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Human ATG5 Protein expressed in Escherichia coli (E. coli) - ABIN667343
Mizushima, Noda, Yoshimori, Tanaka, Ishii, George, Klionsky, Ohsumi, Ohsumi: A protein conjugation system essential for autophagy. in Nature 1998
Show all 2 references for ABIN667343
The important role of atg5 gene in zebrafish neurogenesis and organogenesis, is reported.
ATG5 defines a phagophore domain connected to the endoplasmic reticulum during autophagosome formation in plants.
UA exerted antiatherosclerosis effects in quails and protected HUVECs from ox-LDL induced cytotoxicity, and the mechanism is associated with increased SIRT1 expression, decreased Atg5 acetylation on lysine residue, and increased autophagy.
Genetic polymorphisms of ATG5 and ATG7 (show ATG7 Proteins) could contribute to neutrophilic airway inflammation in the pathogenesis of adult asthma.
The authors identified a homozygous missense mutation, changing a conserved amino acid, in ATG5 in two siblings with congenital ataxia (show USP14 Proteins), mental retardation, and developmental delay.
Beclin 1 and ATG5 play important roles in regulating both Obatoclax-induced autophagy and apoptosis in adenoid cystic carcinoma.
study established a relationship between trans-eSNPs of ATG5 and lupus nephritis in a northern Han population from China
in the presence of 3-MA and Atg5 siRNA, autophagy was inhibited, LC3 (show MAP1LC3A Proteins)-II expression decreased and cell apoptosis increased
This study demonstrated an association of ATG5 rs573775 with BD and ATG10 rs4703863 with VKH syndrome in a Chinese Han population.
KIM-1-/TIM-1 (show HAVCR1 Proteins)-mediated phagocytosis links ATG5-/ULK1 (show ULK1 Proteins)-dependent clearance of apoptotic cells to antigen presentation.
Analysis of hepatitis B virus capsid maturation steps revealed that Rab33B and Atg5/12/16L1 are required for proper particle assembly and/or stability.
provide an insight into a model for swapping ATG5 partners for autophagosome maturation
miR-30b inhibited autophagy to alleviate hepatic ischemia-reperfusion injury by decreasing the Atg12-Atg5 conjugate.
These findings highlight the cell-autonomous requirement of Atg5 in the survival of adult-generated neurons.
Atg5 or Atg7 (show ATG7 Proteins) deletion in the chondrocytes promotes caspase (show CASP3 Proteins)-dependent cell death and leads to mild growth retardation
Data show that sequestosome 1 protein p62 deficiency increased atherosclerotic plaque burden in mice with a macrophage-specific ablation of autophagy-related 5 protein ATG5.
Arg-24 of Atg16L1 (show ATG16L1 Proteins) is crucial for its interaction with Atg5 which has implications in the binding of the dimeric complex to Rab33B (show RAB33B Proteins)
This work identifies a previously unrecognized role for alphav and the autophagy components LC3 and atg5 in regulating TLR signalling and B-cell immunity.
Treg cell-specific deletion of Atg5 leads to loss of Treg cells, greater tumor resistance and development of inflammatory disorders.
The results in a potent increase in odontoblastic cell differentiation, indicating the unique involvement of Atg5, autophagy and Wnt5 (show WNT5A Proteins) signaling in CS/BMP-4 (show BMP4 Proteins)-induced differentiation of ES cells into odontoblast-like cells, at a relatively early stage.
Deletion of Atg5 in chondrocytes promoted age-related osteoarthritis, but no difference in the development of post-traumatic osteoarthritis.
the unique involvement of Atg5 in IL-1beta (show IL1B Proteins)-induced proliferation of embryonic stem cell-derived odontoblast-like cells
Data indicate that the expression of MAP1LC3A (show MAP1LC3A Proteins), B and autophagy-associated genes (ATG5, mTOR (show FRAP1 Proteins), Beclin-1 (show BECN1 Proteins)) was increased in normal pigs, while decreased in miniature pigs.
Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity).
, ATG5 autophagy related 5 homolog
, APG5 autophagy 5-like
, autophagy 5-like protein
, autophagy protein 5
, apoptosis specific protein
, apoptosis-specific protein
, autophagy-related 5
, potential preautophagosome nucleating protein Atg5