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Synaptotagmin I Proteins (SYT1)

The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Additionally we are shipping SYT1 Antibodies (221) and SYT1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SYT1 74498 Q91X51
SYT1 6857 P21579
SYT1 25716 P21707
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Top SYT1 Proteins at

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 7 to 8 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
Yeast Aplysia californica His tag   1 mg Log in to see 56 to 66 Days
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days

SYT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
Human , , ,
, ,
Rat (Rattus)

Top referenced SYT1 Proteins

  1. Human SYT1 Protein expressed in Escherichia coli (E. coli) - ABIN667472 : Xi, Chin, Gainer: Analysis of synaptotagmin I-IV messenger RNA expression and developmental regulation in the rat hypothalamus and pituitary. in Neuroscience 1999 (PubMed)
    Show all 2 references for ABIN667472

  2. Human SYT1 Protein expressed in Wheat germ - ABIN1322010 : Liu, Akle, Zheng, Dave, Tortella, Hayes, Wang: Comparing calpain- and caspase-3-mediated degradation patterns in traumatic brain injury by differential proteome analysis. in The Biochemical journal 2006 (PubMed)

More Proteins for Synaptotagmin I (SYT1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Synaptotagmin I (SYT1) interaction partners

  1. tethering of Syt1 to synaptic vesicles in vivo is a prerequisite for its role in facilitating fast synchronous synaptic vesicle release and suppressing asynchronous and spontaneous fusion

  2. synaptic transmission can be regulated by Syt1 multimerization and that both C2 domains of Syt1 are uniquely required for modulating Ca(2 (show CA2 Proteins)+)-independent spontaneous fusion and Ca(2 (show CA2 Proteins)+)-dependent synchronous release.

  3. effect of APP (show APP Proteins) gene on synaptotagmin 1 mRNA level

  4. The major function of Ca2+ binding to synaptotagmin's C2A domain is to neutralize the negative charge of the pocket, thereby unleashing the fusion-stimulating activity of synaptotagmin.

  5. this study provided direct support for the hypothesis that plasma membrane penetration, specifically by the C(2)B domain of synaptotagmin, is the critical effector interaction for coupling Ca(2 (show CA2 Proteins)+) binding with vesicle fusion

  6. Results suggest that the tandem C2 domains of Syt 1 play independent roles in neurotransmission.

  7. The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo

  8. Synaptotagmins I and IV promote transmitter release independently of Ca(2 (show CA2 Proteins)+) binding in the C(2)A domain

  9. Data show that synaptotagmin I is required for a post-docking step during vesicle fusion but does not function to stabilize the docked vesicle state.

  10. These results indicate that synaptotagmin is the major Ca(2 (show CA2 Proteins)+) sensor for evoked release and functions to trigger synchronous fusion in response to Ca(2 (show CA2 Proteins)+), while suppressing asynchronous release.

Mouse (Murine) Synaptotagmin I (SYT1) interaction partners

  1. We conclude that synaptotagmin-1 phosphorylation is an essential step in PKC-dependent potentiation of synaptic transmission, acting downstream of the two other essential DAG/PKC substrates, Munc13-1 and Munc18-1 (show STXBP1 Proteins).

  2. data show that hepatic Syt1 expression is influenced by diet and hormonal milieu

  3. different structural states of syt (show SS18 Proteins) underlie the control of distinct forms of synaptic transmission.

  4. The interaction of Dvl1 (show DVL1 Proteins) with Syt-1, which is regulated by Wnts, modulates neurotransmitter release.

  5. Data (including data from studies in knockout mice) suggest that loss of both Syt1/Syt7 (show SYT7 Proteins) decreases capacity of readily-releasable pool (RRP (show RRBP1 Proteins)) of Ca2 (show CA2 Proteins)+ in synaptic vesicles without altering rate of priming into RRP (show RRBP1 Proteins); Syt1/Syt7 (show SYT7 Proteins) functions appear redundant.

  6. Syt-1 regulates Abeta (show APP Proteins) levels in mouse neurons. Knockdown of endogenous Syt-1 in mouse primary neurons led to a significant reduction in both Abeta40 and Abeta42 generation.

  7. Increased expression of Syt1 in neural stem cells is essential for neurogenesis progression.

  8. This study provides new insights in how the two opposite sides of the C2B domain of Synaptotagmin-1 participate in secretory vesicle fusion, and in more upstream steps, especially vesicle docking.

  9. atomic-resolution crystal structures of Ca(2 (show CA2 Proteins)+)- and Mg(2 (show MCOLN1 Proteins)+)-bound complexes between synaptotagmin-1 and the neuronal SNARE (show VTI1B Proteins) complex

  10. the Ca(2+) dependence of the interaction between PRIP-C2 and Syt1-C2A was attributed to Ca(2+) binding with Syt1-C2A, but not PRIP-C2, using a series of mutants prepared from both C2 domains.

Human Synaptotagmin I (SYT1) interaction partners

  1. These findings identify Syt1 as a novel Ca(2 (show CA2 Proteins)+)-sensitive PS1 (show PSEN1 Proteins) modulator that could regulate synaptic ABETA (show APP Proteins), opening avenues for novel and selective synapse targeting therapeutic strategies.

  2. One-Step reverse transcriptase real time PCR for the detection SYT (show SS18 Proteins)-SSX (show SSX2 Proteins) transcript is feasible as an aid in confirming the diagnosis of synovial sarcoma.

  3. membrane tethering by E-Syt1 (ER to PM) and by synaptotagmin (secretory vesicles to PM) undergo a similar regulation by plasma membrane lipids and cytosolic Ca(2 (show CA2 Proteins)+).

  4. A dominant negative de novo SYT1 missense variant(I368T)altered the kinetics of synaptic vesicle endocytosis and caused an early onset dyskinetic movement disorder, severe motor delay, and profound cognitive impairment.

  5. Data suggest that calcium-dependent phosphatidylinositol 4,5-diphosphate- (PI(4,5)P2-) binding proteins (such as SYT1, PRKCA (show PKCa Proteins) [protein kinase C alpha (show PKCa Proteins)], and ANXA2 (show ANXA2 Proteins) [annexin A2 (show ANXA2 Proteins)]) interactions with membrane microdomains are tightly regulated. [REVIEW]

  6. Whole genome analyses of a well-differentiated liposarcoma reveals novel SYT1 and DDR2 (show DDR2 Proteins) rearrangements.

  7. Hydrophobic interactions play a key role in Syt1 binding botulinum neurotoxin DC.

  8. Structural insights into the Ca2 (show CA2 Proteins)+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A (show RPH3A Proteins) and synaptotagmin 1.

  9. synaptotagmin-1 is involved in a rapid vesicular Ca(2 (show CA2 Proteins)) sequestration through a Ca(2 (show CA2 Proteins))/H antiport

  10. PRIP inhibits regulated exocytosis through the interaction of its C2 domain with syntaxin 1 (show STX1A Proteins) and SNAP-25 (show SNAP25 Proteins), potentially competing with accessory proteins such as synaptotagmin I and by directly inhibiting trans-SNARE (show NAPA Proteins) complex formation

Cow (Bovine) Synaptotagmin I (SYT1) interaction partners

SYT1 Protein Profile

Protein Summary

The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001

Gene names and symbols associated with Synaptotagmin I Proteins (SYT1)

  • Synaptotagmin 1 (Syt1)
  • synaptotagmin I (Syti)
  • synaptotagmin I (SYT1)
  • synaptotagmin-1 (Tsp_06980)
  • synaptotagmin-1 (Tsp_08220)
  • synaptotagmin 1 (syt1)
  • DKFZP459P193 protein (DKFZP459P193)
  • golgi reassembly stacking protein 1 (Gorasp1)
  • synaptotagmin I (Syt1)
  • synaptotagmin VIII (syt8)
  • synaptotagmin VIII (SYT8)
  • synaptotagmin-like 1 (SYTL1)
  • synaptotagmin, p65 (LOC100533340)
  • 5430411C10Rik protein
  • AW124717 protein
  • CG3139 protein
  • D. Syt I protein
  • DKFZP459P193 protein
  • Dmel\\CG3139 protein
  • Droso1 protein
  • DSypt protein
  • dSYT protein
  • dsyt1 protein
  • Dsyt2 protein
  • dsytI protein
  • G630098F17Rik protein
  • GB20036 protein
  • GOLPH5 protein
  • GRASP65 protein
  • l(2)23AB1 protein
  • l(2)23Ba protein
  • l(2)k05909 protein
  • p65 protein
  • SVP65 protein
  • syt protein
  • syt-1 protein
  • syt 1 protein
  • syt1 protein
  • syt I protein
  • Syti protein

Protein level used designations for Synaptotagmin I Proteins (SYT1)

CG3139-PA , CG3139-PB , CG3139-PC , CG3139-PE , CG3139-PF , CG3139-PG , Synaptotagmin-1 , Synaptotagmin-I , Synaptotagmin1 , SynaptotagminI , Syt1-PA , Syt1-PB , Syt1-PC , Syt1-PE , Syt1-PF , Syt1-PG , synaptoptagmin 1 , synaptotagmin , synaptotagmin 1 , synaptotagmin I , synaptotagmin-1 , DKFZP459P193 protein , Synaptotagmin I , Golgi reassembly-stacking protein 1 , golgi peripheral membrane protein p65 , golgi reassembly-stacking protein of 65 kDa , sytI , p65 , synaptotagmin p65 , synaptotagmin 8 , synaptotagmin I VQ/C2B-beta

33473 Drosophila melanogaster
408613 Apis mellifera
657877 Tribolium castaneum
751605 Taeniopygia guttata
10903271 Trichinella spiralis
10906784 Trichinella spiralis
100037879 Xenopus (Silurana) tropicalis
100189845 Pongo abelii
74498 Mus musculus
6857 Homo sapiens
20979 Mus musculus
25716 Rattus norvegicus
482579 Canis lupus familiaris
281511 Bos taurus
396083 Gallus gallus
100513599 Sus scrofa
100174463 Pongo abelii
695390 Macaca mulatta
570237 Danio rerio
423095 Gallus gallus
487346 Canis lupus familiaris
100511935 Sus scrofa
527641 Bos taurus
100533340 Aplysia californica
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