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SPAG5 encodes a protein associated with the mitotic spindle apparatus. Additionally we are shipping SPAG5 Antibodies (30) and many more products for this protein.
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Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP (show KNSTRN Proteins) and Astrin have been reported.
SPAG5 upregulation relates to poor prognosis in cervical cancer patients, and SPAG5 is a regulator of mTOR (show FRAP1 Proteins) activity during taxol treatment in cervical cancer.
Astrin acts as a mitotic phosphoprotein during the regulation of mitosis.
Study identifies astrin as an essential negative mTORC1 regulator in the cellular stress response. Upon stress, astrin inhibits mTORC1 association and recruits the mTORC1 component raptor (show RPTOR Proteins) to stress granules, thereby preventing mTORC1-hyperactivation-induced apoptosis.
Data show that CLASP1 (show CLASP1 Proteins)-astrin-Kif2b (show KIF2B Proteins) complex acts as a central switch at kinetochores that defines mitotic progression and promotes fidelity by temporally regulating kinetochore-microtuble attachments.
These findings suggest that the silencing of astrin induce a p53 (show TP53 Proteins)-dependent apoptosis and has an additive effect on paclitaxel treatment.
a model is proposed wherein hNinein regulates the dynamic movement of Astrin throughout the cell cycle and this interaction, in turn, is required for maintenance of centrosome/spindle pole integrity.
Results report that depletion of the microtubule and kinetochore protein astrin results in checkpoint-arrested cells with multipolar spindles and separated sister chromatids, which is consistent with untimely separase activation.
GSK3beta interacts with and phosphorylates the spindle-associated (show HAUS1 Proteins) protein Astrin, resulting in targeting Astrin to the spindle microtubules and kinetochores.
Astrin acts upstream of Aurora-A (show AURKA Proteins) to regulate its mitotic spindle localization.
cloning and genomic structure of mastrin; mastrin protein was demonstrated to localize to mitotic spindles during mitosis[masatrin]
Loss-of-function of Astrin by RNAi and overexpression of the coiled-coil domain results in spindle disorganization, chromosome misalignment and meiosis progression arrest.
This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles.
sperm associated antigen 5
, sperm-associated antigen 5-like
, mitotic spindle associated protein p126
, mitotic spindle coiled-coil related protein
, mitotic spindle-associated protein p126
, sperm-associated antigen 5
, microtubule-associated protein