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TBC1 Domain Family, Member 4 Proteins (TBC1D4)

May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Additionally we are shipping TBC1D4 Antibodies (100) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TBC1D4 9882 O60343
TBC1D4 210789 Q8BYJ6
Rat TBC1D4 TBC1D4 306117  
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Top TBC1D4 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

TBC1D4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for TBC1 Domain Family, Member 4 (TBC1D4) Interaction Partners

Human TBC1 Domain Family, Member 4 (TBC1D4) interaction partners

  1. AS160 and TBC1D1 (show TBC1D1 Proteins) phosphorylations were evident 30 min after exercise.

  2. homozygous carriers of a nonsense p.Arg684Ter variant have markedly higher concentrations of plasma glucose and serum insulin 2 hours after an oral glucose load compared with individuals with other genotypes

  3. Findings suggest that a dampening of insulin (show INS Proteins)-induced phosphorylation of AS160 on specific sites in skeletal muscle contributes to the insulin (show INS Proteins) resistance evident in a sedentary aging population

  4. insulin (show INS Proteins) resistance in muscles from healthy individuals is associated with suppression of site-specific phosphorylation of AS160

  5. AS160 interacts with the large cytoplasmic NP domain of the alpha-subunit (show POLG Proteins) of the Na(+),K(+)-ATPase (show ATP1A1 Proteins). AMP (show APRT Proteins)-stimulated protein kinase (show CDK7 Proteins) (AMPK (show PRKAA1 Proteins)) and AS160 participate in a common pathway to modulate the cell surface expression of the Na(+),K(+)-ATPase (show ATP1A1 Proteins).

  6. Crystal structures of human TBC1D1 (show TBC1D1 Proteins) and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 (show SLC2A4 Proteins) translocation.

  7. AS160 phosphotyrosine-binding domain constructs inhibit insulin (show INS Proteins)-stimulated GLUT4 (show SLC2A4 Proteins) vesicle fusion with the plasma membrane

  8. Impaired insulin (show INS Proteins)-induced site-specific TBC1D4 phosphorylation may contribute to skeletal muscle insulin (show INS Proteins) resistance in type 2 diabetes.

  9. results show AS160 phosphorylation level is frequently increased in breast cancer; results implicate a possible role of AS160 in breast tumorigenesis and suggest that p-AS160 might be useful as a marker and a potential novel treatment target

  10. WNK1 promotes cell surface expression of glucose transporter GLUT1 by regulating a Tre-2/USP6-BUB2-Cdc16 domain family member 4 (TBC1D4)-Rab8A complex

Mouse (Murine) TBC1 Domain Family, Member 4 (TBC1D4) interaction partners

  1. As160 knockout mice have GLUT4 (show SLC2A4 Proteins) expression and glucose uptake defects in skeletal muscle and adipose tissue. These defects combine in AS160 KO/Tbc1d1 (show TBC1D1 Proteins) KO mice, supporting nonredundant functions for AS160 and Tbc1d1 (show TBC1D1 Proteins).

  2. AS160 has a direct role in linking the trafficking of Na(+),K(+)-ATPase (show ATP1A1 Proteins) to the energy state of renal epithelial cells

  3. TBC1D4 is dispensable for the regulation of renal Na+ and water transport, but may play a role for GLUT4 (show SLC2A4 Proteins)-mediated basolateral glucose uptake in distal tubules.

  4. The Thr649 phosphorylation of AS160/TBC1D4 by protein kinase B (show AKT1 Proteins) plays an important role in the heart electric conduction system through regulating the R-wave amplitude.

  5. AS160 forms a ternary complex with Fsp27 (show CIDEC Proteins) and Rab8a (show RAB8A Proteins) to positively regulate lipid droplets fusion.

  6. RAB10 (show RAB10 Proteins) and its GTPase-activating protein (show RASA1 Proteins) AS160 comprise the principal signaling module downstream of insulin receptor (show INSR Proteins) activation that regulates the accumulation of GLUT4 (show SLC2A4 Proteins) transport vesicles at the plasma membrane.

  7. Data show that the AS160-knockout mice exhibited insulin resistance in both muscle and liver in a euglycaemic clamp study.

  8. Constitutive targeting of AS160 to the plasma membrane increased the surface GLUT4 (show SLC2A4 Proteins) levels, and this was attributed to both enhanced AS160 phosphorylation and 14-3-3 (show YWHAQ Proteins) binding and inhibition of AS160 GAP activity.

  9. TBC1D4 may play an important role for the control of renal ion and water handling and hence for the control of extracellular fluid homeostasis.

  10. Because ClipR-59 (show CLIP3 Proteins) also interacts with Akt (show AKT1 Proteins) and enhances the interaction between Akt (show AKT1 Proteins) and AS160, we suggest that ClipR-59 (show CLIP3 Proteins) functions as a scaffold protein (show HOMER1 Proteins) to facilitate Akt (show AKT1 Proteins)-mediated AS160 phosphorylation, thereby regulating glucose transport

TBC1D4 Protein Profile

Protein Summary

May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.

Gene names and symbols associated with TBC1D4

  • TBC1 domain family, member 4 (TBC1D4)
  • TBC1 domain family, member 4 (Tbc1d4)
  • 5930406J04Rik protein
  • A930035N22 protein
  • As160 protein
  • AV295684 protein
  • RGD1561609 protein

Protein level used designations for TBC1D4

Acrg embryonic lethality minimal region ortholog , TBC (Tre-2, BUB2, CDC16) domain-containing protein , TBC1 domain family member 4 , akt substrate of 160 kDa

9882 Homo sapiens
210789 Mus musculus
100523015 Sus scrofa
534649 Bos taurus
306117 Rattus norvegicus
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