SOX3 Protein (AA 1-375) (His tag)

Catalog No. ABIN7563439

This Recombinant SOX3 protein is produced in HEK-293 Cells.

Quick Overview for SOX3 Protein (AA 1-375) (His tag) (ABIN7563439)

Target: SOX3 (SRY (Sex Determining Region Y)-Box 3 (SOX3))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-375

Purification tag / Conjugate: This SOX3 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Sox3 Protein expressed in mammalian cells.

Sequence: MYSLLETELK NPVGPPTPAA GTGVPAAPGA AGKSGANPAG GANAGNGGSG GANGGGGGGG GGGSDQDRVK RPMNAFMVWS RGQRRKMALE NPKMHNSEIS KRLGADWKLL TDAEKRPFID EAKRLRAVHM KEYPDYKYRP RRKTKTLLKK DKYSLPGGLL PPGAAAAAAA AAAAAAASSP VGVGQRLDTY THVNGWANGA YSLVQEQLGY AQPPSMSSPP PPPALPQMHR YDMAGLQYSP MMPPGAQSYM NAAAAAAAAS GYGGMAPSAA AAAAAAYGQQ PATAAAAAAA AAAMSLGPMG SVVKSEPSSP PPAIASHSQR ACLGDLRDMI SMYLPPGGDA ADAASPLPGG RLHGVHQHYQ GAGTAVNGTV PLTHI Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: SOX3 (SRY (Sex Determining Region Y)-Box 3 (SOX3))

Alternative Name: Sox3

Background: Transcription factor SOX-3,FUNCTION: Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. {ECO:0000269|PubMed:14981518, ECO:0000269|PubMed:17728342, ECO:0000269|PubMed:21183788}.

Molecular Weight: 37.8 kDa

UniProt: P53784

AlphaFold: P53784