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anti-serglycin (SRGN) Antibodies

SRGN encodes a protein best known as a hematopoietic cell granule proteoglycan. Additionally we are shipping serglycin Proteins (11) and serglycin Kits (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SRGN 5552 P10124
SRGN 19073 P13609
SRGN 56782 P04917
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Top anti-serglycin Antibodies at

Showing 10 out of 45 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated EIA, FACS, WB Flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram) using Serglycin / PRG1 Antibody (C-term), followed by FITC-conjugated goat-anti-rabbit secondary antibodies. Western blot analysis in Hela cell line lysates (35ug/lane) using Serglycin / PRG1 Antibody (C-term). This demonstrates the Serglycin antibody detected the Serglycin protein (arrow). 0.4 mL Log in to see 6 to 8 Days
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: SRGN Antibody [NBP1-80886] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10. Lane 2: Human cell line HL-60. Immunohistochemistry: SRGN Antibody [NBP1-80886] - Staining of human bone marrow shows strong cytoplasmic positivity in subsets of bone marrow poietic cells. 0.1 mL Log in to see 8 to 11 Days
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated FACS, WB SRGN Antibody (C-term) (ABIN656226) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the SRGN antibody detected the SRGN protein (arrow). 400 μL Log in to see 10 to 11 Days
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged SRGN is 0.3 ng/ml as a capture antibody. Western Blot detection against Immunogen (43.12 KDa) . 100 μg Log in to see 9 Days
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
Human Rabbit Un-conjugated IF, IHC, WB Western blot analysis of extracts of various cell lines, using SRGN antibody. Immunohistochemistry of paraffin-embedded human liver injury using SRGN antibody at dilution of 1:200 (40x lens). 100 μL Log in to see 14 Days
Mouse Rabbit Un-conjugated ICC, IHC, IP, WB 100 μg Log in to see 11 to 13 Days

SRGN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , ,
, , , , ,
Mouse (Murine) ,

Rat (Rattus) ,

Top referenced anti-serglycin Antibodies

  1. Human Polyclonal SRGN Primary Antibody for EIA, FACS - ABIN954731 : Ma, Rudd, Edner, Gavhed, Ramme, Fadeel, Nordenskjöld, Henter, Zheng: Sequence analysis of the SRGN, AP3B1, ARF6, and SH2D1A genes in familial hemophagocytic lymphohistiocytosis. in Pediatric blood & cancer 2008 (PubMed)
    Show all 5 references for ABIN954731

  2. Human Polyclonal SRGN Primary Antibody for IHC, IHC (p) - ABIN4355974 : Chang, Chan, Braun, Green, OBrien, Chait, Day, Wight: Monocyte-to-macrophage differentiation: synthesis and secretion of a complex extracellular matrix. in The Journal of biological chemistry 2012 (PubMed)
    Show all 4 references for ABIN4355974

  3. Human Monoclonal SRGN Primary Antibody for ELISA, WB - ABIN519156 : Li, Ong, Cao, Xiang, Shao, Ooi, Peng, Lu, Zhang, Petillo, Qin, Bao, Zheng, Chia, Iyer, Kang, Zeng, Soo, Trent, Teh, Qian: Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis. in Cancer research 2011 (PubMed)
    Show all 3 references for ABIN519156

More Antibodies against serglycin Interaction Partners

Human serglycin (SRGN) interaction partners

  1. SRGN expression is significantly upregulated in human masticatory mucosa during wound healing

  2. Patients with NPC (show NPC1 Antibodies) with tumors showing strong tumor intensity and low infiltrated percentage of tumor-infiltrated lymphocytes with serglycin may be at high risk for distant metastases.

  3. The elevated levels of serglycin in aggressive cancer and stromal cells may suggest a key role for serglycin in disease progression

  4. These results suggest functions for serglycin in endothelial cells trough interactions with partner molecules, in biological processes with relevance for diabetic complications, cardiovascular disease and cancer development.

  5. These results suggest that different signaling pathways are involved in regulating secretion of serglycin and partner molecules in activated endothelial cells.

  6. The reduced expression of SRGN was accompanied by elevated levels of E-cadherin (show CDH1 Antibodies).

  7. These studies provide direct evidence for a critical role for serglycin in MM pathogenesis and show that targeting serglycin may provide a novel therapeutic approach for MM.

  8. These results suggest that human epicardial adipose tissue (EAT) has strong inflammatory properties in patients with coronary artery disease and provide novel evidence that serglycin is an adipocytokine highly expressed in EAT.

  9. Cell-surface SRGN promotes the adhesion of myeloma cells to collagen type I.

  10. This review covers recent studies on the involvement of serglycin in various pathological conditions, as well as its roles in immunity, hemostasis, cell growth, apoptosis, and reproduction.

Mouse (Murine) serglycin (SRGN) interaction partners

  1. serglycin deficient mice exhibited elevated concentrations of serum LDL after feeding high-fat diet for 20 weeks.

  2. serglycin plays a critical role in the maturation of dense-core cytotoxic granules in cytotoxic lymphocytes and the trafficking and storage of perforin (show PRF1 Antibodies) and granzyme B (show Gzmb Antibodies), whereas granzyme A (show GZMA Antibodies) is unaffected

  3. Wild-type mast cells efficiently degraded exogenous or endogenously produced IL-13 (show IL13 Antibodies) upon degranulation,whereas serglycin -/- mast cells completely lacked this ability.

  4. Dopamine storage increased during mast cell maturation from bone marrow precursors, and was dependent on the presence of serglycin.

  5. Cells lacking mouse mast cell protease 6 (show TPSB2 Antibodies) exhibited similar defects in apoptosis as observed in serglycin(-/-) cells, indicating that the pro-apoptotic function of serglycin is due to downstream effects of proteases that are complex-bound to serglycin

  6. The PRG-1 (show PTGR1 Antibodies) transcription is initiated at multiple transcription start site and no influence on expression in vivo by Nex1 (show NEUROD6 Antibodies) deficiency.

  7. serglycin proteoglycan as a novel player in mast cell apoptosis.

  8. serglycin proteoglycan is dispensable for normal secretion and activity of mast cell proteases in response to peritoneal infection with T. gondii.

  9. SG proteoglycan (show Vcan Antibodies) has a key role in mast cell function

  10. serglycin is the major proteoglycan (show Vcan Antibodies) secreted by peritoneal macrophages and the macrophage serglycin may have a role in regulating secretion of tumor necrosis factor-alpha (show TNF Antibodies)

serglycin (SRGN) Antigen Profile

Protein Summary

This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene.

Gene names and symbols associated with anti-serglycin (SRGN) Antibodies

  • serglycin (SRGN) antibody
  • serglycin (Srgn) antibody
  • Pgsg antibody
  • PPG antibody
  • Prg antibody
  • Prg1 antibody
  • Sgc antibody

Protein level used designations for anti-serglycin (SRGN) Antibodies

hematopoetic proteoglycan core peptide , hematopoetic proteoglycan core protein , hematopoietic proteoglycan core protein , p.PG , platelet proteoglycan core protein , proteoglycan 1, secretory granule , proteoglycan protein core for mast cell secretory granule , secretory granule proteoglycan core peptide , secretory granule proteoglycan core protein , serglycin proteoglycan , gp600 , mastocytoma proteoglycan core protein , proteoglycan, secretory granule , PG19 core protein , chondroitin sulfate proteoglycan core protein , cytolytic granule proteoglycan core protein , proteoglycan 10K core protein , proteoglycan peptide core protein

5552 Homo sapiens
19073 Mus musculus
56782 Rattus norvegicus
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