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The protein encoded by SP1 is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. Additionally we are shipping SP1 Antibodies (237) and SP1 Kits (20) and many more products for this protein.
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A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (show ATP7A Proteins), sp1 and sod1 (show SOD1 Proteins) in zebrafish.
zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
miR (show MLXIP Proteins)-326 can restore CDDP chemosensitivity in the human lung adenocarcinoma cells by targeting SP1 (show PSG1 Proteins), and HOTAIR upregulate the expression of miR (show MLXIP Proteins)-326 target gene SP1 (show PSG1 Proteins).
TEAD1 (show TEAD1 Proteins) could enhance the expression levels of SP1 (show PSG1 Proteins), by directly binding to its promoter.
site-directed mutagenesis of potential SP1 (show PSG1 Proteins) binding sites diminished both DNA-protein complexes and SP1 (show PSG1 Proteins)-mediated upregulation of URG-4 (show URGCP Proteins) promoter activity. These findings are valuable for understanding transcriptional regulation of URG4/URGCP (show URGCP Proteins) that has a pivotal role in cancer progression.
Sp1 (show PSG1 Proteins) up-regulated TMEPAI (show PMEPA1 Proteins) protein expression, as well as Sp1 (show PSG1 Proteins) promoting TMEPAI (show PMEPA1 Proteins)-induced cell proliferation.
the results of this study suggest that the miR (show MLXIP Proteins)-24/SP1 (show PSG1 Proteins) pathway contributed to the reduction in radioresistance in human NPC (show NPC1 Proteins) and that it may thus represent a therapeutic target.
we predicted CG-rich region of miR (show MLXIP Proteins)-23a-27a-24-2 cluster (miR (show MLXIP Proteins)-23a, miR (show MLXIP Proteins)-27a, and miR (show MLXIP Proteins)-24-2)promoter and detected the methylation status in the region spanning two SP1 (show PSG1 Proteins) sites.
Bioinformatics analysis demonstrated that SP1 (show PSG1 Proteins) represented a common transcription factor associated with changes in metastasis-related factors. Blocking SP1 (show PSG1 Proteins) activity by an inhibitor suppressed the starvation-plus-radiation treatment-mediated enhancement of U251 cell metastasis.
Results provide evidence that Sp1 (show PSG1 Proteins) positively controls TIAM2S transcription and that Sp1 (show PSG1 Proteins)-mediated transcriptional activation is essential for TIAM2S ectopic expression in liver cancer cells.
The growth-inhibitory effects of mithramycin in malignant pleural mesotheliomas cells were recapitulated by combined SP1 (show PSG1 Proteins) knockdown/p53 (show TP53 Proteins) overexpression
results suggest that Sp1 (show PSG1 Proteins) is an anti-senescence transcription factor in the telomere uncapping-induced senescence and that down-regulation of Sp1 (show PSG1 Proteins) leads to the senescence via down-regulation of the nuclear transport
study demonstrates the co-expression of DLX3 (show DLX3 Proteins), PPARG (show PPARG Proteins) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
likely involvement of the Sp family in regulating PTH (show PTH Proteins) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.
The coordinate regulation of the bovine PRNP (show PRNP Proteins) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (show PRNP Proteins) promoter and its activity.
miR (show MLXIP Proteins)-124, -128, and -137 act synergistically to regulate Sp1 expression.
YY1 (show YY1 Proteins) and SP1 independently and cooperatively govern the Mesp1 (show MESP1 Proteins) expression during embryogenesis.
Taken together, these results indicate that the transcription factor Sp1 upregulates the proximal promoter activity of the mouse Col11a1 gene in chondrocytes.
In the initial stage of myocyte differentiation, transcription of the YB-1 (show YBX1 Proteins) gene was regulated by E2F1 (show E2F1 Proteins) and Sp1, and was then gradually replaced under the control of both MyoD (show MYOD1 Proteins) and myogenin (show MYOG Proteins).
Data indicate that Sp1 and AP-1 (show JUN Proteins)-related factors are involved in the regulation of MFG-E8 (show MFGE8 Proteins) gene transcription by targeting their binding sites in the 5'-flanking region under physiological and inflammatory states.
Our results unveil strikingly different recruitment mechanisms of Sp1/Sp2/Sp3 transcription factor members uncovering an unexpected layer of complexity in their binding to chromatin in vivo.
age-dependent alteration in the Fmr-1 (show FMR1 Proteins) gene expression is associated with Sp1 interaction with Fmr-1 (show FMR1 Proteins) promoter which in turn might be related with cognitive development during brain maturation and aging.
The results of this study suggest that SP4 and SP1 upregulation may be part of the mechanisms deregulated downstream of glutamate (show GRIN1 Proteins) signalling pathways in schizophrenia
The transcription factor SP1 is induced in brain by ischemia/reperfusion.
Data suggest that retinoic acid and GM-CSF (show CSF2 Proteins)-induced retinal dehydrogenase 2 (RALDH2 (show ALDH1A2 Proteins)) expression in dendritic cells requires cooperative binding of transcription factor Sp1 via the RA receptor/retinoid X receptor (show RXRB Proteins) complex to the Aldh1a2 (show ALDH1A1 Proteins) promoter.
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
, transcription factor Sp1
, transcription factor
, Sp1 transcription factor
, transcription factor Sp1-like
, specificity protein 1
, specific protein-1
, trans-acting transcription factor 1