taurus
20675 Mus musculus
367950 Rattus norvegicus
30529 Danio rerio
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