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The protein encoded by UBE2K belongs to the ubiquitin-conjugating enzyme family. Additionally we are shipping Ubiquitin-Conjugating Enzyme E2K Antibodies (113) and Ubiquitin-Conjugating Enzyme E2K Proteins (22) and many more products for this protein.
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Human UBE2K ELISA Kit for Sandwich ELISA - ABIN420224
Loeffler, Smith, Coffey, Aasly, LeWitt: CSF Nrf2 and HSPA8 in Parkinson's disease patients with and without LRRK2 gene mutations. in Journal of neural transmission (Vienna, Austria : 1996) 2016
The crystal structure of a Ube2K~ubiquitin conjugate has been described, and it was shown that even though it is monomeric, Ube2K can synthesize Lys48-linked ubiquitin chains.
Hip2, a ubiquitin-conjugating enzyme (show Ube2t ELISA Kits), can overcome radiation-induced G2/M cell cycle arrest and trigger the entry into mitosis.
An extract of bark from the tropical rainforest plant Byrsonima crassifolia was screened for inhibition of diubiquitin (show UBD ELISA Kits) formation by the human ubiquitin-conjugating enzyme E2-25K.
one of the roles of the C-terminal UBA domain, in the context of E2-25K, is to increase processivity in Lys48-linked polyubiquitin (show UBB ELISA Kits) chain synthesis, possibly through increased binding to the ubiquitinated substrate.
Results suggest that the interaction between E2-25K and UBB (show UBB ELISA Kits)(+1) is critical for the synthesis and accumulation of UBB (show UBB ELISA Kits)(+1)-anchored polyubiquitin (show UBB ELISA Kits), which results in proteasomal inhibition and neuronal cell death.
This study suggests that Hip2 might be involved in the regulation of Smac (show DIABLO ELISA Kits)-mediated apoptosis.
Results suggest that in permeabilized, US11-expressing cells polyubiquitination of the MHC class I heavy chain substrate can be catalyzed by E2-25K.
E2-25K is involved in aggregate formation of expanded polyglutamine proteins and polyglutamine-induced cell death.
E2-25K has a crucial role in oxidative stress and cerebral Ischemia/Reperfusion-induced damage through inhibiting proteasome via its SUMOylation.
E2-25K/Hip-2 is thus an essential upstream regulator of the expression and activation of caspase-12 (show CASP12 ELISA Kits) in endoplasmic reticulum stress-mediated Abeta (show APP ELISA Kits) neurotoxicity.
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene.
ubiquitin-conjugating enzyme E2K (UBC1 homolog)
, huntingtin interacting protein 2
, ubiquitin-conjugating enzyme E2-25K
, ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
, ubiquitin-conjugating enzyme E2 K
, ubiquitin-conjugating enzyme E2-25 kDa
, huntingtin-interacting protein 2
, ubiquitin carrier protein
, ubiquitin-conjugating enzyme E2(25K)
, ubiquitin-conjugating enzyme E2-25 KDA
, ubiquitin-protein ligase