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Secreted phosphoprotein 1 Proteins (SPP1)

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. Additionally we are shipping Osteopontin Antibodies (394) and Osteopontin Kits (112) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPP1 6696 P10451
SPP1 20750 P10923
SPP1 25353 P08721
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Top Osteopontin Proteins at

Showing 10 out of 57 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag Secreted phosphoprotein 1 (SPP1) (AA 17-300), (partial) protein (His t... 50 μg Log in to see 9 to 11 Days
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
HOST_HEK-293 Human Un-conjugated   10 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human GST tag 10% SDS-PAGE stained with Coomassie Blue (CB) and peptide fingerprinti... 100 μg Log in to see 5 to 7 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days

SPP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Top referenced Osteopontin Proteins

  1. Human Osteopontin Protein expressed in HEK-293 - ABIN2666563 : Yokosaki, Tanaka, Higashikawa, Yamashita, Eboshida: Distinct structural requirements for binding of the integrins alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 to osteopontin. in Matrix biology : journal of the International Society for Matrix Biology 2005 (PubMed)
    Show all 5 references for ABIN2666563

  2. Human Osteopontin Protein expressed in Escherichia coli (E. coli) - ABIN1047487 : Kiefer, Bauer, Barr: The cDNA and derived amino acid sequence for human osteopontin. in Nucleic acids research 1989 (PubMed)
    Show all 3 references for ABIN1047487

  3. Human Osteopontin Protein expressed in Escherichia coli (E. coli) - ABIN668040 : Koh, da Silva, Bansal, Bansal, Sun, Lee, Glogauer, Sodek, Zohar: Role of osteopontin in neutrophil function. in Immunology 2007 (PubMed)
    Show all 2 references for ABIN668040

  4. Human Osteopontin Protein expressed in HEK-293 Cells - ABIN2181569 : Christensen, Nielsen, Haselmann, Petersen, Sørensen: Post-translationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and five O-glycosylation sites and their biological implications. in The Biochemical journal 2005 (PubMed)

  5. Human Osteopontin Protein expressed in Human Cells - ABIN2002652 : Nagasaka, Matsue, Matsushima, Aoki, Nakamura, Kambe, Kon, Uede, Shimada: Osteopontin is produced by mast cells and affects IgE-mediated degranulation and migration of mast cells. in European journal of immunology 2008 (PubMed)

More Proteins for Secreted phosphoprotein 1 (SPP1) Interaction Partners

Human Secreted phosphoprotein 1 (SPP1) interaction partners

  1. OPN rs17524488 (-156 GG/G), rs11730582 (-443 T/C), and rs9138 (C/A) polymorphisms may be associated with cancer susceptibility in the Chinese population (Meta-Analysis)

  2. Authors conclude that while all OPN isoforms are frequently co-overexpressed in primary EACs, isoforms OPNb and OPNc enhance invasion and dissemination through collective yet distinct mechanisms.

  3. SPP1 rs4754 polymorphism may be related to risk of fracture, but not rs6840362

  4. High osteopontin level was significantly correlated with advanced Hepatitis B-related Hepatocellular Carcinoma.

  5. Osteopontin serum levels are negatively related to bone mineral density and positively correlated with bone turnover levels in Chinese postmenopausal women.

  6. These findings suggested that OPN might increase influenza virus-induced lung injury by augmenting lung epithelial cell apoptosis and impairing the epithelial sodium channel and extracellular matrix destruction.

  7. RNAi based on different segments of the OPN gene had different down-regulatory effects on OPN expression.

  8. Our results suggest that OPN enhanced chemoresistance of cisplatin in HCC (show FAM126A Proteins) cells by activating PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling pathway, blocking the OPN pathway might be a novel way to overcome the disease

  9. A positive expression of OPN predicts a poor response and survival in patients with locally advanced stage IVA/B OSCC treated with cisplatin-based IC followed by CCRT.

  10. Using plasma samples from hepatocellular carcinoma patients and liver cirrhosis control patients, plasma AFP (show AFP Proteins), PIVKA-II, OPN and DKK-1 (show DKK1 Proteins) levels were measured. The sensitivity and specificity for OPN biomarker was 46.2% and 80.3% (OPN>100 ng/mL).

Pig (Porcine) Secreted phosphoprotein 1 (SPP1) interaction partners

  1. These data suggested that methylation in the OPN promoter plays a crucial role in the regulation of OPN expression that we found in cloned pigs genome.

  2. The striking breed differences between hyperprolific Large White and Meishanin pigs of secreted phospoprotein 1 expression in endometrium suggest that SPP1 may be associated with placental efficiency.

  3. Microglia incubated in vitro with different concentrations (0.1 fM-1 nM) of recombinant osteopontin showed increased proliferation at 10 fM.

  4. results of this study reveal faster growth rate and differences in pig productivity according to genotypes of the SPP1 gene

  5. Osteopontin could play an important role in the development of neointimal hyperplasia in venous conduits after coronary artery bypass grafting.

  6. A different MSSCP pattern was shown in osteopontin which indicates that mutation is located in promotor region; the A --> G transitions was identified in two positions -617 and -608

  7. The 3' terminal end of the first intron of porcine SPP1 harbors a C/EBPbeta (show CEBPB Proteins) binding site and this binding site is negatively affected by the mutant G allele.

  8. in pregnant pigs SPP1 is induced by conceptus estrogen in uterine luminal epithelium and is regulated in a manner coincident with placental progesterone production

  9. osteopontin promotes pathologic mineralization via calcium pyrophosphate dihydrate crystal formation in articular cartilage.

  10. Osteopontin is detected in the majority of germ cells and is involved in spermatogenesis in boar testis.

Mouse (Murine) Secreted phosphoprotein 1 (SPP1) interaction partners

  1. OPN produced by hematogenous macrophages induces astrocyte process extension toward the infarct border zone, which may contribute to repair of the ischemic neurovascular unit following stroke

  2. During the priming phase of liver regeneration, osteopontin enhances the recruitment of macrophages and neutrophils, and triggers hepatocyte proliferation through Kupffer cell-derived IL-6 (show IL6 Proteins) release and the downstream activation of Stat3 (show STAT3 Proteins).

  3. OPN deficiency accelerated the spontaneous development of colitis in mice with disrupted gut (show GUSB Proteins) microbiota and macrophage phagocytic activity.

  4. mechanical stretch (MS) directly increased OPN protein expression and secretion in vascular smooth muscle cells.

  5. OPN may modulate psoriasis-like inflammation through altering lymphocyte distribution in skin and draining lymph nodes and by inducing IL-17 (show IL17A Proteins) expression of inflammatory T cells.

  6. Osteopontin is expressed in the oviduct and promotes fertilization and preimplantation embryo development.

  7. BSP (show KLK6 Proteins) has a role in mouse cementum and craniofacial bone mineralization

  8. OPN actually contributes to the development of gastric cancer.

  9. Hypergravity promoted OPN expression in osteoblasts by facilitating focal adhesion assembly, strengthening actin bundles, and increasing Runx2 (show RUNX2 Proteins) expression.

  10. lentiviral-OPN short hairpin RNA ameliorates the inflammatory response and bone destruction in mice with collagen-induced arthritis. Therefore, OPN may be a potential therapeutic target for rheumatoid arthritis.

Cow (Bovine) Secreted phosphoprotein 1 (SPP1) interaction partners

  1. This implies that a majority of the acidic residues within OPN must be engaged in calcium interaction under physiological conditions.

  2. Genetic variations in the SPP1 promoter affect gene expression and the level of osteopontin secretion into bovine milk.

  3. Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.

  4. osteopontin (OPN) can serve as a process-directing agent for the intrafibrillar mineralization of collagen.

  5. Results suggest a mechanism of the interaction of UO2(2+) with bone metabolism and a new role for osteopontin (OPN) as a metal transporter.

  6. Upon induction of luteolysis, SPP1 serves as a signaling molecule to recruit or activate immune cells to facilitate luteal regression and tissue degradation.

  7. OPN strongly reduces the amount of biofilm formed in a well-defined laboratory model of acidogenic dental biofilm.

  8. This study demonstrates that adhesion of isolated neonatal rat osteoclasts in vitro was augmented on bovine milk osteopontin (bmOPN) with post-translational modifications (PTMs) compared to human Escherichia-coli-derived recombinant OPN without PTMs.

  9. topographical distribution of both the in vivo and in vitro phosphorylation sites of bone sialoprotein (show CRISP1 Proteins)

  10. the bovine osteopontin gene has two functionally distinct clusters of haplotypes within the QTL region on chromosome 6

Rabbit Secreted phosphoprotein 1 (SPP1) interaction partners

  1. Infection of urinary tract by Escherichia coli caused higher than normal expression of promoter protein osteopontin and mucosal damage at renal tubular cells.

Osteopontin (SPP1) Protein Profile

Protein Summary

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000

Gene names and symbols associated with SPP1

  • secreted phosphoprotein 1 (spp1)
  • secreted phosphoprotein 1 (SPP1)
  • secreted phosphoprotein 1 (Spp1)
  • sphingosine-1-phosphate phosphatase 1 (Sgpp1)
  • sphingosine-1-phosphate phosphatase 1 (SGPP1)
  • 2AR protein
  • AI463453 protein
  • Apl-1 protein
  • BNSP protein
  • Bsp protein
  • BSPI protein
  • Eta protein
  • ETA-1 protein
  • OP protein
  • Opn protein
  • Opnl protein
  • OSP protein
  • Ric protein
  • SPP protein
  • Spp-1 protein
  • SPP1 protein
  • SPPase1 protein
  • Spph1 protein
  • zgc:111821 protein

Protein level used designations for SPP1

spp1 protein , osteopontin , SPP1/CALPHA1 fusion , early T-lymphocyte activation 1 , nephropontin , osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein , secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) , urinary stone protein , uropontin , SPP-1 , bone sialoprotein 1 , 44 kDa bone phosphoprotein , calcium oxalate crystal growth inhibitor protein , early T-lymphocyte activation 1 protein , minopontin , osteopontin-like protein , Sialoprotein (osteopontin) , bone sialoprotein I , osteopontin-K , OC-1 , secreted phosphoprotein-1 , SPPase1 , sphingosine-1-phosphatase 1 , hSPP1 , hSPPase1 , spp1

432385 Danio rerio
6696 Homo sapiens
478471 Canis lupus familiaris
397087 Sus scrofa
20750 Mus musculus
25353 Rattus norvegicus
281499 Bos taurus
100008982 Oryctolagus cuniculus
395210 Gallus gallus
443058 Ovis aries
100860805 Capra hircus
81535 Mus musculus
81537 Homo sapiens
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