Ubiquitin Specific Peptidase 15 Proteins (USP15)

USP15 encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. Additionally we are shipping USP15 Antibodies (89) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
USP15 9958 Q9Y4E8
Mouse USP15 USP15 14479 Q8R5H1
Rat USP15 USP15 171329  
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Top USP15 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$510.36
Details

USP15 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,

More Proteins for Ubiquitin Specific Peptidase 15 (USP15) Interaction Partners

Human Ubiquitin Specific Peptidase 15 (USP15) interaction partners

  1. We show that PRP31, a component of U4 snRNP, is modified with K63-linked ubiquitin chains by the PRP19 complex and deubiquitinated by USP15 and its substrate targeting factor SART3. USP15SART3 makes a complex with USP4 and this ternary complex serves as a platform to deubiquitinate PRP31 and PRP3

  2. TGF-b promotes the translation of USP15 through activation of mammalian target of rapamycin (show FRAP1 Proteins) by the phosphoinositide 3-kinase/AKT (show AKT1 Proteins) pathway. Upregulation of USP15 translation links the crosstalk between TGF-beta (show TGFB1 Proteins) signaling and p53 (show TP53 Proteins) stability, allowing this cytokine to have a critical role in cancer progression.

  3. We concluded that USP15 attenuates IGF-I (show IGF1 Proteins) signaling by antagonizing Nedd4 (show NEDD4 Proteins)-induced IRS-2 (show IRS2 Proteins) ubiquitination.

  4. These results uncover a new regulatory mechanism that USP15 activates Nrf1 (show NFE2L1 Proteins) against the beta-TrCP (show BTRC Proteins) inhibition to maintain proteostasis.

  5. Study identified USP15 as having recurrent de novo loss of function mutations and discovered evidence supporting two other known genes with recurrent de novo variants (FOXP1 (show FOXP1 Proteins) and KDM5B (show KDM5B Proteins)).

  6. crystal structures of SART3 (show SART3 Proteins) in the apo (show C9orf3 Proteins)-form and in complex with the DUSP (show DUSP5 Proteins)-UBL domain of USP15 at 2.0 and 3.0 A, respectively. Structural analysis reveals SART3 (show SART3 Proteins) contains 12 half-a-tetratricopeptide (HAT (show MGEA5 Proteins)) repeats, organized into two subdomains, HAT (show MGEA5 Proteins)-N and HAT (show MGEA5 Proteins)-C. SART3 (show SART3 Proteins) dimerizes through the concave surface of HAT (show MGEA5 Proteins)-C, whereas the HAT (show MGEA5 Proteins)-C convex surface binds USP15 in a novel bipartite mode.

  7. SMURF2 (show SMURF2 Proteins) is a critical target of USP15 in the TGF-beta (show TGFB1 Proteins) signaling pathway.

  8. our data demonstrate that USP15 acts as a negative regulator of RIG-I (show DDX58 Proteins) signaling via DUB-dependent and independent mechanisms.

  9. These data identify USP15 as an antagonist of Parkin (show PARK2 Proteins) and suggest that USP15 inhibition could be a therapeutic strategy for PD cases caused by reduced Parkin (show PARK2 Proteins) levels.

  10. Data show that USP15 enhances BMP-induced phosphorylation of SMAD1 (show GARS Proteins) by interacting with and deubiquitylating ALK3 (show BMPR1A Proteins).

Mouse (Murine) Ubiquitin Specific Peptidase 15 (USP15) interaction partners

  1. In hematopoietic cells and in resident brain cells, USP15 was coexpressed with, and functionally acted together with the E3 ubiquitin ligase (show MUL1 Proteins) TRIM25 (show TRIM25 Proteins) to positively regulate type I interferon (show IFNA Proteins) responses and to promote pathogenesis during neuroinflammation.

  2. T cell intrinsic USP15 deficiency causes excessive production of IFN-gamma (show IFNG Proteins), which promotes an immunosuppressive tumor microenvironment during MCA (show RSPH1 Proteins)-induced primary tumorigenesis.

  3. Both mouse and human have 22 exons with identical splice sites and an exon/intron structure identical to the mouse Usp4 (show USP4 Proteins) gene.

USP15 Protein Profile

Protein Summary

This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2.

Gene names and symbols associated with USP15

  • ubiquitin specific peptidase 15 (USP15)
  • universal stress protein (usp15)
  • ubiquitin specific peptidase 15 (usp15)
  • ubiquitin specific peptidase 15 (LOC100224751)
  • ubiquitin specific peptidase 15 (Usp15)
  • 4921514G19Rik protein
  • AI327321 protein
  • E430033I05Rik protein
  • Gcap18 protein
  • mKIAA0529 protein
  • Ubp109 protein
  • UNP protein
  • UNPH-2 protein
  • UNPH4 protein
  • USP15 protein

Protein level used designations for USP15

ubiquitin specific peptidase 15 , universal stress protein , ubiquitin carboxyl-terminal hydrolase 15-like , ubiquitin carboxyl-terminal hydrolase 15 , ubiquitin specific protease 15 , ubiquitous nuclear protein , Deubiquitinating enzyme 15 , Ubiquitin thioesterase 15 , Ubiquitin-specific-processing protease 15 , deubiquitinating enzyme 15 , ubiquitin thioesterase 15 , ubiquitin-specific-processing protease 15 , ubiquitin thiolesterase 15 , granule cell antiserum positive 18 , deubiquitinating enzyme Ubp109 , ubiquitin carboxyl-terminal hydrolase of 109 kDa

GENE ID SPECIES
716793 Macaca mulatta
3128959 Haloarcula marismortui ATCC 43049
100090554 Ornithorhynchus anatinus
100464241 Ailuropoda melanoleuca
395644 Gallus gallus
452035 Pan troglodytes
100012616 Monodelphis domestica
100055857 Equus caballus
100158604 Xenopus (Silurana) tropicalis
100224751 Taeniopygia guttata
100356438 Oryctolagus cuniculus
100412030 Callithrix jacchus
100454837 Pongo abelii
100542201 Meleagris gallopavo
100554748 Anolis carolinensis
100586852 Nomascus leucogenys
538284 Bos taurus
9958 Homo sapiens
14479 Mus musculus
474424 Canis lupus familiaris
100524085 Sus scrofa
171329 Rattus norvegicus
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