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gamma-Glutamyl Carboxylase Proteins (GGCX)

GGCX encodes an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Additionally we are shipping GGCX Antibodies (64) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GGCX 2677 P38435
GGCX 56316 Q9QYC7
GGCX 81716 O88496
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Top GGCX Proteins at

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days

GGCX Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)
Rat (Rattus)

More Proteins for gamma-Glutamyl Carboxylase (GGCX) Interaction Partners

Human gamma-Glutamyl Carboxylase (GGCX) interaction partners

  1. 529 adults (n = 325 European-Americans, 204 Egyptians) on a stable warfarin dose were genotyped for GGCX rs12714145 and rs10654848, FPGS (show FPGS Proteins) rs7856096, and STX1B (show STX1B Proteins) rs4889606.

  2. GGCX c.2084+45G polymorphisms has a moderate effect on VKAs dose requirements in Slavic population from Central-Eastern Europe.

  3. Detected are ten mutations in the gamma-glutamyl carboxylase gene in patients with hereditary deficiency of vitamin K-dependent coagulation factors.

  4. The allele frequency for GGCX 12970 C > G is 1.43 in north Indians and did not have a significant bearing on the maintenance dose of acenocoumarol oral anticoagulant in cardiac valve replacement patients.

  5. GGCX mutation found in families with pseudoxanthoma elasticum with retinitis pigmentosa and cutis laxa.

  6. These findings indicate that individuals carrying the CYP2C19 (show CYP2C19 Proteins) rs3814637CC or CYP2C9 (show CYP2C9 Proteins) rs1057910AA or GGCX rs699664AA genotype needed higher warfarin doses in the Chinese population.

  7. In atrial fibrillation population in Xinjiang, patients with CT and TT genotypes in the gamma-glutamyl carboxylase gene rs259251 loci required significantly higher warfarin dose than those with CC genotype.

  8. evaluation of urinary Gla (show NAT8 Proteins) excretion in relation with apo E (show APOE Proteins) genotype

  9. study demonstrated the effects of SNP (974G>A) in the GGCX gene on the correlation between dietary vitamin K intake and gamma-carboxylation of serum osteocalcin (show BGLAP Proteins)

  10. there may be no significant association between the low activity and mutation of GGCX in calcium oxalate urolithiasis

Mouse (Murine) gamma-Glutamyl Carboxylase (GGCX) interaction partners

  1. GGCX in osteoblasts functions to prevent abnormal mineralization in bone formation.

  2. findings suggest that GGCX expressed in osteoblasts is critical for the maintenance of blood glucose and WAT

  3. OCN is gamma-carboxylated by the gamma-carboxylase (GGCX) on three glutamic acid residues, a cellular process requiring reduction of vitamin K by a second enzyme, VKORC1 (show VKORC1 Proteins).

  4. Ggcx(Deltaliver/Deltaliver) mice displayed bleeding diathesis.

  5. Effect of vitamin K-dependent protein precursor propeptide, vitamin K hydroquinone, and glutamate (show GRIN1 Proteins) substrate binding on the structure and function of {gamma}-glutamyl carboxylase.

  6. These findings suggest a role for both the GGCX gene and the genetic background as well as dietary factors in modulating the phenotypic severity of Pseudoxanthoma elasticum caused by loss-of-function mutations in ABCC6 (show ABCC6 Proteins).

  7. Analysis of a Ggcx(+/-) intercross revealed a partial developmental block with only 50% of expected Ggcx(-/-) offspring surviving to term, with the latter animals dying uniformly at birth of massive intra-abdominal hemorrhage

GGCX Protein Profile

Protein Summary

This gene encodes an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GGCX

  • gamma-glutamyl carboxylase (GGCX)
  • gamma-glutamyl carboxylase (ggcx)
  • gamma-glutamyl carboxylase (GC)
  • gamma-glutamyl carboxylase (sce5891)
  • gamma-glutamyl carboxylase (Ggcx)
  • cb751 protein
  • CG13927 protein
  • dgammaC protein
  • dGC protein
  • Dmel\\CG13927 protein
  • gammaC protein
  • GGC protein
  • ggcx protein
  • si:ch1073-230p18.3 protein
  • VKCFD1 protein
  • zgc:158736 protein

Protein level used designations for GGCX

gamma-glutamyl carboxylase , vitamin K-dependent gamma-carboxylase , peptidyl-glutamate 4-carboxylase , vitamin K gamma glutamyl carboxylase , CG13927-PA , CG13927-PB , GC-PA , GC-PB , gamma-glutamyl-carboxylase , gamma glutamyl carboxylase

459364 Pan troglodytes
557240 Danio rerio
695628 Macaca mulatta
780874 Ciona intestinalis
100144666 Xenopus (Silurana) tropicalis
100171564 Pongo abelii
38194 Drosophila melanogaster
5810488 Sorangium cellulosum So ce56
444473 Xenopus laevis
2677 Homo sapiens
281190 Bos taurus
56316 Mus musculus
81716 Rattus norvegicus
475769 Canis lupus familiaris
443129 Ovis aries
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