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Sp1 Transcription Factor Proteins (SP1)

The protein encoded by SP1 is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. Additionally we are shipping SP1 Antibodies (281) and SP1 Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SP1 6667 P08047
Rat SP1 SP1 24790 Q01714
SP1 20683 O89090
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Top SP1 Proteins at

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human His tag,S tag   100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human His tag,S tag 100 μg Log in to see 11 to 13 Days
HOST_Baculovirus Human His tag TransAM® standard curve generated using Recombinant Sp1 protein. The standard curve for TransAM® was generated using a range of 320-40 ng of protein and run on the TransAM® Sp1 ELISA Kit. 5 μg Log in to see 1 to 2 Days
HOST_HeLa Cells Human Un-conjugated   2 μg Log in to see 1 to 2 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 16 Days

SP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for Sp1 Transcription Factor (SP1) Interaction Partners

Zebrafish Sp1 Transcription Factor (SP1) interaction partners

  1. A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (show ATP7A Proteins), sp1 and sod1 (show SOD1 Proteins) in zebrafish.

  2. zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1

Human Sp1 Transcription Factor (SP1) interaction partners

  1. we verified that miR (show MLXIP Proteins)-892b regulates the p19ARF/cyclin D1 (show CCND1 Proteins)/CDK6 (show CDK6 Proteins) and Sp-1 (show PSG1 Proteins)/MMP-9 (show MMP9 Proteins) signaling networks in bladder cancer cells and may provide a treatment option for advanced-stage bladder cancers.

  2. Study provides evidence that Mef2c (show MEF2C Proteins) cooperated with Sp1 (show PSG1 Proteins) to activate human AQP1 (show AQP1 Proteins) transcription by binding to its proximal promoter in human umbilical cord vein endothelial cells indicating that AQP1 (show AQP1 Proteins) is a direct target of Mef2c (show MEF2C Proteins) in regulating angiogenesis and vasculogenesis of endothelial cells.

  3. MiR (show MLXIP Proteins)-375 inhibited the proliferation, invasion and migration by directly targeting SP1 (show PSG1 Proteins).

  4. High SP1 (show PSG1 Proteins) expression is associated with ovarian cancer.

  5. miR (show MLXIP Proteins)-326 can restore CDDP chemosensitivity in the human lung adenocarcinoma cells by targeting SP1 (show PSG1 Proteins), and HOTAIR upregulate the expression of miR (show MLXIP Proteins)-326 target gene SP1 (show PSG1 Proteins).

  6. TEAD1 (show TEAD1 Proteins) could enhance the expression levels of SP1 (show PSG1 Proteins), by directly binding to its promoter.

  7. site-directed mutagenesis of potential SP1 (show PSG1 Proteins) binding sites diminished both DNA-protein complexes and SP1 (show PSG1 Proteins)-mediated upregulation of URG-4 (show URGCP Proteins) promoter activity. These findings are valuable for understanding transcriptional regulation of URG4/URGCP (show URGCP Proteins) that has a pivotal role in cancer progression.

  8. Sp1 (show PSG1 Proteins) up-regulated TMEPAI (show PMEPA1 Proteins) protein expression, as well as Sp1 (show PSG1 Proteins) promoting TMEPAI (show PMEPA1 Proteins)-induced cell proliferation.

  9. the results of this study suggest that the miR (show MLXIP Proteins)-24/SP1 (show PSG1 Proteins) pathway contributed to the reduction in radioresistance in human NPC (show NPC1 Proteins) and that it may thus represent a therapeutic target.

  10. we predicted CG-rich region of miR (show MLXIP Proteins)-23a-27a-24-2 cluster (miR (show MLXIP Proteins)-23a, miR (show MLXIP Proteins)-27a, and miR (show MLXIP Proteins)-24-2)promoter and detected the methylation status in the region spanning two SP1 (show PSG1 Proteins) sites.

Cow (Bovine) Sp1 Transcription Factor (SP1) interaction partners

  1. study demonstrates the co-expression of DLX3 (show DLX3 Proteins), PPARG (show PPARG Proteins) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation

  2. likely involvement of the Sp family in regulating PTH (show PTH Proteins) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.

  3. These results demonstrate that the single nucleotide polymorphism alters the bovine FASN promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.

  4. The coordinate regulation of the bovine PRNP (show PRNP Proteins) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (show PRNP Proteins) promoter and its activity.

Mouse (Murine) Sp1 Transcription Factor (SP1) interaction partners

  1. miR (show MLXIP Proteins)-124, -128, and -137 act synergistically to regulate Sp1 expression.

  2. YY1 (show YY1 Proteins) and SP1 independently and cooperatively govern the Mesp1 (show MESP1 Proteins) expression during embryogenesis.

  3. Taken together, these results indicate that the transcription factor Sp1 upregulates the proximal promoter activity of the mouse Col11a1 gene in chondrocytes.

  4. In the initial stage of myocyte differentiation, transcription of the YB-1 (show YBX1 Proteins) gene was regulated by E2F1 (show E2F1 Proteins) and Sp1, and was then gradually replaced under the control of both MyoD (show MYOD1 Proteins) and myogenin (show MYOG Proteins).

  5. Data indicate that Sp1 and AP-1 (show JUN Proteins)-related factors are involved in the regulation of MFG-E8 (show MFGE8 Proteins) gene transcription by targeting their binding sites in the 5'-flanking region under physiological and inflammatory states.

  6. Our results unveil strikingly different recruitment mechanisms of Sp1/Sp2/Sp3 transcription factor members uncovering an unexpected layer of complexity in their binding to chromatin in vivo.

  7. age-dependent alteration in the Fmr-1 (show FMR1 Proteins) gene expression is associated with Sp1 interaction with Fmr-1 (show FMR1 Proteins) promoter which in turn might be related with cognitive development during brain maturation and aging.

  8. The results of this study suggest that SP4 and SP1 upregulation may be part of the mechanisms deregulated downstream of glutamate (show GRIN1 Proteins) signalling pathways in schizophrenia

  9. The transcription factor SP1 is induced in brain by ischemia/reperfusion.

  10. Data suggest that retinoic acid and GM-CSF (show CSF2 Proteins)-induced retinal dehydrogenase 2 (RALDH2 (show ALDH1A2 Proteins)) expression in dendritic cells requires cooperative binding of transcription factor Sp1 via the RA receptor/retinoid X receptor (show RXRB Proteins) complex to the Aldh1a2 (show ALDH1A1 Proteins) promoter.

SP1 Protein Profile

Protein Summary

The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Sp1 Transcription Factor Proteins (SP1)

  • sp1 transcription factor (sp1)
  • Sp1 transcription factor (sp1)
  • Sp1 transcription factor (SP1)
  • Sp1 transcription factor (LOC100351317)
  • Sp1 transcription factor (Sp1)
  • trans-acting transcription factor 1 (Sp1)
  • 1110003E12Rik protein
  • AA450830 protein
  • AI845540 protein
  • fc18h09 protein
  • SP1 protein
  • Sp1-1 protein
  • wu:fc18h09 protein
  • zgc:85950 protein

Protein level used designations for Sp1 Transcription Factor Proteins (SP1)

Sp1-like protein , transcription factor Sp1 , transcription factor , Sp1 transcription factor , transcription factor Sp1-like , specificity protein 1 , specific protein-1 , trans-acting transcription factor 1

324109 Danio rerio
394744 Xenopus (Silurana) tropicalis
451939 Pan troglodytes
702710 Macaca mulatta
100351317 Oryctolagus cuniculus
100407824 Callithrix jacchus
100440745 Pongo abelii
100474983 Ailuropoda melanoleuca
100553756 Anolis carolinensis
100585963 Nomascus leucogenys
6667 Homo sapiens
540741 Bos taurus
24790 Rattus norvegicus
397314 Sus scrofa
431939 Xenopus laevis
395303 Gallus gallus
486507 Canis lupus familiaris
100303456 Ovis aries
20683 Mus musculus
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