CMA1 Products
(Chymase 1, Mast Cell (CMA1))
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This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq, Jul 2008].
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Featured CMA1 Categories
CMA1 Antibodies
High quality antibodies with extensive validation data.
CMA1 ELISA Kits
Reliable ELISA kits for a wide range of species.
CMA1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CMA1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (4)
Cat. No.
ABIN768626
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
IHC, IF
Validations
- (3)
Cat. No.
ABIN7073506
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC
Validations
- (2)
Cat. No.
ABIN6263136
Quantity
100 μL
Datasheet
Datasheet
Recommended CMA1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (1)
Cat. No.
ABIN6954794
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6954795
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6954796
Quantity
96 tests
Datasheet
Datasheet
Recommended CMA1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3077902
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3133314
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Dog
Source
Yeast
Validations
- (2)
Cat. No.
ABIN7478926
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our CMA1 products
: "Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury." in: Science advances, Vol. 6, Issue 12, pp. eaay6314, (2020) (PubMed).: "Oral sensitization to whey proteins induces age- and sex-dependent behavioral abnormality and neuroinflammatory responses in a mouse model of food allergy: a potential role of mast cells." in: Journal of neuroinflammation, Vol. 15, Issue 1, pp. 120, (2019) (PubMed).
: "A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis. ..." in: Nature communications, Vol. 8, pp. 14017, (2017) (PubMed).
: "Mast Cell-Derived Tryptase in Geographic Atrophy." in: Investigative ophthalmology & visual science, Vol. 58, Issue 13, pp. 5887-5896, (2017) (PubMed).
: "THE AUTOCRINE ROLE OF TRYPTASE IN PRESSURE OVERLOAD-INDUCED MAST CELL ACTIVATION, CHYMASE RELEASE AND CARDIAC FIBROSIS." in: IJC metabolic & endocrine, Vol. 10, pp. 16-23, (2016) (PubMed).
: "Role of Chymase in the Development of Liver Cirrhosis and Its Complications: Experimental and Human Data." in: PLoS ONE, Vol. 11, Issue 9, pp. e0162644, (2016) (PubMed).
: "GPR30 decreases cardiac chymase/angiotensin II by inhibiting local mast cell number." in: Biochemical and biophysical research communications, Vol. 459, Issue 1, pp. 131-6, (2015) (PubMed).
: "Peritoneal mast cell degranulation and gastrointestinal recovery in patients undergoing colorectal surgery." in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, Vol. 27, Issue 6, pp. 764-74, (2015) (PubMed).
: "Chymase mediates injury and mitochondrial damage in cardiomyocytes during acute ischemia/reperfusion in the dog." in: PLoS ONE, Vol. 9, Issue 4, pp. e94732, (2014) (PubMed).
: "Mediators of mast cells in bullous pemphigoid and dermatitis herpetiformis." in: Mediators of inflammation, Vol. 2014, pp. 936545, (2014) (PubMed).
Synonyms and alternative names related to CMA1
chymase 1 (CMA1), chymase 1 (Cma1), chymase 1, mast cell (CMA1), chymase 1, mast cell (Cma1), chymase-like (LOC100008644), chymase, Chymase, CMA1, CYH, Mcp-5, MCP3P, Mcp5, Mcpt5, MCT1, MMCP-5Protein level used designations for CMA1
- alpha-chymase
- chymase
- chymase 1 preproprotein transcript E
- chymase 1 preproprotein transcript I
- chymase, heart
- chymase, mast cell
- mast cell protease I
- mast cell chymase
- serine protease
- SMCP-2
- mast cell protease 2
- mast cell chymase 1
- mast cell protease 5
- mast cell protease 3
- mast cell protease III
- rMCP-3
- rMCP-5
- rMCP-III
- chymase 1, mast cell
- Alpha-chymase
- LOW QUALITY PROTEIN: chymase
- chymase like protein
- preprochymase
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