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Uncoupling Protein 1 (Mitochondrial, Proton Carrier) Proteins (UCP1)

Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). Additionally we are shipping UCP1 Antibodies (108) and UCP1 Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UCP1 7350 P25874
UCP1 22227 P12242
UCP1 24860 P04633
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Top UCP1 Proteins at

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Mouse His tag   100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 16 Days
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 16 Days

UCP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) Interaction Partners

Arabidopsis thaliana Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) interaction partners

  1. The transcriptome of overexpressing plants revealed a broad induction of stress-responsive genes not strictly related to the mitochondrial antioxidant machinery, suggesting that overexpression of AtUCP1 imposes a strong stress response within the cell.

  2. Foliar NO3 (-) assimilation was enhanced in both aox1a and ucp1 compared with the wild-type, suggesting that foliar NO3 (-) assimilation is probably driven by a decreased capacity of mAET and an increase in reductant within the cytosol.

  3. Overexpression of UCP1 in the mitochondrial inner membrane induced increased uncoupling respiration, decreased reactive pxygen species accumulation under abiotic stresses, and diminished cellular ATP content.

  4. The main physiological role of UCP1 in Arabidopsis leaves is related to maintaining the redox poise of the mitochondrial electron transport chain to facilitate photosynthetic metabolism. [AtUCP1]

Pig (Porcine) Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) interaction partners

  1. Data indicate that the abundance of uncoupling protein 1 (UCP1) was significantly reduced in the intrauterine growth restriction (IUGR) piglets.

  2. An alignment with human UCP1 revealed that exons 3 to 5 were eliminated by a deletion in the pig sequence.

Human Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) interaction partners

  1. In inguinal white adipose tissue (iWAT) of mice fed a high-fat diet (HFD), Ucp1 level decreases concomitantly with increases in Cnot7 (show CNOT7 Proteins) and its interacting partner Tob (show TDO2 Proteins).

  2. Findings suggest that polymorphisms in SIRT6 (show SIRT6 Proteins)/UCP1 genes may be important for increased carotid plaque burden and echodensity

  3. UCP1 -3826 A>G polymorphism is associated with weight, body fat mass, and risk of type 2 diabetes mellitus in obese individuals candidates for bariatric surgery.

  4. UCP1 and UCP3 expression is associated with lipid and carbohydrate oxidation in patients submitted to bariatric surgery.

  5. this study reveals that human adipose-derived stromal/progenitor cells can be readily differentiated into beige adipocytes that, upon activation, undergo uncoupling protein 1-dependent thermogenesis.

  6. This study suggests that the SNP rs1800592 in the UCP1 gene is associated with increased risk of PDR in the Chinese type 2 diabetes mellitus population.

  7. Genotype and allele distributions of UCP1, UCP2 and UCP3 polymorphisms did not differ significantly between obese and non-obese Type 2 Diabetes Mellitus patients.[Meta-analysis]

  8. Uncoupling protein 1 binds one nucleotide per monomer and is stabilized by tightly bound cardiolipin.

  9. Meta-analysis. There was no significant association of the UCP1-3826A/G polymorphism with BMI mean differences.

  10. By the application of these findings, we demonstrate that UCP1 is functionally thermogenic in intact brite adipocytes and adrenergic UCP1 activation is largely dependent on adipose triglyceride lipase (ATGL (show PNPLA2 Proteins)) rather than hormone sensitive lipase (HSL (show LIPE Proteins)).

Mouse (Murine) Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) interaction partners

  1. Metabolically inert perfluorinated fatty acids directly activate brown adipose tissue UCP1.

  2. Mice acclimatized to thermoneutrality revealed that Cpt2A-null interscapular brown adipose tissue failed to induce the expression of thermogenic genes such as Ucp1 and Pgc1a.

  3. Data show that fish oil intake increased oxygen consumption and rectal temperature, with concomitant upregulation of mitochondrial uncoupling protein 1 (show SLC25A19 Proteins) (UCP1) and beta3 adrenergic receptor (show ADRB3 Proteins) (beta3AR).

  4. Skin temperature in the interscapular region of neonates was lower in uncoupling protein 1 knockout pups employed as a positive control, but not in Cox7a1 (show COX7A1 Proteins) knockout pups

  5. PKA-dependent IRE1alpha (show ERN1 Proteins)-XBP1 (show XBP1 Proteins) activation is crucial for the transcriptional induction of Ucp1 in brown adipocytes.

  6. FGF21 (show FGF21 Proteins)-mediated improvements in clearance of a glucose challenge require UCP1.

  7. Data suggest beta-adrenergic activation of brown adipocytes leads to dissociation of Hdac1 (show HDAC1 Proteins) from promoters of Ucp1/Pgc1a, to up-regulation of histone H3 (show HIST3H3 Proteins) acetylation, to dissociation of polycomb (show CBX2 Proteins) repressive complexes, and to up-regulation of thermogenesis.

  8. thermogenic mitochondrial reactive oxygen species alter the redox status of cysteine thiols in brown adipose tissue to drive increased respiration, and that Cys253 of UCP1 is a key target

  9. abundance decreased even more in cold-acclimated UCP1 knockout mice

  10. These data indicate that several important metabolic endpoints of FGF21 (show FGF21 Proteins) are UCP1 independent

Cow (Bovine) Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) interaction partners

  1. UCPs do have uncoupling properties when expressed in mitochondria but that uncoupling by UCP1 or UCP2 (show UCP2 Proteins) does not prevent acute substrate-driven endothelial cell superoxide as effluxed from mitochondria respiring in vitro.

  2. These results suggest that CIDE-A (show CIDEA Proteins) and UCP1 are regulated by insulin (show INS Proteins) and/or fatty acids in mammary epithelial cells and lactating mammary glands, and thereby play an important role in lipid and energy metabolism.

UCP1 Protein Profile

Protein Summary

Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.

Gene names and symbols associated with UCP1

  • uncoupling family protein PUMP2 (PUMP1)
  • uncoupling protein 1 (mitochondrial, proton carrier) (UCP1)
  • uncoupling protein 1 (UCP1)
  • uncoupling protein 1 (mitochondrial, proton carrier) (ucp1)
  • uncoupling protein 1 (mitochondrial, proton carrier) (Ucp1)
  • AI385626 protein
  • ATPUMP1 protein
  • ATUCP1 protein
  • plant uncoupling mitochondrial protein 1 protein
  • Slc25a7 protein
  • Ucp protein
  • UCP1 protein
  • Ucpa protein
  • Uncp protein

Protein level used designations for UCP1

uncoupling protein 1 (mitochondrial, proton carrier) , uncoupling protein 1 , mitochondrial brown fat uncoupling protein 1 , solute carrier family 25 member 7 , thermogenin , UCP 1 , uncoupling protein 1 UCP1 , uncoupling protein 1, mitochondrial , uncoupling protein, mitochondrial , mitochondrial, proton carrier , Solute carrier family 25 member 7 , Thermogenin

824578 Arabidopsis thaliana
461504 Pan troglodytes
574124 Macaca mulatta
751863 Sus scrofa
100036979 Xenopus laevis
100135179 Xenopus (Silurana) tropicalis
7350 Homo sapiens
403574 Canis lupus familiaris
22227 Mus musculus
24860 Rattus norvegicus
281561 Bos taurus
100328618 Oryctolagus cuniculus
101835783 Mesocricetus auratus
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