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TXLNG encodes a member of the taxilin family. Additionally we are shipping Taxilin gamma Antibodies (29) and many more products for this protein.
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We propose that maximal transcriptional repression by FIAT requires its interaction with SUMOylated, HDAC2 (show HDAC2 Proteins)-interacting aNAC (show NACa2 Proteins)
The bone phenotype of compound Naca (show NACa1 Proteins)(+/-); Fiat(+/-) heterozygotes confirms that FIAT and alphaNAC are part of a common genetic pathway and support a role for the FIAT/alphaNAC interaction in normal bone physiology.
an interplay between Sp1 (show SP1 Proteins) and Sp3 as a mechanism involved in the control of Fiat gene expression in osteoblasts.
FIAT can both modulate early osteoblast activity by interacting with ATF4 (show ATF4 Proteins) and regulate later osteoblast function through inhibition of FRA-1 (show FOSL1 Proteins).
Upregulation of MLrgW and MLrgS may be an important component of the LPS (show TLR4 Proteins) inflammatory pathway and of the host response to infection with gram-negative bacteria .
These results show that FIAT regulates bone mass accrual and establish FIAT as a novel transcriptional regulator of osteoblastic function.(FIAT protein, mouse)
inhibition of FIAT expression increases ATF4 (show ATF4 Proteins) activity and confirm the important role of FIAT in osteoblast function
[review] First evidence of a functional interaction between ATF4 (show ATF4 Proteins), FIAT (factor-inhibiting ATF4-mediated transcription) and alphaNAC (nascent polypeptide-associated complex (show NACa1 Proteins) and coactivator alpha).
identification of isoforms of taxilin; interaction with syntaxin; tissue distribution [beta-taxilin (show TXLNB Proteins), gamma-taxilin].
evaluation of the effects of a novel environmental lipopolysaccharide-responding (Elrg) gene on the regulation of proliferation and cell cycle of the hepatoma-derived cell line, HepG2
This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, taxilin gamma
, factor inhibiting ATF4-mediated transcription
, factor inhibiting activating transcription factor 4 (ATF4)-mediated transcription
, lipopolysaccharide-responsive gene protein
, lipopolysaccharide-specific response protein 5
, environmental LPS-responding
, environmental lipopolysaccharide-responding gene protein
, lipopolysaccharide specific response-5 protein