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Sphingosine Kinase 1 (SPHK1) ELISA Kits

The protein encoded by SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Additionally we are shipping Sphingosine Kinase 1 Antibodies (199) and Sphingosine Kinase 1 Proteins (13) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SPHK1 8877 Q9NYA1
SPHK1 20698 Q8CI15
SPHK1 170897 Q91V26
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Top Sphingosine Kinase 1 ELISA Kits at antibodies-online.com

Showing 3 out of 8 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.122 ng/mL 0.31-20 ng/mL 96 Tests Log in to see 9 to 11 Days
$736.84
Details
Mouse 31.2-2000 pg/mL   96 Tests Log in to see 11 to 13 Days
$875.60
Details
Rat
  96 Tests Log in to see 11 to 13 Days
$875.60
Details

More ELISA Kits for Sphingosine Kinase 1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Sphingosine Kinase 1 (SPHK1) interaction partners

  1. Sk1 and Sk2 (show KCNN2 ELISA Kits) are not redundant in biological function and are essential for diverse physiological functions in Drosophila

Arabidopsis thaliana Sphingosine Kinase 1 (SPHK1) interaction partners

  1. SPHK/phyto-S1P (show MBTPS1 ELISA Kits) and PLDalpha1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis.

  2. Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase.

Human Sphingosine Kinase 1 (SPHK1) interaction partners

  1. demonstrated the roles played by miR (show MLXIP ELISA Kits)-144-3p and FN1 (show FN1 ELISA Kits) in mediating the oncogenic function of SphK1, which enhanced the understanding of the etiology of PTC (show F9 ELISA Kits)

  2. SphK1 is associated with the proliferation and invasiveness of CRC (show CALR ELISA Kits) cells and the SphK1 gene may contribute to a novel therapeutic approach against CRC (show CALR ELISA Kits).

  3. The levels of SphK1 were significantly increased in triple-negative breast cancer patients compared with normal controls. SphK1 knockdown with siRNA decreased TNBC cell proliferation and inhibited cell migration/invasion, suggesting that SphK1 has an important role in TNBC.

  4. SPHK1 mRNA is up-regulation in colorectal cancer.

  5. Found that upregulation of SphK1 expression in the stiff substrate is dominant in metastatic cancer cells but not in primary cancer cells. These results suggest that alterations in the mechanical environment of the extracellular matrix surrounding the tumor cells actively regulate cellular properties such as secretion, which in turn, may contribute to cancer progression.

  6. In conclusion, these data suggested that HuR (show ELAVL1 ELISA Kits) bound to SphK1 mRNA and played a crucial role in TGF-beta1 (show TGFB1 ELISA Kits)-induced hepatic stellate cell activation.

  7. low oxLDL concentration triggers sprouting angiogenesis that involves ROS (show ROS1 ELISA Kits)-induced activation of the neutral sphingomyelinase-2/sphingosine kinase-1 pathway, and is effectively inhibited by GW4869.

  8. SphK1 expression is functionally associated to cellular proliferation, apoptosis, invasion and mitotane sensitivity of adrenocortical carcinoma.

  9. Data show that long non-coding RNA HULC promotes tumor angiogenesis in liver cancer through microRNA miR (show MLXIP ELISA Kits)-107/E2F1 transcription factor (E2F1 (show E2F1 ELISA Kits))/sphingosine kinase 1 (SPHK1) signaling.

  10. High SPHK1 expression is associated with ovarian cancer.

Mouse (Murine) Sphingosine Kinase 1 (SPHK1) interaction partners

  1. These findings suggest that the inhibitory effect of these plant extracts on the activation of AGEs/RAGE (show AGER ELISA Kits)/SphK1 signaling pathway in db/db (show LEPR ELISA Kits) diabetic mice kidney is a novel mechanism by which they exert renoprotective effects in diabetic nephropathy.

  2. Keratinocyte-specific deletion of Traf2 (show TRAF2 ELISA Kits), but not Sphk1 deficiency, disrupted TNF (show TNF ELISA Kits) mediated NF-kappaB (show NFKB1 ELISA Kits) and MAP kinase (show MAPK1 ELISA Kits) signalling and caused epidermal hyperplasia and psoriatic skin inflammation.

  3. SphK1 dependent PKC-delta (show PKCd ELISA Kits) activation plays an important role in promoting NF-kappaB (show NFKB1 ELISA Kits) activation and inflammatory response in acute liver failure, and inhibition of PKC-delta (show PKCd ELISA Kits) activation might be a potential therapeutic strategy for this disease.

  4. Inhibition of SphK1 ameliorates drug-induced acute liver failure by reducing HMGB1 (show HMGB1 ELISA Kits) cytoplasmic translocation in liver cells.

  5. Collectively, our results demonstrate that PF-543 exerts potent anti-CRC (show SCRIB ELISA Kits) activity in vitro and in vivo.

  6. transient receptor potential channel 1 suppression of basal sphingosine kinase 1 activity enables endothelial cell-barrier destabilization by edemagenic agonists

  7. Based on these findings, the authors propose new roles for SK1 in affecting innate responses that regulate susceptibility to dengue virus infection.

  8. Together, these results suggest that alpha-MSH alleviates Dex-induced damages to cultured osteoblasts through activating MC4R (show MC4R ELISA Kits)-SphK1 signaling.

  9. The study demonstrates a new pathway connecting SphK1 and PPARgamma (show PPARG ELISA Kits) involved in the pathogenesis of hepatocellular steatosis.

  10. Inhibition of SK1 attenuates the second phase of transmembrane Calcium influx.

Sphingosine Kinase 1 (SPHK1) Antigen Profile

Antigen Summary

The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Sphingosine Kinase 1 (SPHK1) ELISA Kits

  • Sphingosine kinase 1 (Sk1) antibody
  • sphingosine kinase 1 (SPHK1) antibody
  • sphingosine kinase 1 (sphk1) antibody
  • sphingosine kinase 1 (LOC100357790) antibody
  • sphingosine kinase 1 (Sphk1) antibody
  • 1110006G24Rik antibody
  • CG1747 antibody
  • Dmel\\CG1747 antibody
  • F18E5.160 antibody
  • F18E5_160 antibody
  • Sk1 antibody
  • sphingosine kinase 1 antibody
  • SPHK antibody
  • SPHK1 antibody
  • Spk1 antibody

Protein level used designations for Sphingosine Kinase 1 (SPHK1) ELISA Kits

CG1747-PA , CG1747-PB , Sk1-PA , Sk1-PB , sphingosine kinase 1 , sphingosine kinase I , SK 1 , SPK 1

GENE ID SPECIES
32089 Drosophila melanogaster
427803 Gallus gallus
495437 Xenopus laevis
738821 Pan troglodytes
828239 Arabidopsis thaliana
100058875 Equus caballus
100357790 Oryctolagus cuniculus
8877 Homo sapiens
20698 Mus musculus
618605 Bos taurus
170897 Rattus norvegicus
483329 Canis lupus familiaris
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