Tumor Protein P63 Proteins (TP63)

TP63 encodes a member of the p53 family of transcription factors. Additionally we are shipping p63 Antibodies (71) and p63 Kits (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TP63 21454 P11983
TP63 8626 Q9H3D4
TP63 246334 Q9JJP6
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Top p63 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag,His tag 100 μg Log in to see 20 to 21 Days
$437.80
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,976.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$310.00
Details

TP63 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, ,
Rat (Rattus)

Top referenced p63 Proteins

  1. Human p63 Protein expressed in Wheat germ - ABIN1323400 : Huang, Jeong, Okamura, Sook-Kim, Zhu, Guerrero-Preston, Ratovitski: Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance. in Cell cycle (Georgetown, Tex.) 2012 (PubMed)

  2. Human p63 Protein expressed in Baculovirus infected Insect Cells - ABIN2005583 : Crum, McKeon: p63 in epithelial survival, germ cell surveillance, and neoplasia. in Annual review of pathology 2010 (PubMed)

More Proteins for Tumor Protein P63 (TP63) Interaction Partners

Horse (Equine) Tumor Protein P63 (TP63) interaction partners

  1. p63 expression was significantly lower in the chronic laminitic hoof than in that of control horses

Mouse (Murine) Tumor Protein P63 (TP63) interaction partners

  1. these results therefore highlight an unanticipated role for p53 (show TP53 Proteins) family proteins in a regulatory network that integrates essential Wnt (show WNT2 Proteins)-Tcf (show HNF4A Proteins) and nodal-Smad (show SMAD1 Proteins) inputs.

  2. the double mutant spermatocytes apoptosed at late pachynema because of sex body deficiency; thus p53 (show TP53 Proteins) and TAp63 are dispensable for arrest caused by sex body defects. These data affirm that recombination-dependent and sex body-deficient arrests occur via genetically separable mechanisms.

  3. TGFb3 (show TGFB3 Proteins)-induced down-regulation of p63 (show CKAP4 Proteins) in the medial edge epithelia of the palatal shelves is a pre-requisite for palatal fusion by facilitating periderm migration from, and reducing the proliferative potential of, the midline epithelial seam thereby preventing cleft palate.

  4. miR-20a-5p contributes to hepatic glycogen synthesis through targeting p63 to regulate p53 and PTEN expression.

  5. this study shows that CCTalpha (show PCYT1A Proteins) is required for antigen-specific, germinal center-derived memory B cells

  6. Taken together, these data show that p63 (show CKAP4 Proteins) regulates the self-renewal and differentiation of oesophageal stem cells in humans and mice.

  7. IL-6 (show IL6 Proteins)/P-STAT3 (show STAT3 Proteins) activation influences p63 (show CKAP4 Proteins) isoform expression in healing wounds, which may contribute to wound-induced hair follicle neogenesis.

  8. In vivo inhibition of both p63 (show CKAP4 Proteins) and p73 (show ARHGAP24 Proteins) in combination accelerates tumor regression and increases survival of p53 (show TP53 Proteins)-deficient mice.

  9. Data show that T-complex protein 1 (TCP-1) may be a crucial downstream molecule of purinergic receptor P2X 7 (show P2RX7 Proteins) (P2X7R (show P2RX7 Proteins)) and plays a role in lymphoid neoplasm metastasis.

  10. The data presented here reveal an additional level of interplay between CCT (show FLVCR2 Proteins) and actin mediated via gelsolin (show GSN Proteins), suggesting that CCT (show FLVCR2 Proteins) may influence processes depending on gelsolin (show GSN Proteins) activity, such as cell motility.

Human Tumor Protein P63 (TP63) interaction partners

  1. The findings demonstrate that miR (show MLXIP Proteins)-203a plays an essential role in keratinocyte proliferation and differentiation caused by extracellular calcium by targeting the SNAI2 (show SNAI2 Proteins) and DeltaNp63 genes.

  2. Immunohistochemical detection of thyroid transcription factor 1 (show NKX2-1 Proteins), Napsin A (show NAPSA Proteins), and P40 (show IL9 Proteins) fragment of TP63 can be used in the subclassification of non-small cell lung carcinomas.

  3. CK5 (show KRT5 Proteins) and p40 (show IL9 Proteins) are good diagnostic markers for squamous cell carcinoma and superior to p63 (show RPE65 Proteins)

  4. nectin-1 (show PVRL1 Proteins) is expressed in human hair follicles and there is a p63 (show RPE65 Proteins)-responsive element in the NECTIN1 promoter

  5. these findings suggest that constitutive TG2 (show TGM2 Proteins) expression results in stabilization of DeltaNp63alpha, leading to maintenance of epidermal squamous cell carcinoma cancer stem cell properties and enhanced tumor formation

  6. High TP63 expression is associated with colorectal cancer.

  7. Data show that p63 transcription factors modulate cell migration via Src-focal adhesion kinase (FAK) signaling in foreskin keratinocytes (HFK) expressing human papilloma virus (HPV)16 E6/E7 genes.

  8. Taken together, these data show that p63 (show RPE65 Proteins) regulates the self-renewal and differentiation of oesophageal stem cells in humans and mice.

  9. identified a novel genome-wide significant association between SNPs located in an intronic TP63 enhancer and CL/P

  10. ACTL6A (show BAF53A Proteins) and p63 (show RPE65 Proteins) collaborate as oncogenic drivers in head and neck squamous cell carcinoma (HNSCC).

Zebrafish Tumor Protein P63 (TP63) interaction partners

  1. they unravel essential roles of TAp63 and p53 (show TP53 Proteins) to promote both keratinocyte proliferation and their terminal differentiation by promoting Notch (show NOTCH1 Proteins) signalling and caspase 3 (show CASP3 Proteins) activity.

  2. the p63 transcription factor is upregulated to initiate this apoptotic pathway and directly activates puma (show BBC3 Proteins) transcription in response to ER stress.

  3. Early zebrafish embryos express a dominant-negative form of p63 (DeltaNp63), which accumulates in the nucleus just as epidermal growth begins. (p63)

  4. DeltaNp63 expression blocks neural development and promotes nonneural development, even in the absence of Bmp signaling. (DeltaNp63)

  5. rps19 (show RPS19 Proteins)-deficient phenotype is mediated by dysregulation of deltaNp63 and p53 (show TP53 Proteins) and results in hematopoietic and developmental abnormalities resembling Diamond-Blackfan anemia

Xenopus laevis Tumor Protein P63 (TP63) interaction partners

  1. Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.

  2. The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4 (show BMP4 Proteins).

  3. The role of p63 as a negative Wnt (show WNT2 Proteins)-regulator thus matches with the frequently observed downregulation of p63 during tumor progression, when cancer cells adopt a more mesenchymal, invasive phenotype.

p63 (TP63) Protein Profile

Protein Summary

This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.

Gene names and symbols associated with Tumor Protein P63 Proteins (TP63)

  • tumor protein p63 (TP63)
  • tumor protein p63 (tp63)
  • tumor protein p63 (LOC100227936)
  • tumor protein p73-like (LOC100393670)
  • tumor protein p73-like (LOC100433100)
  • tumor protein p73-like (LOC100480840)
  • tumor protein p73-like (LOC100496308)
  • tumor protein p73-like (LOC100512967)
  • tumor protein p73-like (LOC100545037)
  • tumor protein p73-like (LOC100577122)
  • tumor protein p73-like (LOC100594205)
  • tumor protein p73-like (LOC100611345)
  • tumor protein p73-like (LOC100624851)
  • tumor protein p73-like (LOC100648488)
  • t-complex protein 1 (Tcp1)
  • transformation related protein 63 (Trp63)
  • tumor protein p63 (Tp63)
  • tumor protein p63-like (LOC100355881)
  • AI462811 protein
  • AI528772 protein
  • AIS protein
  • B(p51A) protein
  • B(p51B) protein
  • c-cpn protein
  • CCT protein
  • Cct1 protein
  • Ccta protein
  • DNp63 protein
  • EEC3 protein
  • id:ibd3516 protein
  • ket protein
  • LMS protein
  • NBP protein
  • np63 protein
  • OFC8 protein
  • p40 protein
  • p51 protein
  • P51/P63 protein
  • p53CP protein
  • P63 protein
  • p73H protein
  • p73L protein
  • RHS protein
  • SHFM4 protein
  • Tcp-1 protein
  • TP53CP protein
  • TP53L protein
  • Tp63 protein
  • tp73l protein
  • tp73l-A protein
  • TRic protein
  • Trp53rp1 protein
  • TRP63 protein
  • wu:fc89f04 protein
  • wu:fk85h07 protein
  • wu:fk88b02 protein
  • Xp63 protein

Protein level used designations for Tumor Protein P63 Proteins (TP63)

tumor protein p63 , tumor protein 63 , p63 gamma , tumor protein p73-like , tumor protein 63-like , CCT-alpha , T-complex protein 1 subunit alpha , T-complex protein 1 subunit alpha A , T-complex protein 1 subunit alpha B , TCP-1-A , TCP-1-B , TCP-1-alpha , t-complex polypeptide 1 , tailless complex polypeptide 1A , tailless complex polypeptide 1B , transformation-related protein 63 , CUSP , amplified in squamous cell carcinoma , chronic ulcerative stomatitis protein , keratinocyte transcription factor KET , tumor protein p53-competing protein , tumor protein p63 deltaN isoform delta , transformation related protein 63 , tumor protein 63 kDa , delta-Np63 , fc89f04

GENE ID SPECIES
100059752 Equus caballus
100170632 Oryzias latipes
703997 Macaca mulatta
100048992 Ovis aries
460930 Pan troglodytes
100227936 Taeniopygia guttata
100386953 Callithrix jacchus
100393670 Callithrix jacchus
100433100 Pongo abelii
100444448 Pongo abelii
100480840 Ailuropoda melanoleuca
100496308 Xenopus (Silurana) tropicalis
100512967 Sus scrofa
100545037 Meleagris gallopavo
100577122 Apis mellifera
100594205 Nomascus leucogenys
100606847 Nomascus leucogenys
100611345 Pan troglodytes
100624851 Sus scrofa
100648488 Bombus terrestris
21454 Mus musculus
22061 Mus musculus
8626 Homo sapiens
246334 Rattus norvegicus
260407 Danio rerio
373640 Xenopus laevis
374269 Gallus gallus
100732143 Cavia porcellus
100625258 Sus scrofa
488125 Canis lupus familiaris
615335 Bos taurus
101108874 Ovis aries
100355881 Oryctolagus cuniculus
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