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Browse our CMA1 Proteins (CMA1)

Full name:
Chymase 1, Mast Cell Proteins (CMA1)
On are 16 Chymase 1, Mast Cell (CMA1) Proteins from 6 different suppliers available. Additionally we are shipping CMA1 Antibodies (91) and CMA1 Kits (30) and many more products for this protein. A total of 144 CMA1 products are currently listed.
chymase, CMA1, CYH, Mcp-5, MCP3P, Mcp5, Mcpt5, MCT1, MMCP-5
list all proteins Gene Name GeneID UniProt
CMA1 17228 P21844
CMA1 1215 P23946
CMA1 25627 P50339

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CMA1 Proteins (CMA1) by Origin

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Mouse (Murine) Chymase 1, Mast Cell (CMA1) interaction partners

  1. Data indicate that a second-degree burn injury can initiate an immediate novel zonal degranulation of mast cell throughout all skin layers and a disruption of the epidermal tight junctions dependent on the nonredundant presence of mMCP4 and mMCP5.

  2. mast cell/chymase-mediated intestinal epithelial barrier function is mediated by proteinase-activated receptor 2 (show F2RL1 Proteins)/MMP (show MMP2 Proteins)-2 (show MMP2 Proteins)-dependent

  3. mMCP-4-deficient mice but not to mMCP-5-deficient mice revealing nonredundant actions for these two MC proteases in a model of innate inflammatory injury with remodeling.

  4. mast cell mMCP-4, -5, and -6 (chymase and tryptase (show TPSAB1 Proteins)) participate in the acute inflammation and remodeling process of viral myocarditis.

  5. The prominent mast cell secretory granule protease MCP-5 is essential for the occurrence of irreversible ischemia-reperfusion injury of skeletal muscle.

  6. mast cell chymase activates ERK (show EPHB2 Proteins) and p38 (show CRK Proteins) probably through G-protein-coupled receptor (show GPR34 Proteins), and the ERK (show EPHB2 Proteins) but not p38 (show CRK Proteins) cascade may have a crucial role in chymase-induced migration of eosinophils

  7. chymase rapidly cleaves recombinant pro-IL-18 (show IL18 Proteins) at 56-phenylalanine and produces a biologically active IL-18 (show IL18 Proteins) fragment that is smaller than any other reported IL-18 (show IL18 Proteins)-derived species

  8. Just after stopping the angiotensin II infusion, aortic ACE (show ACE Proteins) and chymase activities were significantly increased, and were involved in the progression of aortic abdominal aneurysms

  9. experimental abdominal aortic aneurysm in wild-type mice or those deficient in the chymase ortholog mouse mMCP-4 or deficient in mMCP-5 (Mcpt4(-/-), Mcpt5(-/-)), Mcpt4(-/-) but not Mcpt5(-/-) had reduced abdominal aortic aneurysm formation

Human Chymase 1, Mast Cell (CMA1) interaction partners

  1. activation of endothelial CLP (show CALML3 Proteins)/chymase may directly relate to the increased inflammatory phenotypic changes in the vascular system in women with preeclampsia

  2. Placenta-derived chymotrypsin-like protease contributes to the altered endothelial barrier function in preeclampsia.

  3. Our data demonstrated that mast cell chymase plays an important role in keloid formation through TGF-beta1 (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling pathway.

  4. These data suggest a possible contribution of human chymase activation to LPS (show IRF6 Proteins)-induced mortality

  5. we present data indicating that MC tryptase (show TPSAB1 Proteins) and chymase contribute to the development of OSF (show OSTF1 Proteins) and malignant transformation of the overlying epithelium.

  6. The polymorphisms and haplotypes of the CMA1 locus are associated with cardiac hypertrophy in male patients with symptomatic aortic stenosis.

  7. CMA1 gene single nucleotide polymorphisms is associated with essential hypertension.

  8. Significant association between the AG genotype of CMA1 A polymorphism and Angina Pectoris and Ventricular Extrasystoles was observed.

  9. demonstrate the generation of Pso (show PIPOX Proteins) p27 (show PAK2 Proteins) from SCCA1 with extracts from psoriatic scale and even more remarkably, the generation of Pso (show PIPOX Proteins) p27 (show PAK2 Proteins) from SCCA1 in the presence of mast cell associated chymase

  10. The present results indicated PRCP rs7104980 can be considered as a marker for EH and Hap3 GAGCACTAACA (PRCP) and Hap16 TTTA (CMA1) might be associated with essential hypertension in Chinese Han population.

CMA1 Protein Profile

Protein Summary

This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases.

Alternative names and synonyms associated with CMA1

  • chymase 1, mast cell (CMA1)
  • chymase 1, mast cell (Cma1)
  • chymase protein
  • CMA1 protein
  • CYH protein
  • Mcp-5 protein
  • MCP3P protein
  • Mcp5 protein
  • Mcpt5 protein
  • MCT1 protein
  • MMCP-5 protein

Protein level used designations for Chymase 1, Mast Cell Proteins (CMA1)

chymase 1, mast cell , alpha-chymase , chymase , mast cell chymase 1 , mast cell protease 5 , mast cell protease I , chymase 1 preproprotein transcript E , chymase 1 preproprotein transcript I , chymase, heart , chymase, mast cell , mast cell protease 3 , mast cell protease III , rMCP-3 , rMCP-5 , rMCP-III , mast cell chymase , serine protease

540321 Bos taurus
745533 Pan troglodytes
100139881 Bos taurus
17228 Mus musculus
1215 Homo sapiens
25627 Rattus norvegicus
100135503 Cavia porcellus
490628 Canis lupus familiaris
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