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TXNRD2 encodes a member of the family of pyridine nucleotide oxidoreductases. Additionally we are shipping Thioredoxin Reductase 2 Antibodies (65) and Thioredoxin Reductase 2 Proteins (9) and many more products for this protein.
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Evidence that the rs4485648 polymorphism of the TrxR2 gene might exert an independent effect on the development of Diabetic retinopathy.
Data suggest that TXNRD2 may represent a druggable target that could be deployed to reduce the development of fatal pulmonary metastases in patients with osteosarcoma (OS).
A meta-analysis of the top SNPs identified three new associated loci in primary open angle glaucoma--TXNRD2, ATXN2 (show ATXN2 ELISA Kits), and FOXC1 (show FOXC1 ELISA Kits)
The TXNRD2 rs 1548357 polymorphism might be a genetic risk factor for Myocardial infarction in subjects with T2 Diabetes mellitus of Slovenian origin.
Data suggest TXNRD1 (show TXNRD1 ELISA Kits) and TXRNRD2 function at the top of a redox pyramid that governs the oxidation state of peroxiredoxins and other protein factors, thereby dictating a hierarchy of phenotypic responses to oxidative insults.
Absence of TXNRD2 in humans leads to glucocorticoid deficiency.
Single Nucleotide Polymorphisms in the genes GPX1 (show GPX1 ELISA Kits) (rs1050450, rs1800668 and rs3811699), TrxR2 (rs5748469), and DIO2 (show DIO2 ELISA Kits) (rs225014) may not be significantly associated with Kashin-Beck disease in a Tibetan population.
Development of subcutaneous fibrosis can be associated with genetic variation in the mitochondrial enzyme TXNRD2, critically involved in removal of ROS (show ROS1 ELISA Kits), and maintenance of the intracellular redox balance.
Data suggest that dietary factor (selenium supplementation) up-regulates endogenous antioxidant systems and protects trophoblasts from oxidative stress; selenium upregulates GPX1 (glutathione peroxidase 1 (show GPX1 ELISA Kits)) and thioredoxin (show TXN ELISA Kits) reductases (TXNRD1 (show TXNRD1 ELISA Kits); TXNRD2).
A role of GPx2 (show GPX2 ELISA Kits), TrxR2 and TrxR3 (show TXNRD3 ELISA Kits) in proliferation, apoptosis and, therefore, also during cancer development.
Suggest role for Txnrd2 in sustaining heart function during aging and suggest that Txnrd2 may be a modifier of heart failure.
Regulatory link was discovered between mitochondrial Txnrd and the JNK (show MAPK8 ELISA Kits)-PHD2 (show EGLN1 ELISA Kits)-Hif-1alpha (show HIF1A ELISA Kits) axis, which highlights how the loss of Txnrd2 and the resulting altered mitochondrial redox balance impairs tumor growth as well as tumor-related angiogenesis.
The SirT1 (show SIRT1 ELISA Kits) regulates the expression of several antioxidant genes in bovine aortic endothelial cells, including Mn superoxide dismutase (show SOD2 ELISA Kits), catalase (show CAT ELISA Kits), peroxiredoxins 3 and 5, thioredoxin 2 (show TXN2 ELISA Kits), thioredoxin reductase 2, and uncoupling protein 2 (show UCP2 ELISA Kits).
Data indicate that mammalian thioredoxin reductase (H-TrxR) reduces hypothiocyanous acid (HOSCN).
Txnrd2 exerts a crucial function during postischemic reperfusion via thiol regeneration.
Energization of mitochondria increases the antioxidant potential of the TrxR2/Trx2 (show TXN2 ELISA Kits) system and that inhibition of TrxR2 results in increased H(2)O(2) emission.
Genomic organization and identification of a novel alternative splicing variant of mouse mitochondrial TrxR2 gene
Neither Trx2 (show TXN2 ELISA Kits) nor TrxR2 gain of function modified the redox regulation of mitochondria-dependent apoptosis in cos-7 cells, Hela cells and Mouse Neuro2a cells.
Cardiac tissue-restricted ablation of thioredoxin reductase 2 results in fatal dilated cardiomyopathy
Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. This gene partially overlaps the COMT gene on chromosome 22.
, thioredoxin reductase
, selenoprotein Z
, thioredoxin reductase 2, mitochondrial
, thioredoxin reductase 3
, thioredoxin reductase TR3
, thioredoxin reductase beta
, TR beta