Tubulin-Specific Chaperone E Proteins (TBCE)

Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates.

list all proteins Gene Name GeneID UniProt
Human TBCE TBCE 6905 Q15813
TBCE 361255 Q5FVQ9
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Catalog No. Origin Source Conjugate Quantity Supplier Delivery Price Details
Yeast Rat His tag 1 mg Log in to see 60 to 71 Days

TBCE Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

More Proteins for Tubulin-Specific Chaperone E (TBCE) Interaction Partners

Human Tubulin-Specific Chaperone E (TBCE) interaction partners

  1. Although loss of function of TBCE has been documented to impact multiple developmental processes, the present findings provide evidence that hypomorphic TBCE mutations primarily drive neurodegeneration

  2. Sanjad-Sakati syndrome molecular pathology has been shown to be due to mutations in the TBCE gene on chromosome 1q42-q43.

  3. the role of the human TBCE and TBCB (show TBCB Proteins) chaperones in alpha-tubulin (show TUBA4A Proteins)-beta-tubulin (show TUBB Proteins) dissociation, was investigated.

  4. tudies confirmed elevated expression of three target antigens RAB38, TBCE, and DUSP12 in CML.

  5. TBCE has a role in membrane trafficking in the Golgi and late endosomal compartments, tubulin (show TUBB Proteins) assembly, and the development of the parathyroid

  6. Tbce is critical for the maintenance of microtubules in mouse motor axons

  7. The tubulin-specific chaperone E (Tbce) mutation described here suggests that alterations in tubulin (show TUBB Proteins) assembly lead to retrograde degeneration of motor axons, ultimately resulting in motoneuron cell death.

  8. Reviews recent findings on the molecular mechanisms of the development of the parathyroid glands, with special emphasis on the possible role of tubulin chaperone E (TBCE), implicated in the hypopathyroidism, retardation and dysmorphism (HRD) syndrome.

  9. TBCE, TBCB (show TBCB Proteins) and alpha-tubulin (show TUBA4A Proteins) form a ternary complex after heterodimer dissociation. These complexes might serve to escort alpha-tubulin (show TUBA4A Proteins) towards degradation or recycling, depending on the cell requirements.

  10. Depletion of Op18 (show STMN1 Proteins) by means of RNA interference increased the susceptibility of tubulin (show TUBB Proteins) to TBCE or E-like (show TBCEL Proteins) mediated disruption, while overexpressed Op18 (show STMN1 Proteins) exerted a tubulin (show TUBB Proteins)-protective effect.

TBCE Protein Profile

Protein Summary

Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex\; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with TBCE

  • tubulin folding cofactor E (TBCE)
  • tubulin folding cofactor E (Tbce)
  • HRD protein
  • KCS protein
  • KCS1 protein
  • pac2 protein

Protein level used designations for TBCE

Kenny-Caffey syndrome , tubulin-folding cofactor E , tubulin-specific chaperone E , beta-tubulin cofactor E

6905 Homo sapiens
505066 Bos taurus
361255 Rattus norvegicus
100172438 Pongo abelii
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