Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
knockdown of autophagy genes ATG5 or ATG7 (show ATG7 Proteins) resulted in reduced hematopoietic stem/progenitor cell frequencies in vitro as well as in vivo.
Data suggest that Atg5 expression level in dopaminergic (DA) neurons is decreased and autophagy flux is blocked in zebrafish MPTP model of Parkinson's disease (PD); gene therapy in embryo/larva resulting in human ATG5 overexpression reverses PD pathological features, rescues DA neurons, and restores autophagy flux in DA neurons; thus, ATG5 plays role in neuroprotection.
Genetic blockade of autophagy indicated an unexpected feedback loop whereby knocking down the autophagy factor ATG5 in Wnt5A (show WNT5A Proteins)(high) cells decreased Wnt5A (show WNT5A Proteins) and increased beta-catenin (show CTNNB1 Proteins).
Kaposi sarcoma-associated herpesvirus reduces CAST (calpastatin) and consequently decreases ATG5 expression in both THP-1 monocytoid cells and primary monocytes.
These results support ATG5 as a therapeutically relevant dose-dependent rheostat of melanoma progression.
above findings suggest that ATG5-ATG12 positively regulate anti-viral NF-kappaB and IRF3 signaling during FMDV infection, thereby limiting FMDV proliferation. FMDV has evolved mechanisms to counteract the antiviral function of ATG5-ATG12, via degradation of them by viral protein 3C(pro).
Confirm the association of rs548234/ATG5, rs2736340/BLK and rs10516487/BANK1 with systemic lupus erythematosus in Chinese Han and reinforced our hypothesis of their epistasis effect in regulating B-cell signaling in SLE.
Neither eosinophils nor neutrophils require ATG5-dependent autophagy for extracellular DNA trap formation.
ATG5 rs510432 gene polymorphism might be related to the occurrence of coal workers' pneumoconiosis in a Chinese population.
The expression levels of ATG5 and LC3 were associated with classification, histological grade, TNM stage and survival rate in renal carcinoma.
Studies show that the TOR signaling pathway and ATG5 and ATG7 (show ATG7 Proteins) are crucial for the regulation of cellular processes and can play various functions in different cell types in the brain.
Atg5, an essential component of the autophagy machinery, is required for the development of mature natural killer (NK) cells and group 1, 2, and 3 innate innate lymphoid cell.
Atg5-dependent autophagy contributes to the development of acute myeloid leukemia (show BCL11A Proteins) in an MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins)-driven mouse model.
Atg5 deficiency results in autophagy deficiency can lead to malignant cell transformation and resistance to Src (show SRC Proteins) family kinase inhibitors.
the results of this study suggest an important role of Atg5 and autophagy in maintaining the function of neutrophil extracellular traps formation in response to infection and in regulating neutrophil death
Results identify the beneficial role of hypothalamic ATF4/ATG5 axis in the regulation of energy expenditure, obesity, and obesity-related metabolic disorders.
this study shows that Atg5 knock-out mice have reduced disease severity in a mouse collagen induced arthritis model due to impaired T cell activation and proliferation
restoration of ATG5 in the brain is sufficient to rescue Atg5-null mice from neonatal lethality.
Treatment of aged mice and their derived macrophages with methyltransferase inhibitor (2)-epigallocatechin-3-gallate (EGCG) or specific DNA methyltransferase 2 (DNMT2 (show TRDMT1 Proteins)) siRNA restored the expression of Atg5 and LC3 (show MAP1LC3A Proteins) in vivo and in vitro.
miR-30b inhibited autophagy to alleviate hepatic ischemia-reperfusion injury by decreasing the Atg12-Atg5 conjugate.
Data suggest that atg5 expression level in dopaminergic (DA) neurons is decreased and autophagy flux is blocked in zebrafish MPTP model of Parkinson's disease (PD); gene therapy in embryo/larva resulting in human ATG5 overexpression reverses PD pathological features, rescues DA neurons, and restores autophagy flux in DA neurons; thus, ATG5 plays role in neuroprotection.
The important role of atg5 gene in zebrafish neurogenesis and organogenesis, is reported.
ATG5 defines a phagophore domain connected to the endoplasmic reticulum during autophagosome formation in plants.
Data indicate that the expression of MAP1LC3A (show MAP1LC3A Proteins), B and autophagy-associated genes (ATG5, mTOR (show FRAP1 Proteins), Beclin-1 (show BECN1 Proteins)) was increased in normal pigs, while decreased in miniature pigs.
Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity).
ATG5 autophagy related 5 homolog
, apoptosis specific protein
, apoptosis-specific protein
, autophagy protein 5
, autophagy-related 5
, autophagy 5-like protein
, APG5 autophagy 5-like
, potential preautophagosome nucleating protein Atg5