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AT2R downregulates the expression of TGF-betaRII in human proximal tubule cells
Angiotensin II type 2 receptor is present in human semen and may be involved in the control of sperm motility and male fertility.
Ang-(1 (show ANGPT1 Proteins)-7) downregulated AT1R (show AGTR1 Proteins) mRNA, upregulated mRNA levels of Ang II (show AGT Proteins) type 2 receptor (AT2R) and Mas (show MAS1 Proteins) receptor (MasR) and p38-MAPK (show MAPK14 Proteins) phosphorylation and suppressed H22 cell-endothelial cell communication
ATGR2 activation enhances ACE2 (show ACE2 Proteins) expression and activity and prevents TNF-alpha (show TNF Proteins)-stimulated ICAM-1 (show ICAM1 Proteins) expression .
AT1 receptor expression was associated to enhance angiogenesis and cellular proliferation rate, but no relationship with AT2 was found
Our results support that the AGTR2 gene may contribute to the pathogenesis of UPJO and the genetic origin of CAKUT could vary according to phenotype expression
in colorectal cancer, AT2R expression showed an inverse correlation with tumor stage and liver metastasis
Suggest a key regulatory role of ATI and ATII in promoting cellular proliferation in infantile hemangioma, and establish a role for ACE (show ACE Proteins) and ATIIR2 in the proliferation of this tumour.
The AGTR2 gene C allele is associated with an increased proportion of slow-twitch muscle fibres.
Type 2 angiotensin II receptor (ATR2) expression was 3.5-fold higher in bronchoalveolar cells 1-6 h after lung with cardiopulmonary bypass transplantation.
AT2R signaling positively regulates myoblast differentiation and potentiates skeletal muscle regenerative potential.
The functional activities of AT2R is time-dependently modulated under hypoxia in the central nervous system in comparison with the adrenal glands.
AT2R expression may contribute to pregnancy-induced hypertension and thus represents a potential therapeutic target.
These data revealed an AT2 receptor-mediated mechanism regulating pancreatic endocrine cell development in vivo.
Data suggest that AT2 receptor affects postnatal cardiac growth possibly via reducing body weight gain and systemic blood pressure.
Data suggest that whether overexpression of angiotensin II type 2 receptor AT2R is beneficial or detrimental to the heart is largely dependent on expression levels.
The present study shows that the angiotensin system, especially that involving AT2R, may have an oxidative injury-potentiating effect via augmentation of the activity of NADPH oxidase (show NOX1 Proteins).
Direct stimulation of the angiotensin II type 2 receptor improves endothelial function and reduces atherosclerotic plaque progression.
blockade of the AT1 receptor (show AGTRAP Proteins) by azilsartan could enhance the activities of the ACE2 (show ACE2 Proteins)/Ang-(1 (show ANGPT1 Proteins)-7)/Mas (show MAS1 Proteins) axis and ACE2 (show ACE2 Proteins)/Ang-(1 (show ANGPT1 Proteins)-7)/AT2 receptor axis, thereby inhibiting neointimal formation.
The levels of AT-2 but not AT-1 receptor are modulated by the pro-fibrotic factor TGFB1 (show TGFB1 Proteins) in myoblasts and mouse skeletal muscle.
AT1 (show AGTR1 Proteins) and AT2 receptors heterodimerize and are involved in the angiotensin II effect on SERCA (show ATP2A3 Proteins) in proximal kidney tubules.
AT2 receptors are positively coupled to the proliferative response of vascular smooth muscle cells to angiotensin II.
Glomerular eNOS (show NOS3 Proteins) gene expression was studied during postnatal maturation and AT1 receptor (show AGTRAP Proteins) inhibition.
Data suggest that AGTR2 (and angiotensin-converting enzyme (show ACE Proteins)) mRNA levels are transiently up-regulated in ovarian theca cells during preovulatory period.
data suggest that G alpha(i3), Shc (show SHC1 Proteins), Grb2 (show GRB2 Proteins), Ras, and Raf-1 (show RAF1 Proteins) link Src (show SRC Proteins) to activation of MAPK (show MAPK1 Proteins) and to the AT(2)-dependent increase in eNOS (show NOS3 Proteins) expression in PAECs
Abundance of AGTR2 mRNA in granulosa cells was higher in healthy compared with atretic follicles, whereas in theca cells, it did not change
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation.
angiotensin II type-2 receptor
, type-2 angiotensin II receptor
, AT2 receptor
, angiotensin II type 2 receptor
, angiotensin receptor 2
, angiotensin II receptor type 2
, angiotensin type II receptor
, Type-2 angiotensin II receptor
, angiotensin II subtype 2 receptor, AT2