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Probable transcription factor.. Additionally we are shipping SALL2 Antibodies (28) and SALL2 Kits (6) and many more products for this protein.
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Understanding SALL2 function and the molecular mechanisms governing its expression and activity is critical to comprehend why and how SALL2 could contribute to disease. This knowledge will open new perspectives for the development of molecular targeted approaches in disease
Sall2 enhanced the p16 minigene blocking of cell cycle progression and p16 knockdown with siRNA abolished most of the Sall2 inhibition of cell cycle progression
Mechanisms of silencing SALL2 in OVCA cell lines and primary tumors and possible therapeutic approaches for ovarian carcinoma are discussed in this review.
A role for SALL2 in eye morphogenesis and loss of function of the gene causes ocular coloboma in humans and mice.
The SALL2 P2 promoter is hypermethylated in a majority of serous ovarian carcinomas.
c-MYC may come under negative regulation by p150, consistent with the action of p150 as a putative tumor suppressor.
Here, the authors report that human papillomavirus type 16 E6 targets the cellular factor p150(Sal2), which positively regulates p21(WAF1 (show CDKN1A Proteins)) transcription.
Results demonstrate binding of p150(Sal2) to two natural promoters with GC elements related to the optimal binding sequence defined in vitro and whose regulation is important for suppression of tumor growth.
A CUL4/DDB1 E3 ligase containing RBBP7 (show RBBP7 Proteins) as the p150(Sal2) receptor has been identified as mediating the destruction of p150(Sal2) as cells transition from a quiescent to an actively growing state.
Studies indicate that vertebrate sal orthologues (spalt-like/sall) have important developmental roles during neural development and organogenesis and gentic diseases.
In addition, studies in leukemia Jurkat T cells support the existence of the Sall2/Noxa (show PMAIP1 Proteins) axis, and the significance of this axis on the apoptotic response to doxorubicin in cancer cells.
Data show that p53 (show TP53 Proteins) activation diminished SALL2 RNA and protein levels during genotoxic cellular stress in primary embryo fibroblasts (MEFs).
We have now generated mice lacking Sall2.Mice lacking both Sall1 and Sall2 show kidney phenotypes comparable to those of Sall1 knockout, thereby demonstrating the dispensable roles of Sall2 in embryonic and kidney development
Results suggest that p150(Sal2), acting in part as a p53 (show TP53 Proteins)-independent regulator of p21 and BAX (show BAX Proteins), can function in some cell types as a regulator of cell growth and survival.
These data establish Sall2 as a link between p75 neurotrophin receptor (show NGFR Proteins) and transcriptional events that regulate the growth and development of neuronal cells.
Probable transcription factor.
sal-like protein 2
, zinc finger protein 795
, zinc finger protein SALL2
, zinc finger protein Spalt-2
, spalt-like protein 2