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Mouse (Murine) Cathepsin S Protein expressed in Human Cells - ABIN3216406
Wiederanders, Brömme, Kirschke, von Figura, Schmidt, Peters: Phylogenetic conservation of cysteine proteinases. Cloning and expression of a cDNA coding for human cathepsin S. in The Journal of biological chemistry 1992
Show all 5 references for ABIN3216406
Human Cathepsin S Protein expressed in Human Cells - ABIN2002951
Shi, Webb, Foster, Knoll, Lemere, Munger, Chapman: Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. in The Journal of biological chemistry 1994
Show all 4 references for ABIN2002951
Human Cathepsin S Protein expressed in Escherichia coli (E. coli) - ABIN1098767
Fengler, Brandt: Three-dimensional structures of the cysteine proteases cathepsins K and S deduced by knowledge-based modelling and active site characteristics. in Protein engineering 1999
Show all 2 references for ABIN1098767
Human Cathepsin S Protein expressed in HEK-293 Cells - ABIN2180950
Burkard, Planyavsky, Kaupe, Breitwieser, Bürckstümmer, Bennett, Superti-Furga, Colinge: Initial characterization of the human central proteome. in BMC systems biology 2011
levels of cathepsin S and hsCRP observed in women who later developed breast cancer may provide prognostic information regarding tumor development and need to be evaluated in prospective studies.
p41 (show EPB41 Proteins) fragment is also shown to reduce the secretion of interleukin-12 (IL-12 (show IL12A Proteins)/p70 (show ANXA6 Proteins)) during the subsequent maturation of treated dendritic cells.
shedding of surface proteins by extracellular cathepsins impacts intracellular signaling as demonstrated for regulation of Ras GTPase (show RACGAP1 Proteins) activity.
the essential role of autophagy-regulated early ROS (show ROS1 Proteins) in triggering late apoptotic signaling
Cathepsin S cleaves near the N-terminus of PAR2 (show F2RL1 Proteins) to expose a novel tethered ligand, KVDGTS.
Increased plasma CTSS concentration is associated with atherogenesis.
results identify Cat-S as a biased agonist of PAR2 (show F2RL1 Proteins) that causes PAR2 (show F2RL1 Proteins)- and TRPV4 (show TRPV4 Proteins)-dependent inflammation and pain.
Its stability at neutral pH and potent proteolytic activity on extracellular matrix components mean that cathepsin S may contribute significantly to cartilage degradation and may thus be considered a potential drug target in joint diseases.
High cathepsin S expression at the primary site correlates with decreased brain metastasis-free survival in breast cancer patients.
cathepsin S and chemerin (show RARRES2 Proteins) only correlated positively with insulin (show INS Proteins) resistance and inflammation
Ctss induction during muscular dystrophy is a pathologic event that partially underlies disease pathogenesis, and its inhibition might serve as a new therapeutic strategy in Duchenne muscular dystrophy (show DMD Proteins).
Demonstrate the utility of intracellular caspase 1 (show CASP1 Proteins) and extracellular CTSS proteolytic activities as surrogate biomarkers of lysosomal rupture and acute inflammation.
Fluorogen substrate, Mca (show RSPH1 Proteins)-GRWPPMGLPWE-Lys (show LYZ Proteins)(Dnp)-DArg-NH2 can detect CTSS activities in mouse antigen presenting cells.
Data show that cathepsins S (CatS) regulates CCL2 (show CCL2 Proteins) chemokine (show CCL1 Proteins) expression by modulation of CD74 (show CD74 Proteins) antigen processing.
Cathepsin S activates MrgprC11 (show MRGPRX1 Proteins) and evokes receptor-dependent scratching in mice.
cathepsin S deficiency alters the balance between adipocyte and osteoblast differentiation, increases bone turnover, and changes bone microarchitecture. Therefore, bone and fat metabolisms should be monitored when using cathepsin S inhibitors clinically
Cathepsin S contributes to macrophage migration via degradation of elastic fibre integrity to facilitate neointima formation of vein grafts
cysteine cathepsins B and S can directly cleave Rip1 (show RALBP1 Proteins)
CatS also reduced myocardial Smad2 (show SMAD2 Proteins) and Smad3 (show SMAD3 Proteins) activation and extra domain A fibronectin (show FN1 Proteins) expression
These results, together with those previously reported for other genes of this family, suggest that cathepsin genes play a role in defining economically important traits in pigs.
The cathepsin S deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, cathepsin S, gene 1
, Cathepsin S
, Cat S