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High expression of CD109 in brain tumor stem cells is involved in glioma progression.
The CD109 protein was up-regulated in hepatocellular carcinoma tissue compared with adjacent noncancerous tissue. CD109 shRNA knockdown delayed the G1-S phase transition, abrogated cell proliferation, and increased cell apoptosis. Furthermore, CD109 impaired TGF-beta (show TGFB1 ELISA Kits)/Smad (show SMAD1 ELISA Kits) signaling through control of p-smad2 (show SMAD2 ELISA Kits).
CD109 is a putative biomarker for identifying a high-risk group among DLBCL patients.
The most common HPA (show HPSE ELISA Kits) genotypes among Saudis were HPA-1 (show HPSE ELISA Kits) a + b- (75%), HPA-2 (show HPSE2 ELISA Kits) a + b- (62%), HPA-3 a + b- (51.5%), HPA (show HPSE ELISA Kits)-4 a + b- (99%), HPA-5 (show ITGA2 ELISA Kits) a + b- (76.5%), HPA (show HPSE ELISA Kits)-6 a + b- (100%) and HPA (show HPSE ELISA Kits)-15 a + b + (50%). The prevalent allele among the HPA (show HPSE ELISA Kits) systems was (a), except in the HPA (show HPSE ELISA Kits)-15 system where the (b) allele was found in 52% of the subjects.
Expression levels of CD109 was reduced significantly in psoriasis. Lower expression of CD109 and TGF-beta (show TGFB1 ELISA Kits) RI was highly correlated with higher expression of Smad7 (show SMAD7 ELISA Kits) and Ki67 (show MKI67 ELISA Kits), suggesting that CD109 may induce the pathogenesis of psoriasis through Smad7 (show SMAD7 ELISA Kits)-mediated degradation of TGF-beta (show TGFB1 ELISA Kits) RI.
sCD109 can bind TGF-beta (show TGFB1 ELISA Kits), inhibit TGF-beta (show TGFB1 ELISA Kits) binding to its receptors and decrease TGF-beta (show TGFB1 ELISA Kits) signalling and TGF-beta (show TGFB1 ELISA Kits)-induced cellular responses.
These findings indicate that CD109 is an exosomal protein and that the C-terminal region of CD109 is required for its presence in the exosome.
CD109 may be a potential pathology marker for gallbladder squamous cell/adenosquamous carcinomas.
CD109 is specifically expressed in endothelial cells of cutaneous cavernous haemangioma.
The results suggest that circulating endothelial cells express CD109 and represent a rare population of circulating tumor endothelial cells, that play a potentially useful prognostic role in patients with glioblastoma.
platelet and endothelial GARP (show LRRC32 ELISA Kits) are not important in hemostasis and thrombosis in mice
Small-scale in vivo screening identified several genes, including Cd109, that encode novel pro-metastatic factors. We uncovered signaling mediated by Janus kinases (Jaks) and the transcription factor Stat3 (show STAT3 ELISA Kits) as a critical, pharmacologically targetable effector of CD109-driven lung cancer metastasis
CD109 differentially regulates TGF-beta (show TGFB1 ELISA Kits)-induced ALK1 (show ACVRL1 ELISA Kits)-Smad1 (show SMAD1 ELISA Kits)/5 versus ALK5 (show TGFBR1 ELISA Kits)-Smad2 (show SMAD2 ELISA Kits)/3 pathways, leading to decreased extracellular matrix production in the skin; epidermal CD109 expression regulates dermal function through a paracrine mechanism
the GARP (show LRRC32 ELISA Kits)/LTGF-beta1 complex on Treg cells is a major source of TGF-beta1 (show TGFB1 ELISA Kits) needed for induction of pTreg cells during the process of oral tolerance.
GP96 (show HSP90B1 ELISA Kits) serves as an essential chaperone for the cell-surface protein (show CD28 ELISA Kits) glycoprotein A repetitions predominant (GARP (show LRRC32 ELISA Kits)), which is a docking receptor for latent membrane-associated TGF-beta (show TGFB1 ELISA Kits) (mLTGF-beta).
CD109 decreases extracellular matrix production and fibrotic responses during hypoxic wound healing
CD109 is present in serum as a soluble form, and suggest its potential as a novel tumor marker in patients with cancers that express CD109.
CD109 might be an important regulator of osteoclastogenesis.
findings demonstrate that CD109 overexpression in the epidermis reduces inflammation and granulation tissue area and improves collagen organization in vivo.
This gene encodes a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein is found on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signaling of transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene.
150 kDa TGF-beta-1-binding protein
, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7
, CD109 antigen
, Gov platelet alloantigens
, activated T-cell marker CD109
, platelet-specific Gov antigen
, CD109 molecule
, CD109 antigen-like
, GPI-anchored alpha 2 macroglobulin-related protein
, GPI-anchored alpha-2 macroglobulin-related protein