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Data demonstrate that there are distinct differences between the human mineralocorticoid receptor (MR) and the zebrafish MR despite considerable sequence and functional conservation.
The new frameshift mutation decreased the expression of MR, but not NR3C2 mRNA, and led to decreased MR function, with no dominant negative effect.
dysregulation of GR, MR, FKBP5 (show FKBP5 Proteins), and PTGES3 (show PTGES3 Proteins) in autistic spectrum disorder (ASD (show ARSD Proteins)) and suggest a possible role of inflammation in altered GR function in ASD (show ARSD Proteins).
hyperactive hypothalamo-pituitary-adrenocortical axis in overweight diabetic subjects may be associated with downregulation of 11beta-HSD1 (show HSD11B1 Proteins), MR, and GR in the brain.
Our current findings demonstrate that Arctigenin is an antagonist of MR and effectively decreases the Na/K-ATPase 1 (show ATP1A1 Proteins) gene expression. Our work provides a hint for the drug discovery against cardiovascular disease
Data show that both mineralcorticoid receptor (MR) and G-protein estrogen receptor (show ESR1 Proteins) (GPER) contribute to the proliferation and migration of breast and endothelial cancer cells by sodium-hydrogen exchanger 1 (show SLC9A1 Proteins) protein (NHE-1 (show SLC9A1 Proteins)) upon aldosterone exposure.
Data show that aldosterone via the mineralocorticoid receptor (MR) reduces microRNA miR (show MLXIP Proteins)-29b in vivo in murine aorta and in human primary and cultured vascular smooth muscle cells (VSMCs).
NR3C2 was found to be significantly associated with longitudinal systolic Blood Pressure change in a Han Chinese population.
Findings indicate that CS-3150 is a selective and highly potent mineralocorticoid receptor antagonist with long-lasting oral activity.
Among the class II HDACs, HDAC4 (show HDAC4 Proteins) interacted with both MR and HDAC3 (show HDAC3 Proteins) after aldosterone stimulation. The nuclear translocation of HDAC4 (show HDAC4 Proteins) was mediated by protein kinase A (PKA) and protein phosphatases (PP)
CBP (show CREBBP Proteins) and p300 (show EP300 Proteins) as lysine acetyltransferases responsible for the regulation of MR
Nr3c2 has a role in mouse skin development in a process that involves HSD11B1 (show HSD11B1 Proteins)/HSD11B2 (show HSD11B2 Proteins)
Inducible Knock-Down of the Mineralocorticoid Receptor in Mice Disturbs Regulation of the Renin (show REN Proteins)-Angiotensin-Aldosterone System and Attenuates Heart Failure Induced by Pressure Overload
Data indicate that endothelial cell mineralocorticoid receptor (MR) deficiency prevented Western diet (WD)-induced diastolic dysfunction, profibrotic, and progrowth signaling.
Cardiomyocyte mineralocorticoid receptor activation impairs acute cardiac functional recovery after ischemic insult.
a cooperative role of MR and cav-1 (show CAV1 Proteins) in regulating vascular contraction and NO-cGMP-mediated relaxation during low NO-high AngII-dependent cardiovascular injury
Upregulation of MR in mouse adipocytes led to increased weight and fat mass, insulin (show INS Proteins) resistance, and metabolic syndrome features without affecting blood pressure.
Data showed that the mRNA expression of glucocorticoid and mineralocorticoid receptors were significantly decreased in splenic macrophages by repeated social defeat. Epigenetic regulation, may play a role in the RSD-induced GC resistance.
Compared to sham-mice, the expression levels of hypothalamic MR, serum glucocorticoid-induced kinase 1 (a marker of MR activity) and AT1R (show AGTRAP Proteins) increased in pressure-overload-mice.
Data indicate that overexpression of constitutively active Rac1 activated mineralocorticoid receptor (MR).
AT1 (show SLC33A1 Proteins)-independent MR activation in the LV might be responsible for the pathogenesis of diabetic cardiomyopathy.
Effects of age, weaning and/or social isolation on the expression of genes regulating mineralocorticoid receptor.
analysis of the interdomain interaction in the mineralocorticoid receptor
This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
, nuclear receptor subfamily 3, group C, member 2
, nuclear receptor subfamily 3 group C member 2
, aldosterone receptor
, mineralocorticoid receptor 1
, mineralocorticoid receptor delta
, Mineralocorticoid receptor (aldosterone receptor)