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TAC3 encodes a member of the tachykinin family of secreted neuropeptides. Additionally we are shipping Tachykinin 3 Kits (40) and Tachykinin 3 Proteins (16) and many more products for this protein.
Showing 10 out of 90 products:
Human Polyclonal Tachykinin 3 Primary Antibody for ICC, IHC (fro) - ABIN152542
Halasz, Zelena, Toth, Tulogdi, Mikics, Haller: Substance P neurotransmission and violent aggression: the role of tachykinin NK(1) receptors in the hypothalamic attack area. in European journal of pharmacology 2009
Show all 14 Pubmed References
Influence of age and 17beta-estradiol on kisspeptin, neurokinin B, and prodynorphin (show PDYN Antibodies) gene expression in the arcuate-median eminence.
This study showed a new evidence that furthers our understanding for the mechanisms underlying Tac2 (show TAC1 Antibodies)-dependent cellular pathways in fear learning.
Data show that estrogen receptor alpha (ERalpha (show ESR1 Antibodies)) in tachykinin 2 (show TAC1 Antibodies) protein (Tac2 (show TAC1 Antibodies)) neurons typically restrains pubertal onset and hypothalamic reproductive drive.
Tac2 (show TAC1 Antibodies)-/- females had delays in sexual maturation, with time to vaginal opening and first estrus occurring later than controls. However, cycling recovered in adulthood and Tac2 (show TAC1 Antibodies)-/- females were fertile, although they produced fewer pups per litter.
Increased Tac2 (show TAC1 Antibodies) expression, through a stress-induced PTSD-like model, or following lentiviral CeA (show CEA Antibodies) overexpression, are sufficient to enhance fear consolidation.
Data suggest that activation of neurokinin 3 and kappa-opioid receptors (NK3R (show TACR3 Antibodies) and KOR (show OPRK1 Antibodies)) excites and inhibits kisspeptin, neurokinin B (NKB), and dynorphin (KNDy neurons).
NKB could directly regulate secretion from NK3R-expressing GnRH neurons.
Tac2 (show TAC1 Antibodies) homozygous null mice responded normally to a series of algogenic (pain-inducing) and pruritic (itch-inducing) stimuli.
Preprotachykinin (show TAC1 Antibodies) (PPT)-B genes are expressed in uterine cells, oocytes, ovaries and embryos from mice, and may play a role in female reproductive function.
mutations in TAC (show IL2RA Antibodies) and TACR3 (show TACR3 Antibodies) are not a common cause for ICPP.
Colocalization experiments provided evidence for the presence of cocaine- and amphetamine-regulated transcript (show CARTPT Antibodies) (CART) in KP-immunoreactive (IR) and perikarya and in KP-IR and NKB-IR axon varicosities.
Amino acid substitution A63P in TAC3 gene was statistically associated with the puberty onset time in Chinese girls.
SP may influence the KP and NKB secretory output via additional autocrine/paracrine mechanisms or regulate GnRH neurosecretion directly.
Copper can enter cultured astrocytoma cells and subsequently open plasma membrane calcium channels, but when bound to NKB, copper ion uptake is inhibited.
Expression of the gene encoding NKB (TAC3) is up-regulated 20-fold in leiomyomas, compared with matched myometrium.
Rare variants in the TAC3 and TACR3 (show TACR3 Antibodies) genes were identified in patients with central pubertal disorders and loss-of-function variants of TACR3 (show TACR3 Antibodies) were associated with the normosmic IHH (show IHH Antibodies) phenotype.
these immunohistochemical data suggest an aging-related moderate enhancement in central NKB signaling.
NKB neurons in the arcuate nucleus do not synthesize detectable amounts of kisspeptin and dynorphin in young male humans. These data call for a critical use of the KNDy neuron terminology when referring to the pulse generator of the hypothalamus
NKB/NK(3)R and kisspeptin/KISS1R (show KISS1R Antibodies) are present in female peripheral reproductive tissues with colocalization of both systems in some non-neuronal cell populations of the human female genital tract.
This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded protein is primarily expressed in the central and peripheral nervous system and functions as a neurotransmitter. This protein is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternate splicing results in multiple transcript variants.
, neurokinin B
, preprotachykinin B
, tachykinin 3 (neuromedin K, neurokinin beta)
, neurokinin 2
, neurokinin A
, neurokinin B-like protein Zneurok1
, neurokinin alpha
, neuromedin L
, neuropeptide K
, substance K
, gamma tachykinin 3
, neuromedin K
, tachykinin 2
, neurokinin B, neuromedin K
, tachykinin 3, neurokinin beta