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Browse our Cathepsin L1 Proteins (CTSL1)

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Cathepsin L1 Proteins (CTSL1)
On are 43 Cathepsin L1 (CTSL1) Proteins from 16 different suppliers available. Additionally we are shipping Cathepsin L1 Antibodies (181) and Cathepsin L1 Kits (52) and many more products for this protein. A total of 289 Cathepsin L1 products are currently listed.
1190035F06Rik, CATHL, CatL, cpl-1, Ctsl, Ctsl1, CTSL2, fs, MEP, MGC80629, MGC107932, nkt, si:dkey-121a11.6
list all proteins Gene Name GeneID UniProt
CTSL1 1514 P07711
CTSL1 13039 P06797
CTSL1 25697 P07154

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Cathepsin L1 Proteins (CTSL1) by Origin

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Top referenced Cathepsin L1 Proteins

  1. Human Cathepsin L1 Protein expressed in Human Cells - ABIN2002949 : Mason, Wilcox, Wikstrom, Shaw: The identification of active forms of cysteine proteinases in Kirsten-virus-transformed mouse fibroblasts by use of a specific radiolabelled inhibitor. in The Biochemical journal 1989 (PubMed)
    Show all 5 references for ABIN2002949

  2. Mouse (Murine) Cathepsin L1 Protein expressed in Human Cells - ABIN2007149 : Chauhan, Goldstein, Gottesman: Expression of cathepsin L in human tumors. in Cancer research 1991 (PubMed)
    Show all 5 references for ABIN2007149

  3. Human Cathepsin L1 Protein expressed in HEK-293 Cells - ABIN2180948 : Goretzki, Schmitt, Mann, Calvete, Chucholowski, Kramer, Günzler, Jänicke, Graeff: Effective activation of the proenzyme form of the urokinase-type plasminogen activator (pro-uPA) by the cysteine protease cathepsin L. in FEBS letters 1992 (PubMed)
    Show all 2 references for ABIN2180948

More Proteins for Cathepsin L1 Interaction Partners

Xenopus laevis Cathepsin L1 (CTSL1) interaction partners

  1. These results suggest that an antipain-sensitive protease or cathepsin L (or a related protease) is a candidate for pp25 degradation.

Human Cathepsin L1 (CTSL1) interaction partners

  1. Results showed an increase level of CTSL, and CTSB (show CTSB Proteins) in dilated cardiomyopathy patients which correlates with reduced left ventricular ejection fraction.

  2. endothelial CTSL up-regulation partially due to Fli1 (show FLI1 Proteins) deficiency may contribute to the development of vasculopathy, while the decrease in dermal CTSL expression is likely associated with dermal fibrosis in systemic sclerosis

  3. CTSL may contribute to gefitinib resistance in non-small-cell lung cancer

  4. The study results indicate the A-allele of rs3118869 [of the human cathepsin Lgene] is a protective factor in hypertension.

  5. Data suggest that nuclear cathepsin L accelerates cell cycle progression of HCT116 colorectal carcinoma cells.

  6. Mechanistic studies showed that teicoplanin blocks Ebola virus entry by specifically inhibiting the activity of cathepsin L, opening a novel avenue for the development of additional glycopeptides as potential inhibitors of cathepsin L-dependent viruses.

  7. Cathepsin L targeting in cancer treatment

  8. cathepsin L activity was decreased in p53 (show TP53 Proteins) positive cells after adriamycin treatment, but not in p53 (show TP53 Proteins) negative cells.

  9. these data indicate that the CTSL inhibitor KGP94 has the potential to alleviate metastatic disease progression and associated skeletal morbidities and hence may have utility in the treatment of advanced prostate cancer patients

  10. p41 (show EPB41 Proteins) fragment is also shown to reduce the secretion of interleukin-12 (IL-12 (show IL12A Proteins)/p70 (show ANXA6 Proteins)) during the subsequent maturation of treated dendritic cells.

Mouse (Murine) Cathepsin L1 (CTSL1) interaction partners

  1. findings suggest that single chain-cathepsin L is biologically active in promoting Th17 generation and is counter-regulated by serpinB1 (show SERPINB1 Proteins) and secondarily by asparagine endopeptidase.

  2. CTSL plays an important role in the MHC class II-mediated peptide presentation in thymic epithelial cells, acting both in the invariant chain degradation and in the generation of MHC class II-bound peptide ligands presented by cortical thymic epithelial cells. Consequently, CTSL plays an important role in the positive selection of CD4 (show CD4 Proteins)+ T cell in thymus.

  3. genetic blockade of cathepsin L activity is inferred to retard Myc (show MYC Proteins)-driven tumor growth, encouraging the potential utility of pharmacological inhibitors of cysteine cathepsins in treating late stage tumors.

  4. Double immunofluorescence analysis showed that CTLA-2alpha was co-localized with cathepsin L, cathepsin C (show CTSC Proteins), and TINAGL1 (show TINAGL1 Proteins) in placenta.

  5. CtsB (show CTSB Proteins) and CtsL are essential in alpha-syn lysosomal degradation

  6. The phenotypes of cathepsin L deficiency can be fully assigned to lack of canonically targeted cathepsin L, while the biogenesis and functionality of nucleo-cytosolic cathepsin L remain elusive.

  7. in vivo functional evidence for overexpressed CTSL as a promoter of lung metastasis, whereas high CTSL levels are maintained during tumor progression due to stress-resistant mRNA translation.

  8. cathepsin L has a protective role in mouse skin carcinogenesis

  9. Cathepsin L is involved in nociception in mice, whereas peripheral autophagy and cathepsin L contribute, at least in part, to the antinociceptive effect of dimethoxybenzylidene in mice.

  10. a degradative Ctsl-MMP-2 axis, resulting in increased MMP-2 levels upon cathepsin deficiency with subsequent degradation of secreted proteins such as collagen alpha-1 (I).

Pig (Porcine) Cathepsin L1 (CTSL1) interaction partners

  1. Endosomal acidification and cathepsin L (show CTSL Proteins) activity is required for porcine enteric calicivirus replication.

  2. CTSL1 is expressed by endometrial epithelia, placental areolae, and neonatal intestine, and it may function in the transport of macromolecules across these epithelia.

  3. These results, together with those previously reported for other genes of this family, suggest that cathepsin genes play a role in defining economically important traits in pigs.

Cow (Bovine) Cathepsin L1 (CTSL1) interaction partners

  1. The cathepsin L (show CTSL Proteins) deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.

  2. Cathepsin L (show CTSL Proteins) has an previously uncharacterized biological role in the production of [Met]enkephalin, an endogenous peptide neurotransmitter

  3. Secretory vesicle function of cathepsin L (show CTSL Proteins) for biosynthesis of active enkephalin opioid peptide contrasts with its function in lysosomes for protein degradation.

Cathepsin L1 (CTSL1) Protein Profile

Protein Summary

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with Cathepsin L1 (CTSL1)

  • cathepsin K, like (ctskl)
  • cathepsin L1 (ctsl1)
  • cathepsin L1 (CTSL1)
  • Cathepsin L1 (catl1)
  • cathepsin L1 (Tsp_11596)
  • cathepsin L (CTSL)
  • cathepsin L (Ctsl)
  • cathepsin L family member 3 (CTSL3)
  • cathepsin L1 (Ctsl1)
  • cathepsin L2 (CTSL2)
  • 1190035F06Rik protein
  • CATHL protein
  • CatL protein
  • cpl-1 protein
  • Ctsl protein
  • Ctsl1 protein
  • CTSL2 protein
  • fs protein
  • MEP protein
  • MGC80629 protein
  • MGC107932 protein
  • nkt protein
  • si:dkey-121a11.6 protein

Protein level used designations for Cathepsin L1 Proteins (CTSL1)

cathepsin L1 , cathepsin L , Cathepsin L1 , cathepsin L1-like , major excreted protein , Cat L , furless , nackt , p39 cysteine proteinase , CP-2 , MEP , cyclic protein 2 , cathepsin L2 preproprotein

567046 Danio rerio
444163 Xenopus laevis
548464 Xenopus (Silurana) tropicalis
737449 Pan troglodytes
100286607 Salmo salar
100412536 Callithrix jacchus
10912974 Trichinella spiralis
100604414 Nomascus leucogenys
1514 Homo sapiens
13039 Mus musculus
484140 Canis lupus familiaris
25697 Rattus norvegicus
396926 Sus scrofa
515200 Bos taurus
100008830 Oryctolagus cuniculus
101113725 Ovis aries
281108 Bos taurus
427466 Gallus gallus
100684364 Canis lupus familiaris
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