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peripheral and central arterial pressures and pulse wave augmentation indexes (AIx(P), AIx(C1), AIx(C2)), pulse wave velocity (PWV), daily urinary sodium excretion were measured and did genetic studies of AGTR1 (show AGTR1 Proteins) A1166C and AGTR2 G1675A polymorphisms.
Significant overrepresentation of AT2R-1332 AA genotype in female multiple sclerosis patients was found, compared to female controls.
These data suggest that AT2R inhibits ligand-induced AT1R signaling through the PKC-dependent pathway.
Ang II (show AGT Proteins)-induced upregulation of ATF3 (show ATF3 Proteins) and SUMO1 (show SUMO1 Proteins) in vitro and in vivo was blocked by Ang II (show AGT Proteins) type I receptor antagonist olmesartan. Moreover, Ang II (show AGT Proteins) induced ATF3 (show ATF3 Proteins) SUMOylation at lysine 42, which is SUMO1 (show SUMO1 Proteins) dependent
The A1166C polymorphism of AT1R (show AGTR1 Proteins), A1675G and C3123A polymorphisms of AT2R were analyzed. The A1675G polymorphism of AT2R might be associated with preeclampsia
Ten tagging single nucleotide polymorphisms on AGTR1 (show AGTR1 Proteins)/AGTR2 were genotyped for all subjects with primary aldosteronism and controls.
AT2R downregulates the expression of TGF-betaRII in human proximal tubule cells
Angiotensin II type 2 receptor is present in human semen and may be involved in the control of sperm motility and male fertility.
Ang-(1 (show ANGPT1 Proteins)-7) downregulated AT1R (show AGTR1 Proteins) mRNA, upregulated mRNA levels of Ang II (show AGT Proteins) type 2 receptor (AT2R) and Mas (show MAS1 Proteins) receptor (MasR) and p38-MAPK (show MAPK14 Proteins) phosphorylation and suppressed H22 cell-endothelial cell communication
ATGR2 activation enhances ACE2 (show ACE2 Proteins) expression and activity and prevents TNF-alpha (show TNF Proteins)-stimulated ICAM-1 (show ICAM1 Proteins) expression .
Hypercholesterolemia blunts the oxidative stress and inflammatory cell recruitment elicited by hypertension in venules through a mechanism that involves AT2 receptor activation.
These results suggest that in the absence of AT2R, wound healing rate is accelerated, but yielded worse skin quality.
Bone marrow-AT2 deficiency aggravates atherosclerosis, at least in part, by eliminating the anti-atherogenic properties of macrophages elicited by LXRbeta (show NR1H2 Proteins) activation.
the possible roles of AT2 receptor-mediated dopamine regulation in the pathogenesis of Binge eating disorder, was investigated.
AT2R signaling positively regulates myoblast differentiation and potentiates skeletal muscle regenerative potential.
The functional activities of AT2R is time-dependently modulated under hypoxia in the central nervous system in comparison with the adrenal glands.
AT2R expression may contribute to pregnancy-induced hypertension and thus represents a potential therapeutic target.
These data revealed an AT2 receptor-mediated mechanism regulating pancreatic endocrine cell development in vivo.
Data suggest that AT2 receptor affects postnatal cardiac growth possibly via reducing body weight gain and systemic blood pressure.
Data suggest that whether overexpression of angiotensin II type 2 receptor AT2R is beneficial or detrimental to the heart is largely dependent on expression levels.
AT1 (show AGTR1 Proteins) and AT2 receptors heterodimerize and are involved in the angiotensin II effect on SERCA (show ATP2A3 Proteins) in proximal kidney tubules.
AT2 receptors are positively coupled to the proliferative response of vascular smooth muscle cells to angiotensin II.
Glomerular eNOS (show NOS3 Proteins) gene expression was studied during postnatal maturation and AT1 receptor (show AGTRAP Proteins) inhibition.
Data suggest that AGTR2 (and angiotensin-converting enzyme (show ACE Proteins)) mRNA levels are transiently up-regulated in ovarian theca cells during preovulatory period.
data suggest that G alpha(i3), Shc (show SHC1 Proteins), Grb2 (show GRB2 Proteins), Ras, and Raf-1 (show RAF1 Proteins) link Src (show SRC Proteins) to activation of MAPK (show MAPK1 Proteins) and to the AT(2)-dependent increase in eNOS (show NOS3 Proteins) expression in PAECs
Abundance of AGTR2 mRNA in granulosa cells was higher in healthy compared with atretic follicles, whereas in theca cells, it did not change
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation.
angiotensin II type-2 receptor
, type-2 angiotensin II receptor
, AT2 receptor
, angiotensin II type 2 receptor
, angiotensin receptor 2
, angiotensin II receptor type 2
, angiotensin type II receptor
, Type-2 angiotensin II receptor
, angiotensin II subtype 2 receptor, AT2