Sphingosine Kinase 1 (SPHK1) ELISA Kits

The protein encoded by SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Additionally we are shipping Sphingosine Kinase 1 Antibodies (204) and Sphingosine Kinase 1 Proteins (15) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SPHK1 8877 Q9NYA1
SPHK1 20698 Q8CI15
SPHK1 170897 Q91V26
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Top Sphingosine Kinase 1 ELISA Kits at antibodies-online.com

Showing 3 out of 10 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.114 ng/mL 0.312-20 ng/mL 96 Tests Log in to see 15 to 17 Days
$908.41
Details
Mouse 31.2-2000 pg/mL   96 Tests Log in to see 15 to 18 Days
$875.60
Details
Rat
  96 Tests Log in to see 15 to 18 Days
$875.60
Details

More ELISA Kits for Sphingosine Kinase 1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Sphingosine Kinase 1 (SPHK1) interaction partners

  1. Sk1 and Sk2 (show KCNN2 ELISA Kits) are not redundant in biological function and are essential for diverse physiological functions in Drosophila

Arabidopsis thaliana Sphingosine Kinase 1 (SPHK1) interaction partners

  1. SPHK/phyto-S1P (show MBTPS1 ELISA Kits) and PLDalpha1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis.

  2. Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase.

Rabbit Sphingosine Kinase 1 (SPHK1) interaction partners

  1. Melatonin administration significantly inhibited those changes and induced a decreased immunoreactivity for rabbit hemorrhagic disease virus VP60 antigen in the liver. Results obtained indicate that the SphK1/S1P (show MBTPS1 ELISA Kits) system activates in parallel to viral replication and the inflammatory process induced by the virus.

Human Sphingosine Kinase 1 (SPHK1) interaction partners

  1. we identified sphingosine kinase 1 (SPHK1) as a novel target of miR (show MLXIP ELISA Kits)-506, the expression of which inhibited the SPHK1/Akt (show AKT1 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits) signaling pathway, which is activated in pancreatic cancer. High SPHK1 expression was significantly associated with poor survival in a large cohort of pancreatic cancer specimens.

  2. Inhibition of SPHK1 in human acute myeloid leukemia (show BCL11A ELISA Kits) cells induces MCL1 (show MCL1 ELISA Kits) degradation and caspase (show CASP3 ELISA Kits)-dependent cell death.

  3. The analysis suggests that the catalytic function and regulation of SPHK1 and SPHK2 (show SPHK2 ELISA Kits) might be dependent on their conformational mobility. (Review)

  4. our data suggest that SphK1 modulates the expression of EMT (show ITK ELISA Kits)-related markers and cell migration by regulating the expression of p-FAK (show PTK2 ELISA Kits) in CRC (show CALR ELISA Kits) cells. Thus, SphK1 may play a functional role in mediating the EMT (show ITK ELISA Kits) process in CRC (show CALR ELISA Kits).

  5. These results highlight the importance of sphingosine and its conversion to sphingosine-1-phosphate by SphK1 in endocytic membrane trafficking.

  6. By simulating therapeutic strategies that target multiple nodes of the pathway such as Raf and SphK1, we conclude that combination therapy should be much more effective in blocking VEGF signaling to EKR1/2. The model has important implications for interventions that target signaling pathways in angiogenesis relevant to cancer, vascular diseases, and wound healing.

  7. SphK1 is regulated by PDGF (show PDGFA ELISA Kits)-BB in pulmonary artery smooth muscle cells via the transcription factor Egr-1 (show EGR1 ELISA Kits), promoting cell proliferation.

  8. Melatonin-treated cells also exhibited an inhibition of the SphK1/S1P (show MBTPS1 ELISA Kits) axis. Antifibrogenic effect of SphK1 inhibition was confirmed by treatment of LX2 cells with PF543. Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.

  9. demonstrated the roles played by miR (show MLXIP ELISA Kits)-144-3p and FN1 (show FN1 ELISA Kits) in mediating the oncogenic function of SphK1, which enhanced the understanding of the etiology of PTC (show F9 ELISA Kits)

  10. SphK1 is associated with the proliferation and invasiveness of CRC (show CALR ELISA Kits) cells and the SphK1 gene may contribute to a novel therapeutic approach against CRC (show CALR ELISA Kits).

Mouse (Murine) Sphingosine Kinase 1 (SPHK1) interaction partners

  1. donor islets from mice deficient in Sphk1 KO contain a reduced number of resident intraislet vascular endothelial cells. The main product of Sphk1, sphingosine-1-phosphate, controls the migration of intraislet endothelial cells in vitro. In vivo, Sphk1 knockout islets have an impaired ability to cure diabetes compared with wild-type controls.

  2. Sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis by stimulation of proliferation of cancer cells.

  3. These results highlight the importance of sphingosine and its conversion to sphingosine-1-phosphate by SphK1 in endocytic membrane trafficking.

  4. Melatonin-treated cells also exhibited an inhibition of the SphK1/S1P (show S1PR1 ELISA Kits) axis. Antifibrogenic effect of SphK1 inhibition was confirmed by treatment of LX2 cells with PF543. Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.

  5. These findings suggest that the inhibitory effect of these plant extracts on the activation of AGEs/RAGE (show AGER ELISA Kits)/SphK1 signaling pathway in db/db (show LEPR ELISA Kits) diabetic mice kidney is a novel mechanism by which they exert renoprotective effects in diabetic nephropathy.

  6. Keratinocyte-specific deletion of Traf2 (show TRAF2 ELISA Kits), but not Sphk1 deficiency, disrupted TNF (show TNF ELISA Kits) mediated NF-kappaB (show NFKB1 ELISA Kits) and MAP kinase (show MAPK1 ELISA Kits) signalling and caused epidermal hyperplasia and psoriatic skin inflammation.

  7. SphK1 dependent PKC-delta (show PKCd ELISA Kits) activation plays an important role in promoting NF-kappaB (show NFKB1 ELISA Kits) activation and inflammatory response in acute liver failure, and inhibition of PKC-delta (show PKCd ELISA Kits) activation might be a potential therapeutic strategy for this disease.

  8. Inhibition of SphK1 ameliorates drug-induced acute liver failure by reducing HMGB1 (show HMGB1 ELISA Kits) cytoplasmic translocation in liver cells.

  9. Collectively, our results demonstrate that PF-543 exerts potent anti-CRC (show SCRIB ELISA Kits) activity in vitro and in vivo.

  10. transient receptor potential channel 1 suppression of basal sphingosine kinase 1 activity enables endothelial cell-barrier destabilization by edemagenic agonists

Sphingosine Kinase 1 (SPHK1) Antigen Profile

Antigen Summary

The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Sphingosine Kinase 1 (SPHK1) ELISA Kits

  • Sphingosine kinase 1 (Sk1) antibody
  • sphingosine kinase 1 (SPHK1) antibody
  • sphingosine kinase 1 (sphk1) antibody
  • sphingosine kinase 1 (LOC100357790) antibody
  • sphingosine kinase 1 (Sphk1) antibody
  • 1110006G24Rik antibody
  • CG1747 antibody
  • Dmel\\CG1747 antibody
  • F18E5.160 antibody
  • F18E5_160 antibody
  • Sk1 antibody
  • sphingosine kinase 1 antibody
  • SPHK antibody
  • SPHK1 antibody
  • Spk1 antibody

Protein level used designations for Sphingosine Kinase 1 (SPHK1) ELISA Kits

CG1747-PA , CG1747-PB , Sk1-PA , Sk1-PB , sphingosine kinase 1 , sphingosine kinase I , SK 1 , SPK 1

GENE ID SPECIES
32089 Drosophila melanogaster
427803 Gallus gallus
495437 Xenopus laevis
738821 Pan troglodytes
828239 Arabidopsis thaliana
100058875 Equus caballus
100357790 Oryctolagus cuniculus
8877 Homo sapiens
20698 Mus musculus
618605 Bos taurus
170897 Rattus norvegicus
483329 Canis lupus familiaris
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