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The protein encoded by VAMP2 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Additionally we are shipping VAMP2 Antibodies (102) and VAMP2 Proteins (12) and many more products for this protein.
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findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 (show NCS1 ELISA Kits) in mitochondrial function via its association with several mitochondrial proteins.
The balance between synaptophysin (show SYP ELISA Kits) and sybII levels is critical for the correct targeting of sybII to synaptic vesicles and suggests that alterations in synaptophysin (show SYP ELISA Kits) levels might affect the localisation of sybII and subsequent presynaptic performance.
Thus, lipid-anchored syb2 provides little or no support for exocytosis, and anchoring syb2 to a membrane by a TMD (show TTN ELISA Kits) greatly improves its function
Vamp2 mutations impair the ability of Munc18-1 (show STXBP1 ELISA Kits) to promote trans-SNARE (show VTI1B ELISA Kits) zippering. These mutations inhibit spontaneous as well as evoked neurotransmitter release, providing evidence for the Vamp2-regulating function of Munc18-1 (show STXBP1 ELISA Kits) in synaptic exocytosis.
These results provide a novel molecular mechanism for autocrine negative feedback regulation of insulin (show INS ELISA Kits) secretion.
Results suggest that side chains in the syb2 transmembrane domain influence the kinetics of exocytosis by perturbing the packing of the surrounding lipids
we demonstrate that Syb2 and SNAP25 (show SNAP25 ELISA Kits) mediate the vesicular release of BDNF (show BDNF ELISA Kits) in axons and dendrites of cortical neurons
Here we report on transgenic mice expressing a ubiquitinated synaptic vesicle protein (Ub(G76V)-GFP-Syb2) that develop progressive degeneration of motor nerve terminals.
VAMP2 is the major v-SNARE (show GOSR1 ELISA Kits) involved in GLUT4 (show SLC2A4 ELISA Kits) trafficking to the surface of 3T3-L1 adipocytes.
These results indicate a role for the syb2 TMD in nascent fusion pores, but in a very different structural arrangement from that of the syntaxin transmembrane domains.
Data show a significant increase of vesicle-associated membrane protein 2 (VAMP-2) mRNA expression, however, the expressions of synaptosome-associated protein of 25 kDa (SNAP-25 (show SNAP25 ELISA Kits)) and syntaxin 1A (show STX1A ELISA Kits) did not exhibit the changes in hippocampus.
This study showed that decreased Levels of VAMP2 correlate with Duration of Dementia.
VAMP2-NRG1 (show NRG1 ELISA Kits) is a novel oncogenic fusion gene representing a new addition to the list of NRG1 (show NRG1 ELISA Kits) fusion genes, which together may form an important diagnostic and clinical category of lung adenocarcinoma cases
A large vesicular pool of VAMP2 maintained by AP180 (show SNAP91 ELISA Kits) is crucial to sustain efficient neurotransmission.
SNARE (show NAPA ELISA Kits) complex genes and their interactions may play a significant role in susceptibility and working memory of ADHD.
miR (show MLXIP ELISA Kits)-206 regulates lung surfactant secretion by limiting the availability of VAMP-2 protein.
The genetic variations of VAMP2, Synaptotagmin XI (show SYT11 ELISA Kits) might be indication of the relationship between these genes and idiopathic generalized epilepsy
BoNT/F5 cleaves substrate synaptobrevin-2 in a different location than the other BoNT/F subtypes, between (54)L and (55)E.
unique mechanism of SNARE (show NAPA ELISA Kits) motif-dependent endocytic sorting and identify the ANTH domain proteins AP180 (show SNAP91 ELISA Kits) and CALM as cargo-specific adaptors for synaptobrevin 2 endocytosis
VAMP2 mediates the trafficking of alpha5beta1 integrin to the plasma membrane and VAMP2-dependent integrin trafficking is critical in cell adhesion, migration and survival.
SNAP-23 (show SNAP23 ELISA Kits) and syntaxin-4 (show STX4 ELISA Kits) are expressed in human eosinophils and are likely candidates for association with VAMP-2 during docking, which is followed by exocytosis
VAMP-2 is critical to lysosome fusion in membrane raft clustering, and this VAMP-2-mediated lysosome-MR signalosomes contribute to redox regulation of coronary endothelial function.
VAMP2 is restricted from forming the SNARE (show NAPA ELISA Kits) (soluble N-ethylmaleimide-sensitive fusion protein (show NSF ELISA Kits) attachment protein receptor) complex in chromaffin granules from adrenal medullae to the same degree as in brain-purified synaptic vesicles.
Lengthening juxtamembrane region of synaptobrevin-2 severely reduced occurrence of rapid single events, leaving slow ones unchanged. It also impaired increase in fast-fusion mode that normally follows elevation of intracellular Ca2 (show CA2 ELISA Kits)+ levels.
The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG.
vesicle-associated membrane protein 2 (synaptobrevin 2)
, synaptobrevin II
, vesicle-associated membrane 2
, Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2)
, Vesicle-associated membrane protein (synaptobrevin 2)
, synaptobrevin 2
, vesicle associated membrane protein 2
, vesicle-associated membrane protein 2