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The protein encoded by TET2 is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. Additionally we are shipping TET2 Antibodies (121) and many more products for this protein.
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Deregulated BCL6 (show BCL6 ELISA Kits) expression caused by hypermethylation and TET2 mutations may result in skewed follicular helper T cell differentiation and eventually contribute to angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma development in patients
Our results confirmed that TET2 is frequently mutated in Taiwanese patients with chronic myelomonocytic leukemia
Endogenous TET2 bound the androgen receptor (AR) and AR-coactivator proteins in LNCaP cell extracts, and TET2 KD increases prostate-specific antigen (KLK3/PSA) expression.
TET2 mutation occurred in some populations of DLBCL patients and was likely involved in the pathogenesis of their malignancies
This article focuses mainly on the biological aspects of TET2 mutations, followed by a brief review of recent progress in our understanding of their epigenetic aspects in hematologic malignancies. [review]
We found that TET1 and TET2 messenger RNA expression was lower and TET3 (show TET3 ELISA Kits) was higher in cancers compared to normal tissues. Positive correlation between 5-hmC and the relative expression of TET1 and TET2 was found, but no correlation was observed in the case of TET3 (show TET3 ELISA Kits).
review examines mutant IDH1 (show IDH1 ELISA Kits)/2 and TET2 enzymes in the context of responses to DNA damage and their potential involvement in age-related genomic instability.
Hypermethylation and downregulation of TET2 gene may play a role in predisposition to childhood ALL.
TET2 mutations are likely to be acquired at the common myeloid/lymphoid progenitor levels
this study found a novel hereditary susceptible factor-TET2 rs3733609 C/T variant for the development of Myeloproliferative neoplasms, suggesting the variant may be partially responsible for the pathogenesis and accumulation of Myeloproliferative neoplasms.
TET2 plays a role in the iron and heme metabolism in erythroblasts.
the effects of vitamin C inhibiting the apo(a (show APOA ELISA Kits)) expression were attenuated by ELK1siRNA and Tet2siRNA. These results suggested vitamin C down-regulate apo(a (show APOA ELISA Kits)) expression via Tet2-dependent DNA demethylation in HepG2 cells
Reprogramming of spermatogonial stem cells from Tet1 and Tet2 double knockout mice however lacked demethylation of H19 (show NCKAP1 ELISA Kits) imprinting control regions.
The critical roles of TET1/2 individually.
the stability of Foxp3 (show FOXP3 ELISA Kits) expression is markedly compromised in T reg (show KCNH2 ELISA Kits) cells from Tet2/Tet3 (show TET3 ELISA Kits) double-deficient mice.
Tet2 was responsible for increase in 5-hydroxymethylcytosine abundance after ischemic injury.
These results uncover the hypermethylation of DNA methylation (show HELLS ELISA Kits) canyons as the genomic key feature of Tet1/Tet2 double-knockout mouse embryonic fibroblasts.
our results indicate that neuronal TET2 is positively involved in the regulation of cell survival.
UNG (show UNG ELISA Kits) might be involved in Tet-mediated DNA demethylation.
Findings indicate a novel type of hematological malignancy induced by tet oncogene 2 protein (Tet2) loss.
The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene.
methylcytosine dioxygenase TET2
, probable methylcytosine dioxygenase TET2
, tet oncogene family member 2
, tet oncogene 2