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These results suggest that the response to long-term exercise training could be modulated by the BDKRB2 gene -9/+9 polymorphism in male athletes. In well-trained swimmers, BDKRB2 gene variation was not found to be an independent determinant of swimming performance.
Significant association between the -58T/C polymorphism and the increased risk of Hypertension was found in Northern Han Chinese population.
Bradykinin inhibits oxidative stress-induced (show SQSTM1 Proteins) senescence of endothelial progenitor cells through the B2R/AKT (show AKT1 Proteins)/RB and B2R/EGFR (show EGFR Proteins)/RB signal pathways.
Bradykinin receptor B2 (B2R) genetic variation may affect thirst because of effects bradykinin activity.
These results indicate that B2R couples with P2Y2R and that these G-protein-coupled receptors act together to fine-tune cellular responsiveness.
The nasal mucosa specimens from chronic rhinosinusitis patients expressed relatively higher B2R and slightly higher kininogen (KNG (show KNG1 Proteins))/BK and B1R (show BDKRB1 Proteins).
BKR1 (show BDKRB1 Proteins) and BKR2 gene expression on peripheral monocytes is upregulated in essential hypertension
Bradykinin receptor B2-VNTR length polymorphism was not associated with angina pectoris and myocardial infarction in Russian men.
Bradykinin increases IL-6 (show IL6 Proteins) production via B2R and the ERK (show EPHB2 Proteins) pathway, thereby contributing to the invasion and migration of colorectal cancer cells.
We propose that heterodimerization of bradykinin B2 receptor with lamin C is essential to nuclear localization of bradykinin B2 receptor and plays an important role in cell signaling and function.
B2R activation occurs in the diabetic skin and delays wound healing. B2R blockade improves skin wound healing in diabetic mice and is a potential therapeutic approach to diabetic ulcers.
a novel pathway by which C5aR (show C5AR1 Proteins)/B2R cross-talk couples transendothelial leakage of plasma proteins to the cytokine circuitry that coordinates antiparasite immunity.
investigated if expression of B1 and B2 kinin receptors can be affected by IL-4 (show IL4 Proteins) and IL-13 (show IL13 Proteins); data show, for the first time, that IL-4 (show IL4 Proteins) and IL-13 (show IL13 Proteins) decrease kinin receptors in a STAT6 (show STAT6 Proteins)-dependent mechanism
Data suggest that nicotine impairs mucosa-dependent Bdkrb2 (bradykinin B2 receptor) mediated trachea relaxation; nicotine also down-regulates tracheal expression of COX2/Ptgs2 (cyclooxygenase 2 (show PTGS2 Proteins)) and mPGES-1 (show PTGES Proteins) (microsomal prostaglandin E2 synthase-1).
Data suggest that expression of Bdkrb2 is up-regulated in adrenal medulla as the result of immobilization stress; data from CRH (corticotropin-releasing hormone (show CRH Proteins)) knockout mice suggest this up-regulation requires catecholaminergic glucocorticoids.
B1R (show BDKRB1 Proteins) and B2R receptors exert a critical role in the establishment of persistent hypersensitivity observed in an experimental autoimmune encephalomyelitis model
Data indicate that Bdkrb2(-/-) mice have elevated plasma angiotensin-(1-7) and messenger RNA and protein for its receptor Mas (show MAS1 Proteins).
Null mutations at the p66 (show POLD3 Proteins) and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney in mice.
These findings suggest that activation of the bradykinin/B2R pathway contributes to development of host resistance to visceral leishmaniasis.
Data indicate that under normal sodium intake, epithelial Na(+) channel (ENaC (show SCNN1A Proteins)) open probability (P(o)) was modestly elevated in bradykinin receptors B1R (show BDKRB1 Proteins), B2R(-/-) mice.
A persistent B2R-beta2AR (show ADRB2 Proteins) heterodimer was confirmed in bradykinin-stimulated and non-stimulated left ventricular myocardium. BK transactivation of beta2AR (show ADRB2 Proteins) enhanced beta2AR (show ADRB2 Proteins)-mediated release of tPA (show PLAT Proteins).
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein.
B2 bradykinin receptor
, BK-2 receptor
, bradykinin B2 receptor
, ornithokinin receptor
, bradykinin receptor B2
, B2 bradykinin receptor-like
, b2 bradykinin receptor-like
, bradykinin receptor, beta 2
, kinin B2