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Sp1 Transcription Factor Proteins (SP1)

The protein encoded by SP1 is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. Additionally we are shipping SP1 Antibodies (237) and SP1 Kits (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SP1 6667 P08047
Rat SP1 SP1 24790 Q01714
SP1 20683 O89090
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Top SP1 Proteins at

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human His tag,S tag   100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human His tag,S tag 100 μg Log in to see 11 to 13 Days
HOST_Baculovirus Human His tag TransAM® standard curve generated using Recombinant Sp1 protein. The standard curve for TransAM® was generated using a range of 320-40 ng of protein and run on the TransAM® Sp1 ELISA Kit. 5 μg Log in to see 1 to 2 Days
HOST_HeLa Cells Human Un-conjugated   2 μg Log in to see 1 to 2 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 16 Days

SP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for Sp1 Transcription Factor (SP1) Interaction Partners

Zebrafish Sp1 Transcription Factor (SP1) interaction partners

  1. A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (show ATP7A Proteins), sp1 and sod1 (show SOD1 Proteins) in zebrafish.

  2. zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1

Human Sp1 Transcription Factor (SP1) interaction partners

  1. Ginsenoside Rg3 induces FUT4 (show FUT4 Proteins)-mediated apoptosis in H. pylori CagA (show S100A8 Proteins)-treated gastric cancer cells by regulating SP1 (show PSG1 Proteins) and HSF1 (show HSF1 Proteins) expressions

  2. miR (show MLXIP Proteins)-23b/SP1 (show PSG1 Proteins)/c-myc (show MYC Proteins) forms a feed-forward loop supporting multiple myeloma cell growth

  3. these data indicate that activation of EGFR (show EGFR Proteins) enhanced the expression of P2X7R (show P2RX7 Proteins) in neuroblastoma (show ARHGEF16 Proteins) cells lacking trophic support, being PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/PKC (show PRRT2 Proteins) signaling pathway and Sp1 (show PSG1 Proteins) mediating this pro-survival outcome

  4. This is the first study indicating that Sp1 (show PSG1 Proteins) signaling plays an important role in the regulation of human LRRK2 (show LRRK2 Proteins) gene expression.

  5. The cross-talk between SP1 (show PSG1 Proteins) and p65 (show GORASP1 Proteins), and the positive feedback regulatory loop of PI3-K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling by EP4 (show PTGER4 Proteins) contribute to the overall responses of solamargine in this process

  6. These results suggest that STAT6 (show STAT6 Proteins) plays an important role in regulating Sp1 (show PSG1 Proteins) and BCL6 (show BCL6 Proteins) through STAT2 (show STAT2 Proteins) to exert the anti-proliferative effects of type I IFN.

  7. Binding of Sp1 (show PSG1 Proteins) to the 5' splice site region had an inhibitory effect on L4-22K-activated major late promoter transcription.

  8. TRIM22 (show TRIM22 Proteins) acts as a suppressor of basal HIV-1 LTR-driven transcription by preventing Sp1 (show PSG1 Proteins) binding to the HIV-1 promoter

  9. Identify SP1 (show PSG1 Proteins) and PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling as modulators of EWS (show EWSR1 Proteins)/FLI1 (show FLI1 Proteins) gene expression in tumor cell lines.

  10. AHR (show AHR Proteins) promoter variant modulates its transcription and downstream effectors by allele-specific AHR (show AHR Proteins)-SP1 (show PSG1 Proteins) interaction functioning as a genetic marker for vitiligo (show MITF Proteins)

Cow (Bovine) Sp1 Transcription Factor (SP1) interaction partners

  1. study demonstrates the co-expression of DLX3 (show DLX3 Proteins), PPARG (show PPARG Proteins) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation

  2. likely involvement of the Sp family in regulating PTH (show PTH Proteins) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.

  3. These results demonstrate that the single nucleotide polymorphism alters the bovine FASN promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.

  4. The coordinate regulation of the bovine PRNP (show PRNP Proteins) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (show PRNP Proteins) promoter and its activity.

Pig (Porcine) Sp1 Transcription Factor (SP1) interaction partners

  1. Data indicate that higher hepatic glucocorticoid receptor (GR (show NR3C1 Proteins)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 (show TP53 Proteins) and specificity protein 1 (Sp1).

  2. transcription factor Sp1 interacts with nucleotides -123/-114, indicating that Sp1 could play a key role in the transcriptional regulation of pig CAV-1 (show CAV1 Proteins)

  3. Viral non-structural protein 1 suppressed host TNF-alpha (show TNF Proteins) promoter by inhibiting NF-kappaB (show NFKB1 Proteins) and Sp1 promoter binding activity.

  4. Basal transcription and supra-additive stimulation of porcine LDLR gene transcription by LH and insulin in granulosa-luteal cells require SREBP-1a and Sp1/Sp3-binding elements.

  5. LH and insulin (show INS Proteins) stimulate transcription of -976/+31 bp 5 (show HSPD1 Proteins)'-upstream cis (show CISH Proteins)-acting region of porcine CYP17 (show CYP17A1 Proteins) gene. Maximal transcriptional responsiveness requires proximal Sp1 and AP-2-like (show TFAP2D Proteins) sequences -193 to -180 bp 5 (show HSPD1 Proteins)' upstream of transcriptional start site.

  6. KLF13 (show KLF13 Proteins) and SREBP-Sp1 activation interact to regulate low density lipoprotein receptor (show LDLR Proteins) promoter function

  7. SP1 and SMAD3 (show SMAD3 Proteins) are required for high glucose-induced p21(WAF1 (show CDKN1A Proteins)) gene transcription in LLC-PK1 (show PKLR Proteins) cells.

Mouse (Murine) Sp1 Transcription Factor (SP1) interaction partners

  1. In the initial stage of myocyte differentiation, transcription of the YB-1 (show YBX1 Proteins) gene was regulated by E2F1 (show E2F1 Proteins) and Sp1, and was then gradually replaced under the control of both MyoD (show MYOD1 Proteins) and myogenin (show MYOG Proteins).

  2. Data indicate that Sp1 and AP-1 (show JUN Proteins)-related factors are involved in the regulation of MFG-E8 (show MFGE8 Proteins) gene transcription by targeting their binding sites in the 5'-flanking region under physiological and inflammatory states.

  3. Our results unveil strikingly different recruitment mechanisms of Sp1/Sp2/Sp3 transcription factor members uncovering an unexpected layer of complexity in their binding to chromatin in vivo.

  4. age-dependent alteration in the Fmr-1 (show FMR1 Proteins) gene expression is associated with Sp1 interaction with Fmr-1 (show FMR1 Proteins) promoter which in turn might be related with cognitive development during brain maturation and aging.

  5. The results of this study suggest that SP4 and SP1 upregulation may be part of the mechanisms deregulated downstream of glutamate (show GRIN1 Proteins) signalling pathways in schizophrenia

  6. The transcription factor SP1 is induced in brain by ischemia/reperfusion.

  7. Data suggest that retinoic acid and GM-CSF (show CSF2 Proteins)-induced retinal dehydrogenase 2 (RALDH2 (show ALDH1A2 Proteins)) expression in dendritic cells requires cooperative binding of transcription factor Sp1 via the RA receptor/retinoid X receptor (show RXRB Proteins) complex to the Aldh1a2 (show ALDH1A1 Proteins) promoter.

  8. Sp1/Sp3 transcription factors have roles in regulating hallmarks of megakaryocyte maturation and platelet formation and function

  9. Our findings suggest that an SOHLH2 (show SOHLH2 Proteins)/SOHLH1 (show SOHLH1 Proteins)/SP1 ternary complex autonomously and cooperatively regulates Sohlh1 (show SOHLH1 Proteins) gene transcription through juxtaposed E- and GC-boxes during early spermatogenesis and oogenesis.

  10. Results identify Sp1 as an inhibitor of DsbA-L (show GSTK1 Proteins) gene transcription, and the Sp1-mediated inhibition of DsbA-L (show GSTK1 Proteins) gene expression may provide a mechanism underlying obesity-induced adiponectin (show ADIPOQ Proteins) downregulation and insulin (show INS Proteins) resistance.

SP1 Protein Profile

Protein Summary

The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Sp1 Transcription Factor Proteins (SP1)

  • sp1 transcription factor (sp1)
  • Sp1 transcription factor (sp1)
  • Sp1 transcription factor (SP1)
  • Sp1 transcription factor (LOC100351317)
  • Sp1 transcription factor (Sp1)
  • trans-acting transcription factor 1 (Sp1)
  • 1110003E12Rik protein
  • AA450830 protein
  • AI845540 protein
  • fc18h09 protein
  • SP1 protein
  • Sp1-1 protein
  • wu:fc18h09 protein
  • zgc:85950 protein

Protein level used designations for Sp1 Transcription Factor Proteins (SP1)

Sp1-like protein , transcription factor Sp1 , transcription factor , Sp1 transcription factor , transcription factor Sp1-like , specificity protein 1 , specific protein-1 , trans-acting transcription factor 1

324109 Danio rerio
394744 Xenopus (Silurana) tropicalis
451939 Pan troglodytes
702710 Macaca mulatta
100351317 Oryctolagus cuniculus
100407824 Callithrix jacchus
100440745 Pongo abelii
100474983 Ailuropoda melanoleuca
100553756 Anolis carolinensis
100585963 Nomascus leucogenys
6667 Homo sapiens
540741 Bos taurus
24790 Rattus norvegicus
397314 Sus scrofa
431939 Xenopus laevis
395303 Gallus gallus
486507 Canis lupus familiaris
100303456 Ovis aries
20683 Mus musculus
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