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Here, we review the role and effects of ACE2 (show ACE2 ELISA Kits), ACE2 (show ACE2 ELISA Kits) activators, Ang-(1 (show ANGPT1 ELISA Kits)-7) and synthetic Mas receptor agonists in the control of inflammation and fibrosis in cardiovascular and renal diseases and as counter-regulators of the ACE (show ACE ELISA Kits)-Ang II (show AGT ELISA Kits)-AT1 (show AGTR1 ELISA Kits) axis.
Downregulation of ACE2 (show ACE2 ELISA Kits)/Ang-(1 (show ANGPT1 ELISA Kits)-7)/Mas axis stimulates breast cancer metastasis through the activation of store-operated calcium entry and PAK1 (show PAK1 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits)/Snail1 (show SNAI1 ELISA Kits) pathways.
These results indicated that angiotensin-(1-7)/ACE2/Mas axis may reduce liver lipid accumulation partly by regulating lipid-metabolizing genes through ATP/P2 receptor/CaM signaling pathway.
Ang-(1 (show ANGPT1 ELISA Kits)-7) downregulated AT1R (show AGTR1 ELISA Kits) mRNA, upregulated mRNA levels of Ang II (show AGT ELISA Kits) type 2 receptor (AT2R (show AGTR2 ELISA Kits)) and Mas receptor (MasR) and p38-MAPK (show MAPK14 ELISA Kits) phosphorylation and suppressed H22 cell-endothelial cell communication
MAS1 might act as an inhibitory regulator of breast cancer.
Data show that MAS receptor exhibited constitutive activity that was inhibited by the non-peptide inverse agonist.
Data suggest that angiotensin converting enzyme 2 (show ACE2 ELISA Kits)/angiotensin II-(1-7)/MAS1 axis regulates leukocyte recruitment/activation, cell proliferation, and inflammation/fibrosis; main topic here is kidney/inflammatory renal disease. [REVIEW]
Up-regulation of the ACE2 (show ACE2 ELISA Kits)/Ang-(1 (show ANGPT1 ELISA Kits)-7)/Mas axis protected against pulmonary fibrosis by inhibiting the MAPK (show MAPK1 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits) pathway.
A proximal promoter construct for the MAS gene was repressed by the SOX (show PIPOX ELISA Kits) [SRY (show SRY ELISA Kits) (sex-determining region on the Y chromosome) box] proteins SRY (show SRY ELISA Kits), SOX2 (show SOX2 ELISA Kits), SOX3 (show SOX3 ELISA Kits) and SOX14 (show SOX14 ELISA Kits), of which SRY (show SRY ELISA Kits) is known to interact with the KRAB domain.
Mas appears to be a critical component required for NO-mediated vasodilatation induced by renin angiotensin system-dependent and RAS-independent agonists and therefore arises as a key pharmacological target to modulate endothelial function
This study aimed to define whether sex chromosome complement (SCC (show CYP11A1 ELISA Kits)) may differentially modulate sex differences in relative gene expression of basal Agtr1a (show AGTR1 ELISA Kits), Agtr2 (show AGTR2 ELISA Kits), and Mas1 receptors at fore/hindbrain nuclei and at medulla/cortical kidney.
MasR deficiency abolishes protection of female mice from obesity-induced hypertension
Results suggest that angiotensin converting enzyme 2 (show ACE2 ELISA Kits) may reduce anxiety-like behavior by activating central Mas receptor that facilitate GABA release onto pyramidal neurons within the basolateral amygdala.
impairment of the ANG-(1 (show ANGPT1 ELISA Kits)-7)/Mas receptor pathway may lead to worsening of the pathophysiological changes of asthma.
The data indicate a significant function of Ang-(1 (show ANGPT1 ELISA Kits)-7) in the regulation of insulin (show INS ELISA Kits) secretion from mouse islets in vitro and in vivo, mainly, but not exclusively, by Mas-dependent signaling, modulating the accessory pathway of insulin (show INS ELISA Kits) secretion via increase in cAMP.
This study suggests that deletion of AT2R decreases the expression of the beneficial ACE2/Ang-(1-7)/MasR.
Ang-(1 (show ANGPT1 ELISA Kits)-7)/Mas axis seems more important in autonomic modulation of arterial pressure than heart rate.
Mas receptor mediates cardioprotection of angiotensin-(1-7) against Ang II (show AGT ELISA Kits)-induced cardiomyocyte autophagy and cardiac remodelling through inhibition of oxidative stress.
MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular ACE2 (show ACE2 ELISA Kits)-angiotensin-(1-7)-MAS axis functionality
Mas receptor deficiency results in exacerbated inflammation in LPS (show TLR4 ELISA Kits)-challenged mice, which suggest a potential role for the Mas receptor as a regulator of systemic and brain inflammatory response induced by LPS (show TLR4 ELISA Kits).
The objective of this study was to characterize the profiles of Ang-(1-7), MAS receptor, ACE(2), NEP and PEP during the ovulatory process in cattle.
oncogene\; may be involved in function or development of neural tissues
, MAS proto-oncogene
, angiotensin-(1-7) receptor
, MAS1 oncogene