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Topoisomerase (DNA) II beta 180kDa Proteins (TOP2B)

TOP2B encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. Additionally we are shipping Topoisomerase (DNA) II beta 180kDa Antibodies (58) and Topoisomerase (DNA) II beta 180kDa Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TOP2B 21974 Q64511
Rat TOP2B TOP2B 361100  
TOP2B 7155 Q02880
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Top Topoisomerase (DNA) II beta 180kDa Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 16 Days

TOP2B Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)
Human ,

More Proteins for Topoisomerase (DNA) II beta 180kDa (TOP2B) Interaction Partners

Mouse (Murine) Topoisomerase (DNA) II beta 180kDa (TOP2B) interaction partners

  1. TOP2beta as a factor involved in regulating granulosa cell genomic integrity and follicle atresia.

  2. Results identified topoisomerase IIbeta (Top2beta) as a novel determinant for camptothecin sensitivity.

  3. Top IIbeta might be a down-stream target of Nurr1 (show NR4A2 Proteins), which might influence the processes of axon genesis in dopaminergic neurons via the regulation of TOP IIbeta expression.

  4. Findings suggest a chromatin-based targeting of Top2beta to regulatory regions in the genome to govern the transcriptional program associated with neuronal differentiation and longevity.

  5. Data suggest that activity of TOP2B in elongating spermatids is strongly inhibited by PARP1 (show PARP1 Proteins) and PARP2 (show PARP2 Proteins), and this is in turn counteracted by the PAR (show AFG3L2 Proteins)-degrading activity of PAR (show AFG3L2 Proteins) glycohydrolase.

  6. proteasomal degradation of TOP2beta induced by the TOP2-DNA covalent complex or the TOP2 circular clamp is due to transcriptional arrest but not DNA damage

  7. DNA topoisomerase II beta deficiency severely affects cerebral cortex stratification: no subplate is discernible, and neurons born at later stages of corticogenesis fail to migrate to the superficial layers.

  8. A nuclear matrix-associated (show SMARCA5 Proteins) topoisomerase IIB (TOP2B) interacting with an extracellular Mn2+/Ca2 (show CA2 Proteins)+-dependent nuclease (show DCLRE1C Proteins) cleaves sperm DNA into loop-sized fragments.

  9. These results suggest that the defect in establishing neuromuscular junctions in top2beta knockout mice could be due to the lack of TopIIbeta-mediated neurite outgrowth.

  10. VP-16-induced carcinogenesis involves mainly the beta rather than the alpha isozyme of Top2 (show TOP2 Proteins); VP-16-induced DNA sequence rearrangements and double-strand breaks are found to be Top2beta-dependent

Human Topoisomerase (DNA) II beta 180kDa (TOP2B) interaction partners

  1. during early development, TOP2A (show TOP2A Proteins) is likely to have a role in cell proliferation, whereas TOP2B is expressed in post-mitotic cells and may be important in controlling expression of long genes even at this early stage.

  2. Cinobufacini inhibited the proliferation of the HepG-2 cells induced apoptosis in a dose- and time-dependent manner and downregulated the mRNA and protein expression levels of TOPO I (show TOP1 Proteins) and TOPO II (show TOP2 Proteins)

  3. A direct interaction between Ku70 (show XRCC6 Proteins)/86 and BRG1 (show SMARCA4 Proteins) brings together SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) remodeling capabilities and TOP2beta activity to enhance the transcriptional response to hormone stimulation.

  4. Human cytomegalovirus IE1 exon 4 interacts with Topoisomerase IIbeta (TOPOIIbeta), whose activity is required for viral genome persistence and maintenance via binding to a cis (show CISH Proteins)-acting viral maintenance element.

  5. Proteolytic degradation of Top2 (show TOP2A Proteins) enables the processing of Top2 (show TOP2A Proteins).DNA and Top2 (show TOP2A Proteins).RNA covalent complexes by TDP2 (show TDP2 Proteins).

  6. There is an association between chemosensitivity and Pgp (show PGPEP1 Proteins), GST-pi (show GSTP1 Proteins) and Topo II (show TOP2 Proteins) expression in gastric cancer.

  7. Top2beta-DNA cleavage complexes arrest transcription elongation and induce a proteasomal degradation of Top2beta on DNA.

  8. Overexpression of Lewis(y) antigen confers cell adhesion-mediated drug resistance to apoptosis in ovarian cancer cells by the upregulation of Topo-I (show TOP1 Proteins) and Topo-II beta.

  9. Tyrosine 656 in topoisomerase II beta is important for the catalytic activity of the enzyme.

  10. Data show significant associations between SNPs in RARA (show RARA Proteins), RARB (show RARB Proteins), TOP2B and RARG (show RARG Proteins), RXRA (show RXRA Proteins), TLR3 (show TLR3 Proteins), TRIM5 (show TRIM5 Proteins) and RIG-I (show DDX58 Proteins) genes and rubella virus-specific cytokine immune responses.

Topoisomerase (DNA) II beta 180kDa (TOP2B) Protein Profile

Protein Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants\; however, the second variant has not yet been fully described.

Gene names and symbols associated with TOP2B

  • topoisomerase (DNA) II beta 180kDa (TOP2B)
  • topoisomerase (DNA) II beta (Top2b)
  • D230016L12Rik protein
  • Top-2 protein
  • TOP2B protein
  • top2beta protein
  • TOPIIB protein

Protein level used designations for TOP2B

topoisomerase (DNA) II beta 180kDa , DNA topoisomerase II, beta isozyme , DNA topoisomerase 2-beta , topoisomerase II beta , DNA topoisomerase II beta , DNA topoisomerase II, 180 kD , U937 associated antigen , antigen MLAA-44 , topo II beta , topoisomerase IIb , DNA topoisomeraseII_beta , topoisomerase II beta-2

460232 Pan troglodytes
21974 Mus musculus
361100 Rattus norvegicus
7155 Homo sapiens
395966 Gallus gallus
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