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SP1 Products

(Sp1 Transcription Factor (SP1))
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

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Featured SP1 Categories

SP1 Antibodies

High quality antibodies with extensive validation data.

SP1 ELISA Kits

Reliable ELISA kits for a wide range of species.

SP1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SP1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ICC, IF, IHC (p), WB
Validations
  • (6)
Cat. No. ABIN2855540
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, ICC, IF, IHC, WB
Validations
  • (12)
Cat. No. ABIN6256566
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application FACS, IF, IHC, ELISA, WB
Validations
  • (7)
Cat. No. ABIN3032701
Quantity 0.4 mL
Datasheet Datasheet

Recommended SP1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Semi-Quantitative DNA-Binding ELISA
Validations
  • (2)
Cat. No. ABIN5690763
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970379
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970380
Quantity 96 tests
Datasheet Datasheet

Recommended SP1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3095640
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3132312
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1321017
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our SP1 products

Zhang, Liu, Su, Bai, Zhao, Zhao: "Resistin impairs activation of protein C by suppressing EPCR and increasing SP1 expression." in: Biomedicine & pharmacotherapy, Vol. 109, pp. 930-937, (2019) (PubMed).

Yang, Li, Wang, Hou, Qiu, Wang, Wu: "Long-term persistent infection of HPV 16 E6 up-regulate SP1 and hTERT by inhibiting LKB1 in lung cancer cells." in: PLoS ONE, Vol. 12, Issue 8, pp. e0182775, (2017) (PubMed).

Zhang, Liu, Liu, Zhou, Song, Cao, An: "miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression." in: PLoS ONE, Vol. 12, Issue 7, pp. e0179783, (2017) (PubMed).

Yang, Cui, Xue, Overstreet, Zhan, Shan, Li, Li, Wang, Zhang, Yu, Xu: "Resveratrol Represses Pokemon Expression in Human Glioma Cells." in: Molecular neurobiology, Vol. 53, Issue 2, pp. 1266-78, (2016) (PubMed).

Lee, Park, Byun, Kim, Ryu, Lee, Kim: "Silencing of voltage-gated potassium channel KV9.3 inhibits proliferation in human colon and lung carcinoma cells." in: Oncotarget, Vol. 6, Issue 10, pp. 8132-43, (2015) (PubMed).

Chen, Tang, Wu, Zheng, Yang, Hann: "Inactivation of PI3-K/Akt and reduction of SP1 and p65 expression increase the effect of solamargine on suppressing EP4 expression in human lung cancer cells." in: Journal of experimental & clinical cancer research : CR, Vol. 34, pp. 154, (2015) (PubMed).

Sakamoto, Akiyama, Shimada, Zhu, Yuasa, Tanaka: "DNA Methylation in the Exon 1 Region and Complex Regulation of Twist1 Expression in Gastric Cancer Cells." in: PLoS ONE, Vol. 10, Issue 12, pp. e0145630, (2015) (PubMed).

Lee, Ryu, Lee: "Serum starvation-induced voltage-gated potassium channel Kv7.5 expression and its regulation by Sp1 in canine osteosarcoma cells." in: International journal of molecular sciences, Vol. 15, Issue 1, pp. 977-93, (2014) (PubMed).

Qi, Zhang, Li, Frank, Dai, Liu, Chen: "MicroRNA-29b regulates ethanol-induced neuronal apoptosis in the developing cerebellum through SP1/RAX/PKR cascade." in: The Journal of biological chemistry, Vol. 289, Issue 14, pp. 10201-10, (2014) (PubMed).

Zhang, Wang, Qin, Liu, Sun, Liu, Kuang, Jiang, Zhang: "cis-Acting elements and trans-acting factors in the transcriptional regulation of raf kinase inhibitory protein expression." in: PLoS ONE, Vol. 8, Issue 12, pp. e83097, (2014) (PubMed).

Synonyms and alternative names related to SP1

sp1 transcription factor (sp1), Sp1 transcription factor (sp1), Sp1 transcription factor (SP1), Sp1 transcription factor (Sp1), Sp1 transcription factor L homeolog (sp1.L), trans-acting transcription factor 1 (Sp1), 1110003E12Rik, AA450830, AI845540, fc18h09, SP1, Sp1-1, wu:fc18h09, zgc:85950

Protein level used designations for SP1

  • Sp1-like protein
  • transcription factor Sp1
  • transcription factor
  • Sp1 transcription factor
  • transcription factor Sp1-like
  • specificity protein 1
  • specific protein-1
  • trans-acting transcription factor 1
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