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The protein encoded by SP1 is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. Additionally we are shipping SP1 Antibodies (228) and SP1 Kits (25) and many more products for this protein.
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A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (show ATP7A Proteins), sp1 and sod1 (show SOD1 Proteins) in zebrafish.
zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
Ginsenoside Rg3 induces FUT4 (show FUT4 Proteins)-mediated apoptosis in H. pylori CagA (show S100A8 Proteins)-treated gastric cancer cells by regulating SP1 (show PSG1 Proteins) and HSF1 (show HSF1 Proteins) expressions
miR (show MLXIP Proteins)-23b/SP1 (show PSG1 Proteins)/c-myc (show MYC Proteins) forms a feed-forward loop supporting multiple myeloma cell growth
these data indicate that activation of EGFR (show EGFR Proteins) enhanced the expression of P2X7R (show P2RX7 Proteins) in neuroblastoma (show ARHGEF16 Proteins) cells lacking trophic support, being PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/PKC (show PRRT2 Proteins) signaling pathway and Sp1 (show PSG1 Proteins) mediating this pro-survival outcome
This is the first study indicating that Sp1 (show PSG1 Proteins) signaling plays an important role in the regulation of human LRRK2 (show LRRK2 Proteins) gene expression.
The cross-talk between SP1 (show PSG1 Proteins) and p65 (show GORASP1 Proteins), and the positive feedback regulatory loop of PI3-K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling by EP4 (show PTGER4 Proteins) contribute to the overall responses of solamargine in this process
These results suggest that STAT6 (show STAT6 Proteins) plays an important role in regulating Sp1 (show PSG1 Proteins) and BCL6 (show BCL6 Proteins) through STAT2 (show STAT2 Proteins) to exert the anti-proliferative effects of type I IFN.
Binding of Sp1 (show PSG1 Proteins) to the 5' splice site region had an inhibitory effect on L4-22K-activated major late promoter transcription.
TRIM22 (show TRIM22 Proteins) acts as a suppressor of basal HIV-1 LTR-driven transcription by preventing Sp1 (show PSG1 Proteins) binding to the HIV-1 promoter
Identify SP1 (show PSG1 Proteins) and PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling as modulators of EWS (show EWSR1 Proteins)/FLI1 (show FLI1 Proteins) gene expression in tumor cell lines.
AHR (show AHR Proteins) promoter variant modulates its transcription and downstream effectors by allele-specific AHR (show AHR Proteins)-SP1 (show PSG1 Proteins) interaction functioning as a genetic marker for vitiligo (show MITF Proteins)
study demonstrates the co-expression of DLX3 (show DLX3 Proteins), PPARG (show PPARG Proteins) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
likely involvement of the Sp family in regulating PTH (show PTH Proteins) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.
The coordinate regulation of the bovine PRNP (show PRNP Proteins) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (show PRNP Proteins) promoter and its activity.
Data indicate that higher hepatic glucocorticoid receptor (GR (show NR3C1 Proteins)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 (show TP53 Proteins) and specificity protein 1 (Sp1).
transcription factor Sp1 interacts with nucleotides -123/-114, indicating that Sp1 could play a key role in the transcriptional regulation of pig CAV-1 (show CAV1 Proteins)
Viral non-structural protein 1 suppressed host TNF-alpha (show TNF Proteins) promoter by inhibiting NF-kappaB (show NFKB1 Proteins) and Sp1 promoter binding activity.
Basal transcription and supra-additive stimulation of porcine LDLR gene transcription by LH and insulin in granulosa-luteal cells require SREBP-1a and Sp1/Sp3-binding elements.
LH and insulin (show INS Proteins) stimulate transcription of -976/+31 bp 5 (show HSPD1 Proteins)'-upstream cis (show CISH Proteins)-acting region of porcine CYP17 (show CYP17A1 Proteins) gene. Maximal transcriptional responsiveness requires proximal Sp1 and AP-2-like (show TFAP2D Proteins) sequences -193 to -180 bp 5 (show HSPD1 Proteins)' upstream of transcriptional start site.
KLF13 (show KLF13 Proteins) and SREBP-Sp1 activation interact to regulate low density lipoprotein receptor (show LDLR Proteins) promoter function
SP1 and SMAD3 (show SMAD3 Proteins) are required for high glucose-induced p21(WAF1 (show CDKN1A Proteins)) gene transcription in LLC-PK1 (show PKLR Proteins) cells.
In the initial stage of myocyte differentiation, transcription of the YB-1 (show YBX1 Proteins) gene was regulated by E2F1 (show E2F1 Proteins) and Sp1, and was then gradually replaced under the control of both MyoD (show MYOD1 Proteins) and myogenin (show MYOG Proteins).
Data indicate that Sp1 and AP-1 (show JUN Proteins)-related factors are involved in the regulation of MFG-E8 (show MFGE8 Proteins) gene transcription by targeting their binding sites in the 5'-flanking region under physiological and inflammatory states.
Our results unveil strikingly different recruitment mechanisms of Sp1/Sp2/Sp3 transcription factor members uncovering an unexpected layer of complexity in their binding to chromatin in vivo.
age-dependent alteration in the Fmr-1 (show FMR1 Proteins) gene expression is associated with Sp1 interaction with Fmr-1 (show FMR1 Proteins) promoter which in turn might be related with cognitive development during brain maturation and aging.
The results of this study suggest that SP4 and SP1 upregulation may be part of the mechanisms deregulated downstream of glutamate (show GRIN1 Proteins) signalling pathways in schizophrenia
The transcription factor SP1 is induced in brain by ischemia/reperfusion.
Data suggest that retinoic acid and GM-CSF (show CSF2 Proteins)-induced retinal dehydrogenase 2 (RALDH2 (show ALDH1A2 Proteins)) expression in dendritic cells requires cooperative binding of transcription factor Sp1 via the RA receptor/retinoid X receptor (show RXRB Proteins) complex to the Aldh1a2 (show ALDH1A1 Proteins) promoter.
Sp1/Sp3 transcription factors have roles in regulating hallmarks of megakaryocyte maturation and platelet formation and function
Our findings suggest that an SOHLH2 (show SOHLH2 Proteins)/SOHLH1 (show SOHLH1 Proteins)/SP1 ternary complex autonomously and cooperatively regulates Sohlh1 (show SOHLH1 Proteins) gene transcription through juxtaposed E- and GC-boxes during early spermatogenesis and oogenesis.
Results identify Sp1 as an inhibitor of DsbA-L (show GSTK1 Proteins) gene transcription, and the Sp1-mediated inhibition of DsbA-L (show GSTK1 Proteins) gene expression may provide a mechanism underlying obesity-induced adiponectin (show ADIPOQ Proteins) downregulation and insulin (show INS Proteins) resistance.
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
, transcription factor Sp1
, transcription factor
, Sp1 transcription factor
, transcription factor Sp1-like
, specificity protein 1
, specific protein-1
, trans-acting transcription factor 1