Browse our Cathepsin L1 Proteins (CTSL1)

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Cathepsin L1 Proteins (CTSL1)
On are 45 Cathepsin L1 (CTSL1) Proteins from 15 different suppliers available. Additionally we are shipping Cathepsin L1 Antibodies (185) and Cathepsin L1 Kits (66) and many more products for this protein. A total of 309 Cathepsin L1 products are currently listed.
26-29-p, 1190035F06Rik, CATHL, catl, Cp1, cpl-1, ctsl, Ctsl1, CTSL2, fs, LOC663234, mep, MGC80629, MGC107932, nkt, si:dkey-121a11.6
list all proteins Gene Name GeneID UniProt
CTSL1 1514 P07711
CTSL1 13039 P06797
CTSL1 25697 P07154

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Cathepsin L1 Proteins (CTSL1) by Origin

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Top referenced Cathepsin L1 Proteins

  1. Mouse (Murine) Cathepsin L1 Protein expressed in Human Cells - ABIN2007149 : Mason, Wilcox, Wikstrom, Shaw: The identification of active forms of cysteine proteinases in Kirsten-virus-transformed mouse fibroblasts by use of a specific radiolabelled inhibitor. in The Biochemical journal 1989 (PubMed)
    Show all 5 references for 2007149

  2. Human Cathepsin L1 Protein expressed in Human Cells - ABIN2002949 : Chauhan, Goldstein, Gottesman: Expression of cathepsin L in human tumors. in Cancer research 1991 (PubMed)
    Show all 5 references for 2002949

  3. Human Cathepsin L1 Protein expressed in HEK-293 Cells - ABIN2180948 : Goretzki, Schmitt, Mann, Calvete, Chucholowski, Kramer, Günzler, Jänicke, Graeff: Effective activation of the proenzyme form of the urokinase-type plasminogen activator (pro-uPA) by the cysteine protease cathepsin L. in FEBS letters 1992 (PubMed)
    Show all 2 references for 2180948

More Proteins for Cathepsin L1 Interaction Partners

Xenopus laevis Cathepsin L1 (CTSL1) interaction partners

  1. These results suggest that an antipain-sensitive protease or cathepsin L (or a related protease) is a candidate for pp25 degradation.

Human Cathepsin L1 (CTSL1) interaction partners

  1. Collectively, these data indicate that CTSL is an important contributor to tumor angiogenesis and that the CTSL inhibition may have therapeutic utility in the treatment of breast cancer patients.

  2. Therefore, we show for the first time that the nuclear localization of Cat L and its substrate Cux1can be positively regulated by Snail NLS and importin beta1, suggesting that Snail, Cat L and Cux1 all utilize importin beta1 for nuclear import.

  3. Data suggest substrate specificity of CTSL includes SNCA; CTSL truncates SNCA first at C-terminus before attacking internal beta-sheet-rich region between residues 30 and 100; three of four proteolysis sites contain glycine residues likely involved in beta-turn, where proteolysis leads to solvent exposure of internal residues and further proteolysis of amyloid. (CTSL = cathepsin L; SNCA = alpha-synuclein)

  4. Cathepsin L knockdown induced by RNA interference significantly promoted curcumin-induced cytotoxicity, apoptosis, and cell cycle arrest. The knockdown also inhibited the migration and invasion of glioma cells. Cathepsin L may be a new target to enhance the efficacy of curcumin against cancers.

  5. a positive feedback loop between Snail (show SNAI1 Proteins)-nuclear Cat L (show TRPV6 Proteins)-CUX1 (show CUX1 Proteins) drives epithelial mesenchymal transition, is reprted.

  6. CtsB (show CTSB Proteins)/L as major regulators of lysosomal function and demonstrate that CtsB (show CTSB Proteins)/L may play an important role in intracellular cholesterol trafficking and in degradation of the key AD proteins

  7. Kidney tubule/glomerulus cathepsin L expression did not change in cyclosporine A-treated nephrotic syndrome.

  8. interactions of human family 1 & 2 cystatins with cathepsin L1

  9. cathepsin L and cathepsin B (show CTSB Proteins) as the lysosomal cysteine proteases that activate the PEDV spike.

  10. the crystal structure determined at 1.4 A revealed that the cathepsin L molecule is cleaved, with the cleaved region trapped in the active site cleft of the neighboring molecule.

Mouse (Murine) Cathepsin L1 (CTSL1) interaction partners

  1. Exposure of J774A.1 cells to HOCl or HOSCN resulted in a significant decrease in the activity of the Cys (show DNAJC5 Proteins)-dependent cathepsins B and L, but not the Asp (show C3 Proteins)-dependent cathepsin D (show CTSD Proteins).

  2. findings suggest that single chain-cathepsin L is biologically active in promoting Th17 generation and is counter-regulated by serpinB1 (show SERPINB1 Proteins) and secondarily by asparagine endopeptidase.

  3. CTSL plays an important role in the MHC class II-mediated peptide presentation in thymic epithelial cells, acting both in the invariant chain degradation and in the generation of MHC class II-bound peptide ligands presented by cortical thymic epithelial cells. Consequently, CTSL plays an important role in the positive selection of CD4 (show CD4 Proteins)+ T cell in thymus.

  4. genetic blockade of cathepsin L activity is inferred to retard Myc (show MYC Proteins)-driven tumor growth, encouraging the potential utility of pharmacological inhibitors of cysteine cathepsins in treating late stage tumors.

  5. Double immunofluorescence analysis showed that CTLA-2alpha was co-localized with cathepsin L, cathepsin C (show CTSC Proteins), and TINAGL1 (show TINAGL1 Proteins) in placenta.

  6. CtsB (show CTSB PLURAL_@34956@) and CtsL are essential in alpha-syn lysosomal degradation

  7. The phenotypes of cathepsin L deficiency can be fully assigned to lack of canonically targeted cathepsin L, while the biogenesis and functionality of nucleo-cytosolic cathepsin L remain elusive.

  8. in vivo functional evidence for overexpressed CTSL as a promoter of lung metastasis, whereas high CTSL levels are maintained during tumor progression due to stress-resistant mRNA translation.

  9. cathepsin L has a protective role in mouse skin carcinogenesis

  10. Cathepsin L is involved in nociception in mice, whereas peripheral autophagy and cathepsin L contribute, at least in part, to the antinociceptive effect of dimethoxybenzylidene in mice.

Pig (Porcine) Cathepsin L1 (CTSL1) interaction partners

  1. Endosomal acidification and cathepsin L (show CTSL PLURAL_@34956@) activity is required for porcine enteric calicivirus replication.

  2. CTSL1 is expressed by endometrial epithelia, placental areolae, and neonatal intestine, and it may function in the transport of macromolecules across these epithelia.

  3. These results, together with those previously reported for other genes of this family, suggest that cathepsin genes play a role in defining economically important traits in pigs.

Cow (Bovine) Cathepsin L1 (CTSL1) interaction partners

  1. The cathepsin L (show CTSL PLURAL_@34956@) deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.

  2. Cathepsin L (show CTSL PLURAL_@34956@) has an previously uncharacterized biological role in the production of [Met]enkephalin, an endogenous peptide neurotransmitter

  3. Secretory vesicle function of cathepsin L (show CTSL PLURAL_@34956@) for biosynthesis of active enkephalin opioid peptide contrasts with its function in lysosomes for protein degradation.

Cathepsin L1 (CTSL1) Protein Profile

Protein Summary

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with Cathepsin L1 (CTSL1)

  • cathepsin L (CTSL)
  • cathepsin L (Ctsl)
  • cathepsin L1 (Ctsl1)
  • cathepsin L1 (CTSL1)
  • cathepsin L2 (CTSL2)
  • cathepsin L1 (ctsl1)
  • Cathepsin L1 (catl1)
  • cathepsin L (TcasGA2_TC009486)
  • Cathepsin L (catl)
  • cathepsin L1 (Tsp_11596)
  • cathepsin L (LOC100305013)
  • cathepsin K, like (ctskl)
  • cathepsin L family member 3 (CTSL3)
  • 26-29-p protein
  • 1190035F06Rik protein
  • CATHL protein
  • catl protein
  • Cp1 protein
  • cpl-1 protein
  • ctsl protein
  • Ctsl1 protein
  • CTSL2 protein
  • fs protein
  • LOC663234 protein
  • mep protein
  • MGC80629 protein
  • MGC107932 protein
  • nkt protein
  • si:dkey-121a11.6 protein

Protein level used designations for Cathepsin L1 Proteins (CTSL1)

cathepsin L1 , major excreted protein , Cat L , furless , nackt , p39 cysteine proteinase , CP-2 , MEP , cathepsin L , cyclic protein 2 , Cathepsin L1 , cathepsin L1-like , cathepsin L2 preproprotein , 26-29kD-proteinase , cysteine proteinase-1 , Cathepsin L

1514 Homo sapiens
13039 Mus musculus
25697 Rattus norvegicus
396926 Sus scrofa
427466 Gallus gallus
444163 Xenopus laevis
515200 Bos taurus
548464 Xenopus (Silurana) tropicalis
737449 Pan troglodytes
100008830 Oryctolagus cuniculus
100286607 Salmo salar
100412536 Callithrix jacchus
281108 Bos taurus
663234 Tribolium castaneum
694569 Macaca mulatta
100166071 Acyrthosiphon pisum
100305208 Oncorhynchus mykiss
10912974 Trichinella spiralis
100604414 Nomascus leucogenys
100305013 Ictalurus punctatus
567046 Danio rerio
484140 Canis lupus familiaris
101113725 Ovis aries
100684364 Canis lupus familiaris
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