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crystal structures of human AT2R bound to an AT2R-selective ligand and to an AT1R (show AGTR1 Proteins)/AT2R dual ligand, capturing the receptor in an active-like conformation
Suggest a gender-specific association between the AT2R -1332 A/G polymorphism and the occurrence of carotid plaque and the history of cerebrovascular insult in advanced carotid atherosclerosis.
peripheral and central arterial pressures and pulse wave augmentation indexes (AIx(P), AIx(C1), AIx(C2)), pulse wave velocity (PWV), daily urinary sodium excretion were measured and did genetic studies of AGTR1 (show AGTR1 Proteins) A1166C and AGTR2 G1675A polymorphisms.
Significant overrepresentation of AT2R-1332 AA genotype in female multiple sclerosis patients was found, compared to female controls.
These data suggest that AT2R inhibits ligand-induced AT1R signaling through the PKC-dependent pathway.
Ang II (show AGT Proteins)-induced upregulation of ATF3 (show ATF3 Proteins) and SUMO1 (show SUMO1 Proteins) in vitro and in vivo was blocked by Ang II (show AGT Proteins) type I receptor antagonist olmesartan. Moreover, Ang II (show AGT Proteins) induced ATF3 (show ATF3 Proteins) SUMOylation at lysine 42, which is SUMO1 (show SUMO1 Proteins) dependent
The A1166C polymorphism of AT1R (show AGTR1 Proteins), A1675G and C3123A polymorphisms of AT2R were analyzed. The A1675G polymorphism of AT2R might be associated with preeclampsia
Ten tagging single nucleotide polymorphisms on AGTR1 (show AGTR1 Proteins)/AGTR2 were genotyped for all subjects with primary aldosteronism and controls.
AT2R downregulates the expression of TGF-betaRII in human proximal tubule cells
Angiotensin II type 2 receptor is present in human semen and may be involved in the control of sperm motility and male fertility.
AT2R inhibits adipogenic differentiation in mesenchymal stem cells. Moreover, this inhibitory effect is associated with Wnt10b (show WNT10B Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
These results suggest that nerve growth factor-mediated neurite outgrowth is suppressed by AT2 receptor signaling via the nitric oxide-cyclic GMP (show NT5C2 Proteins)-PKG (show PRKG1 Proteins) pathway.
AT2R expressing neurons make GABAergic synapses onto AVP (show AVP Proteins) neurons that inhibit AVP (show AVP Proteins) neuronal activity and suppress baseline systemic AVP (show AVP Proteins) levels.
Further deletion/mutation analysis revealed that multiple transcription factor binding sites in the +286/+690 region within intron 2 coordinately regulate AT2R transcription. Importantly, +286/+690 enhancer activity was suppressed in CHF mouse skeletal muscle, suggesting that AT2R expression is suppressed in CHF via inhibition of AT2R intronic enhancer activity, leading to lowered muscle regeneration.
This study suggests that deletion of AT2R decreases the expression of the beneficial ACE2/Ang-(1-7)/MasR.
Hypercholesterolemia blunts the oxidative stress and inflammatory cell recruitment elicited by hypertension in venules through a mechanism that involves AT2 receptor activation.
These results suggest that in the absence of AT2R, wound healing rate is accelerated, but yielded worse skin quality.
Bone marrow-AT2 deficiency aggravates atherosclerosis, at least in part, by eliminating the anti-atherogenic properties of macrophages elicited by LXRbeta (show NR1H2 Proteins) activation.
the possible roles of AT2 receptor-mediated dopamine regulation in the pathogenesis of Binge eating disorder, was investigated.
AT2R signaling positively regulates myoblast differentiation and potentiates skeletal muscle regenerative potential.
AT1 (show AGTR1 Proteins) and AT2 receptors heterodimerize and are involved in the angiotensin II effect on SERCA (show ATP2A3 Proteins) in proximal kidney tubules.
AT2 receptors are positively coupled to the proliferative response of vascular smooth muscle cells to angiotensin II.
Glomerular eNOS (show NOS3 Proteins) gene expression was studied during postnatal maturation and AT1 receptor (show AGTRAP Proteins) inhibition.
Data suggest that AGTR2 (and angiotensin-converting enzyme (show ACE Proteins)) mRNA levels are transiently up-regulated in ovarian theca cells during preovulatory period.
data suggest that G alpha(i3), Shc (show SHC1 Proteins), Grb2 (show GRB2 Proteins), Ras, and Raf-1 (show RAF1 Proteins) link Src (show SRC Proteins) to activation of MAPK (show MAPK1 Proteins) and to the AT(2)-dependent increase in eNOS (show NOS3 Proteins) expression in PAECs
Abundance of AGTR2 mRNA in granulosa cells was higher in healthy compared with atretic follicles, whereas in theca cells, it did not change
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation.
angiotensin II type-2 receptor
, type-2 angiotensin II receptor
, AT2 receptor
, angiotensin II type 2 receptor
, angiotensin receptor 2
, angiotensin II receptor type 2
, angiotensin type II receptor
, Type-2 angiotensin II receptor
, angiotensin II subtype 2 receptor, AT2