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Ubiquitin Specific Peptidase 15 Proteins (USP15)

USP15 encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. Additionally we are shipping USP15 Antibodies (93) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
USP15 9958 Q9Y4E8
Mouse USP15 USP15 14479 Q8R5H1
Rat USP15 USP15 171329  
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Top USP15 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

USP15 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,

More Proteins for Ubiquitin Specific Peptidase 15 (USP15) Interaction Partners

Human Ubiquitin Specific Peptidase 15 (USP15) interaction partners

  1. SMURF2 (show SMURF2 Proteins) is a critical target of USP15 in the TGF-beta (show TGFB1 Proteins) signaling pathway.

  2. our data demonstrate that USP15 acts as a negative regulator of RIG-I (show DDX58 Proteins) signaling via DUB-dependent and independent mechanisms.

  3. These data identify USP15 as an antagonist of Parkin (show PARK2 Proteins) and suggest that USP15 inhibition could be a therapeutic strategy for PD cases caused by reduced Parkin (show PARK2 Proteins) levels.

  4. Data show that USP15 enhances BMP-induced phosphorylation of SMAD1 (show GARS Proteins) by interacting with and deubiquitylating ALK3 (show BMPR1A Proteins).

  5. Data suggest that ubiquitin specific peptidase 15 (USP15) may play a role in the pathogenesis of psoriasis through regulating the type I TGFbeta (show TGFB1 Proteins) receptor (TbetaR-I (show TGFBR1 Proteins))/Smad7 (show SMAD7 Proteins) pathway.

  6. Data indicate ubiquitin-specific protease 15 (USP15) as a critical regulator of the tripartite motif protein 25 (TRIM25 (show TRIM25 Proteins))- and RNA sensor retinoic acid-inducible gene-I (RIG-I (show DDX58 Proteins))-mediated antiviral immune response.

  7. USP15 deficiency promoted T cell activation in vitro and enhanced T cell responses to bacterial infection and tumor challenge in vivo.

  8. SART3 (show SART3 Proteins) recruits ubH2B, which may be evicted from DNA during transcription, for deubiquitination by Usp15

  9. The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exit.

  10. USP15 specifically deubiquitinates Keap1 (show KEAP1 Proteins), which suppresses the Nrf2 (show GABPA Proteins) pathway.

Mouse (Murine) Ubiquitin Specific Peptidase 15 (USP15) interaction partners

  1. T cell intrinsic USP15 deficiency causes excessive production of IFN-gamma (show IFNG Proteins), which promotes an immunosuppressive tumor microenvironment during MCA (show RSPH1 Proteins)-induced primary tumorigenesis.

  2. Both mouse and human have 22 exons with identical splice sites and an exon/intron structure identical to the mouse Usp4 (show USP4 Proteins) gene.

USP15 Protein Profile

Protein Summary

This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2.

Gene names and symbols associated with USP15

  • ubiquitin specific peptidase 15 (USP15)
  • universal stress protein (usp15)
  • ubiquitin specific peptidase 15 (usp15)
  • ubiquitin specific peptidase 15 (LOC100224751)
  • ubiquitin specific peptidase 15 (Usp15)
  • 4921514G19Rik protein
  • AI327321 protein
  • E430033I05Rik protein
  • Gcap18 protein
  • mKIAA0529 protein
  • Ubp109 protein
  • UNP protein
  • UNPH-2 protein
  • UNPH4 protein
  • USP15 protein

Protein level used designations for USP15

ubiquitin specific peptidase 15 , universal stress protein , ubiquitin carboxyl-terminal hydrolase 15-like , ubiquitin carboxyl-terminal hydrolase 15 , ubiquitin specific protease 15 , ubiquitous nuclear protein , Deubiquitinating enzyme 15 , Ubiquitin thioesterase 15 , Ubiquitin-specific-processing protease 15 , deubiquitinating enzyme 15 , ubiquitin thioesterase 15 , ubiquitin-specific-processing protease 15 , ubiquitin thiolesterase 15 , granule cell antiserum positive 18 , deubiquitinating enzyme Ubp109 , ubiquitin carboxyl-terminal hydrolase of 109 kDa

716793 Macaca mulatta
3128959 Haloarcula marismortui ATCC 43049
100090554 Ornithorhynchus anatinus
100464241 Ailuropoda melanoleuca
395644 Gallus gallus
452035 Pan troglodytes
100012616 Monodelphis domestica
100055857 Equus caballus
100158604 Xenopus (Silurana) tropicalis
100224751 Taeniopygia guttata
100356438 Oryctolagus cuniculus
100412030 Callithrix jacchus
100454837 Pongo abelii
100542201 Meleagris gallopavo
100554748 Anolis carolinensis
100586852 Nomascus leucogenys
538284 Bos taurus
9958 Homo sapiens
14479 Mus musculus
474424 Canis lupus familiaris
100524085 Sus scrofa
171329 Rattus norvegicus
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