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These results indicate that KOR (show OPRK1 Proteins) can form a heterodimer with B2R and this leads to increased protein kinase A activity by the CREB (show CREB1 Proteins) signaling pathway, leading to a significant increase in cell proliferation.
Study demonstrated the ability of long-chain polyunsaturated fatty acids to act as agonist to the B2R at nanomolar concentrations and to induce receptor conformational changes.
Data suggest that N-myc (and STAT) interactor (NMI (show NMI Proteins)) could improve its downstream target bradykinin B2 receptor (BDKRB2) expression to induce extracellular signal-regulated kinases (ERK) 1 (show MAPK3 Proteins)/2 activation, and thereby further evoke malignant progression of hepatocellular carcinoma (HCC (show FAM126A Proteins)).
Data show that mRNA and protein of bradykinin type 2 receptors, but not bradykinin type 1 receptors, were abundant in cultured c-Kit+ progenitor cells.
BDKRB2 +9/-9 bp polymorphisms affected the gene expression and nitric oxide production, which were associated with radiographic severity of osteoarthritis, suggesting that the BDKRB2 +9/ -9 bp polymorphisms may act as a genetic modulator of osteoarthritis, and play an essential role in inflammatory process in osteoarthritis.
authors found significant interactions among PRKCA (show PKCa Proteins), NOS3 (show NANOS3 Proteins) and BDKRB2 genotypes associated with enalapril responses.
Bronchial B2R expression is constitutively elevated in allergic asthma and is further increased after allergen exposure together with NF-kB expression.
Report the presence of nuclear B2R in the utero-placental unit and reduced abundance of nuclear B2R in extravillous trophoblast in preeclampsia.
Data provide evidence that the BDKRB2 +9/-9 polymorphisms influence pro-inflammatory cytokine levels in knee osteoarthritis by altering TLR-2 expression.
These results suggest that the response to long-term exercise training could be modulated by the BDKRB2 gene -9/+9 polymorphism in male athletes. In well-trained swimmers, BDKRB2 gene variation was not found to be an independent determinant of swimming performance.
B2R signaling promotes aortic rupture within a ApoE (show APOE Proteins)-eficient mouse model associated with the ability to stimulate inflammatory phenotypes of neutrophils and vascular smooth muscle cells.
B2R activation occurs in the diabetic skin and delays wound healing. B2R blockade improves skin wound healing in diabetic mice and is a potential therapeutic approach to diabetic ulcers.
a novel pathway by which C5aR (show C5AR1 Proteins)/B2R cross-talk couples transendothelial leakage of plasma proteins to the cytokine circuitry that coordinates antiparasite immunity.
investigated if expression of B1 and B2 kinin receptors can be affected by IL-4 (show IL4 Proteins) and IL-13 (show IL13 Proteins); data show, for the first time, that IL-4 (show IL4 Proteins) and IL-13 (show IL13 Proteins) decrease kinin receptors in a STAT6 (show STAT6 Proteins)-dependent mechanism
Data suggest that nicotine impairs mucosa-dependent Bdkrb2 (bradykinin B2 receptor) mediated trachea relaxation; nicotine also down-regulates tracheal expression of COX2/Ptgs2 (cyclooxygenase 2 (show PTGS2 Proteins)) and mPGES-1 (show PTGES Proteins) (microsomal prostaglandin E2 synthase-1).
Data suggest that expression of Bdkrb2 is up-regulated in adrenal medulla as the result of immobilization stress; data from CRH (corticotropin-releasing hormone (show CRH Proteins)) knockout mice suggest this up-regulation requires catecholaminergic glucocorticoids.
B1R (show BDKRB1 Proteins) and B2R receptors exert a critical role in the establishment of persistent hypersensitivity observed in an experimental autoimmune encephalomyelitis model
Data indicate that Bdkrb2(-/-) mice have elevated plasma angiotensin-(1-7) and messenger RNA and protein for its receptor Mas (show MAS1 Proteins).
Null mutations at the p66 (show POLD3 Proteins) and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney in mice.
These findings suggest that activation of the bradykinin/B2R pathway contributes to development of host resistance to visceral leishmaniasis.
A persistent B2R-beta2AR (show ADRB2 Proteins) heterodimer was confirmed in bradykinin-stimulated and non-stimulated left ventricular myocardium. BK transactivation of beta2AR (show ADRB2 Proteins) enhanced beta2AR (show ADRB2 Proteins)-mediated release of tPA (show PLAT Proteins).
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein.
B2 bradykinin receptor
, BK-2 receptor
, bradykinin B2 receptor
, ornithokinin receptor
, bradykinin receptor B2
, B2 bradykinin receptor-like
, b2 bradykinin receptor-like
, bradykinin receptor, beta 2
, kinin B2