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Mouse (Murine) Cathepsin S Protein expressed in Human Cells - ABIN3216406
Wiederanders, Brömme, Kirschke, von Figura, Schmidt, Peters: Phylogenetic conservation of cysteine proteinases. Cloning and expression of a cDNA coding for human cathepsin S. in The Journal of biological chemistry 1992
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Human Cathepsin S Protein expressed in Human Cells - ABIN2002951
Shi, Webb, Foster, Knoll, Lemere, Munger, Chapman: Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. in The Journal of biological chemistry 1994
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Overall, these results indicate that exploitation of the cathepsin S activity in MPS tissues can be utilized to substantially lower non-target accumulation, suggesting this is a promising approach for the development of diagnostic and radiotherapeutic nanomedicine platforms.
polymorphism of rs7534124 and rs1136774 in cathepsin S promoter may decrease the susceptibility of asthma in a Chinese Han population
cathepsin S mRNA (CTSS), which encodes a cysteine protease (show CTSB Proteins) associated with angiogenesis and atherosclerosis, is highly edited in human endothelial cells. RNA editing enables the recruitment of the stabilizing RNA-binding protein (show PTBP1 Proteins) human antigen R (HuR (show ELAVL1 Proteins); encoded by ELAVL1 (show ELAVL1 Proteins)) to the 3' UTR of the CTSS transcript, thereby controlling CTSS mRNA stability and expression.
levels of cathepsin S and hsCRP observed in women who later developed breast cancer may provide prognostic information regarding tumor development and need to be evaluated in prospective studies.
p41 (show EPB41 Proteins) fragment is also shown to reduce the secretion of interleukin-12 (IL-12 (show IL12A Proteins)/p70 (show ANXA6 Proteins)) during the subsequent maturation of treated dendritic cells.
shedding of surface proteins by extracellular cathepsins impacts intracellular signaling as demonstrated for regulation of Ras GTPase (show RACGAP1 Proteins) activity.
the essential role of autophagy-regulated early ROS (show ROS1 Proteins) in triggering late apoptotic signaling
Cathepsin S cleaves near the N-terminus of PAR2 (show F2RL1 Proteins) to expose a novel tethered ligand, KVDGTS.
Increased plasma CTSS concentration is associated with atherogenesis.
results identify Cat-S as a biased agonist of PAR2 (show F2RL1 Proteins) that causes PAR2 (show F2RL1 Proteins)- and TRPV4 (show TRPV4 Proteins)-dependent inflammation and pain.
the roles of CTSB (show CTSB Proteins)/S and SIRT1 (show SIRT1 Proteins) in the regulation of hepatic inflammation using primary parenchymal and non-parenchymal hepatic cell types and cell lines.
Cathepsin S activity controls injury-related vascular remodeling via TLR2/p38MAPK (show MAPK14 Proteins)/PI3K/Akt (show AKT1 Proteins)/p-HDAC6 (show HDAC6 Proteins) signaling pathway.
Loss of Rab3D (show RAB3D Proteins) from secretory vesicles, leading to disproportionate Rab27 (show RAB27A Proteins)-to-Rab3D (show RAB3D Proteins) activity, may contribute to the enhanced release of cathepsin S in tears of patients with Sjogren's syndrome.
Ctss induction during muscular dystrophy is a pathologic event that partially underlies disease pathogenesis, and its inhibition might serve as a new therapeutic strategy in Duchenne muscular dystrophy (show DMD Proteins).
Demonstrate the utility of intracellular caspase 1 (show CASP1 Proteins) and extracellular CTSS proteolytic activities as surrogate biomarkers of lysosomal rupture and acute inflammation.
Fluorogen substrate, Mca (show RSPH1 Proteins)-GRWPPMGLPWE-Lys (show LYZ Proteins)(Dnp)-DArg-NH2 can detect CTSS activities in mouse antigen presenting cells.
Data show that cathepsins S (CatS) regulates CCL2 (show CCL2 Proteins) chemokine (show CCL1 Proteins) expression by modulation of CD74 (show CD74 Proteins) antigen processing.
Cathepsin S activates MrgprC11 (show MRGPRX1 Proteins) and evokes receptor-dependent scratching in mice.
cathepsin S deficiency alters the balance between adipocyte and osteoblast differentiation, increases bone turnover, and changes bone microarchitecture. Therefore, bone and fat metabolisms should be monitored when using cathepsin S inhibitors clinically
These results, together with those previously reported for other genes of this family, suggest that cathepsin genes play a role in defining economically important traits in pigs.
The cathepsin S deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, cathepsin S, gene 1
, Cathepsin S
, Cat S