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SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 6 Antibodies (193) and Sirtuin 6 Proteins (24) and many more products for this protein.
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our data suggest that SIRT6 suppresses glioma cell growth via induction of apoptosis, inhibition of oxidative stress and inhibition of the activation of the JAK2 (show JAK2 ELISA Kits)/STAT3 (show STAT3 ELISA Kits) signaling pathway.
SIRT6 in a protein complex with both nuclear factor erythroid 2-related factor 2 (NRF2 (show NFE2L2 ELISA Kits)) and RNA polymerase II.
These data strongly suggest that overexpression of Sirt6 can prevent osteoarthritis development by reducing both the inflammatory response and chondrocytes senescence.
Findings suggest that polymorphisms in SIRT6/UCP1 (show UCP1 ELISA Kits) genes may be important for increased carotid plaque burden and echodensity
Lamin A (show LMNA ELISA Kits) promotes SIRT6-dependent DNA-PKcs (DNA-PK catalytic subunit (show PRKDC ELISA Kits)) recruitment to chromatin.
demonstrate that PKM2 deacetylation is integral to SIRT6-mediated tumor suppression and inhibition of metastasis. Additionally, reduced SIRT6 levels correlate with elevated nuclear acetylated PKM2 levels in increasing grades of hepatocellular carcinoma
SIRT6 mutations identified in human cancers alter either SIRT6 stability, localization, or enzymatic activity. Deacetylase, not demyristoylase, activity is critical for SIRT6 tumor-suppressor.
These findings therefore provide insights into the functional interplay between SIRT6 and DNA repair mechanisms, with implications for both tumorigenesis and the treatment of multiple myeloma.
These results support a hypothesis whereby RUNX2 (show RUNX2 ELISA Kits)-mediated repression of the SIRT6 tumor suppressor regulates metabolic pathways that promote breast cancer progression
EGF (show EGF ELISA Kits) stimulates loss of FOXO3 (show FOXO3 ELISA Kits)/SIRT6, which is blockaded by the inhibition of upstream pathways as well as lipid synthesis, revealing existence of a negative regulatory loop between LDs and FOXO3 (show FOXO3 ELISA Kits)/SIRT6.
results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (show MAS1 ELISA Kits)) and management in beef cattle breeding programs.
up-regulates AMP (show TMPRSS5 ELISA Kits)/ATP and then activates the AMPK (show PRKAA1 ELISA Kits)-FoxO3alpha axis and further initiates the downstream antioxidant-encoding gene expression, thereby decreasing cellular levels of oxidative stress and mediating cardioprotection in the ischemic heart
SIRT6 is important for glucose-stimulated insulin (show INS ELISA Kits) secretion from pancreatic beta cells and activation of SIRT6 may be useful to improve insulin (show INS ELISA Kits) secretion in diabetes
Sirt6 depletion causes spindle defects and chromosome misalignment during meiosis of mouse oocyte
In SIRT6-deficient mice there is impaired bone remodeling leading to osteopenia.
SIRT6/NF-kappaB (show NFKB1 ELISA Kits) signaling axis in ginsenoside Rg1 (show PPP1R3A ELISA Kits)-delayed hematopoietic stem/progenitor cell senescence.
Data showed the expression levels of SIRT1 (show SIRT1 ELISA Kits), SIRT3 (show SIRT3 ELISA Kits), and SIRT6 were decreased in the ovaries of aged mice and mice treated with chemotherapy, but increased in mice treated to caloric restriction suggesting these genes are closely related to ovarian reserve.
Sodium sulfide protected brain endothelial cells against simulated ischemic injury through SIRT6-dependent mechanisms.
SIRT1 (show SIRT1 ELISA Kits) localizes to the promoters of several aberrantly silenced tumor suppressor genes whose DNA is hypermethylated
Sirt6 has key roles in the relationship among ageing, metabolic syndrome, and osteoarthritis
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.
sirtuin (silent mating type information regulation 2 homolog) 6
, NAD-dependent deacetylase sirtuin-6
, NAD-dependent protein deacetylase sirtuin-6
, SIR2-like protein 6
, regulatory protein SIR2 homolog 6
, sir2-related protein type 6
, sirtuin type 6