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TOP2B Products

(Topoisomerase (DNA) II beta 180kDa (TOP2B))
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants\; however, the second variant has not yet been fully described. [provided by RefSeq, Jul 2008].

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Featured TOP2B Categories

TOP2B Antibodies

High quality antibodies with extensive validation data.

TOP2B ELISA Kits

Reliable ELISA kits for a wide range of species.

TOP2B Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TOP2B Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IP, IHC (p), WB
Validations
  • (3)
Cat. No. ABIN2855447
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, ICC, IF, IHC, WB
Validations
  • (3)
Cat. No. ABIN6265674
Quantity 100 μL
Datasheet Datasheet
Reactivity Dog, Human, Monkey, Pig
Application IC, IF, IHC, WB
Validations
  • (3)
Cat. No. ABIN2707765
Quantity 200 μL
Datasheet Datasheet

Recommended TOP2B ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970755
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6960050
Quantity 96 tests
Datasheet Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1381563
Quantity 96 tests
Datasheet Datasheet

Recommended TOP2B Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3095950
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3135606
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1323349
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our TOP2B products

Ali, Biswas, Pal: "HSF1 mediated TNF-α production during proteotoxic stress response pioneers proinflammatory signal in human cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 33, Issue 2, pp. 2621-2635, (2019) (PubMed).

Hu, Shiflett, Kobayashi, Chao, Wilson, Mohr, Huang: "TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency." in: Molecular cell, Vol. 74, Issue 3, pp. 466-480.e4, (2019) (PubMed).

Hedayati, Haffner, Coulter, Raval, Zhang, Zhou, Mian, Knight, Razavi, Dalrymple, Isaacs, Santos, Hales, Nelson, Yegnasubramanian, DeWeese: "Androgen Deprivation Followed by Acute Androgen Stimulation Selectively Sensitizes AR-Positive Prostate Cancer Cells to Ionizing Radiation." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 22, Issue 13, pp. 3310-9, (2016) (PubMed).

Aviner, Shenoy, Elroy-Stein, Geiger: "Uncovering Hidden Layers of Cell Cycle Regulation through Integrative Multi-omic Analysis." in: PLoS genetics, Vol. 11, Issue 10, pp. e1005554, (2015) (PubMed).

Maxwell, Pelka, Tam, El-Osta: "Chromatin context and ncRNA highlight targets of MeCP2 in brain." in: RNA biology, Vol. 10, Issue 11, pp. 1741-57, (2014) (PubMed).

Elliott, Crawford, Mulligan, Summerfield, Newton, Wallis, Mainou-Fowler, Evans, Bedwell, Durkacz, Willmore: "Mitoxantrone in combination with an inhibitor of DNA-dependent protein kinase: a potential therapy for high risk B-cell chronic lymphocytic leukaemia." in: British journal of haematology, Vol. 152, Issue 1, pp. 61-71, (2010) (PubMed).

Barajon, Serrao, Arnaboldi, Opizzi, Ripamonti, Balsari, Rumio: "Toll-like receptors 3, 4, and 7 are expressed in the enteric nervous system and dorsal root ganglia." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 57, Issue 11, pp. 1013-23, (2009) (PubMed).

Shain, Landowski, Dalton et al.: "Adhesion-mediated intracellular redistribution of c-Fas-associated death domain-like IL-1-converting enzyme-like inhibitory protein-long confers resistance to CD95-induced apoptosis in hematopoietic ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 5, pp. 2544-53, (2002) (PubMed).

Suzuki, Tomida, Tsuruo: "Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia." in: Oncogene, Vol. 20, Issue 41, pp. 5779-88, (2001) (PubMed).

Brown, Holden, Rahn, Perkins: "Immunohistochemical staining for DNA topoisomerase IIa in Hodgkin's disease." in: American journal of clinical pathology, Vol. 109, Issue 1, pp. 39-44, (1998) (PubMed).

Synonyms and alternative names related to TOP2B

DNA topoisomerase II beta (TOP2B), topoisomerase (DNA) II beta (Top2b), DNA topoisomerase II beta (Top2b), microRNA 4442 (MIR4442), D230016L12Rik, Top-2, TOP2B, top2beta, TOPIIB

Protein level used designations for TOP2B

  • topoisomerase (DNA) II beta 180kDa
  • DNA topoisomerase II, beta isozyme
  • DNA topoisomerase 2-beta
  • topoisomerase II beta
  • DNA topoisomerase II beta
  • DNA topoisomerase II, 180 kD
  • U937 associated antigen
  • antigen MLAA-44
  • topo II beta
  • topoisomerase IIb
  • DNA topoisomeraseII_beta
  • topoisomerase II beta-2
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