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UMOD encodes uromodulin, the most abundant protein in normal urine. Additionally we are shipping Uromodulin Antibodies (177) and Uromodulin Kits (40) and many more products for this protein.
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These data demonstrate that the membrane-bound serine protease hepsin (show HPN Proteins) is the enzyme responsible for the physiological cleavage of uromodulin.
In essential hypertension there's a close negative relationship between lowered urine UMOD and increased serum inflammatory cytokines.
the crystal structures of polymerization regions of human UMOD and mouse ZP2 (show ZP2 Proteins), an essential sperm receptor (show ZP3 Proteins) protein that is structurally related to UMOD but forms heteropolymers, are reported.
UMOD: A significant effect of the rare p.V458L variant on the value of estimated glomerular filtration in elderly population was found.
The main and new finding of this study is the association of bilateral small caliber non-arteriosclerotic renal arteries with hyperuricemia due to a novel UMOD mutation causing intracellular accumulation of UMOD in distal tubular cells.
Suggest that uromodullin may have a renal physiologic function related to its inhibitory effect on the NFkappaB pathway.
Here, we reviewed the signal transduction pathway of UMOD and its role in the pathogenesis of kidney diseases. [review]
Uromodulin has greater immunosuppressive activities than THP and lower inductive property in relation to activation of immune cells.
UMOD does not play a role in IgA nephropathy pathogenesis nor progression.
Wild-type uromodulin was efficiently trafficked to the cell surface in transfected tsA (show PRDX2 Proteins) 201 cells, whereas the mutants were partially retained within the cell, and incompletely processed
we show that Tamm-Horsfall protein deficiency stimulates proximal epithelial activation of the Interleukin-23/Interleukin-17 (show IL17A Proteins) axis and systemic neutrophilia.
TNFalpha (show TNF Proteins) regulates uromodulin expression in a homeostatic setting, but the impact of TNFalpha (show TNF Proteins) on uromodulin during kidney injury is superseded by other factors that could inhibit HNF1beta (show HNF1B Proteins)-mediated expression of uromodulin.
AGP was more effective in limiting hepatic inflammation and maintaining perfusion than saline or HAS, in both endotoxemic and septic mice. AGP sequestration of LPS (show TLR4 Proteins) may contribute to its anti-inflammatory effects.
UMOD upregulates TRPV5 (show TRPV5 Proteins) by decreasing caveolin-1 (show CAV1 Proteins) dependent endocytosis of TRPV5 (show TRPV5 Proteins).
UMOD regulates sodium uptake in the thick ascending limb of the loop of Henle by modulating the effect of tumor necrosis factor-alpha (show TNF Proteins) on NKCC2A expression, making UMOD an important determinant of blood pressure control.
Genetic susceptibility link to hypertension and chronic kidney disease to uromodulin expression and uromodulin's effect on salt reabsorption in the kidney.
Using an ischemia-reperfusion model of murine acute kidney injury, we show that, while THP expression in thick ascending loop is downregulated at the peak of injury, it is significantly upregulated 48 h after.
Quercetin has the uricosuric and nephroprotective actions mediated by regulating the expression levels of renal organic ion transporters and UMOD.
a unifying model that underscores the role of THP as a major regulator of renal and systemic immunity.
Molecular and cellular effects of Tamm-Horsfall protein mutations and their rescue by chemical chaperones.
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
, Tamm-Horsfall urinary glycoprotein
, tamm-Horsfall urinary glycoprotein
, uromodulin (uromucoid, Tamm-Horsfall glycoprotein)
, Urmodulin (Tamm-Horsfall protein)
, uromucoid, human : Tamm-Horsfall glycoprotein