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CISD2 could be an independent prognostic factor for PC and suggested that the CISD2/Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) pathway contributed to the proliferation of PC and EMT (show ITK ELISA Kits)
the patient that we describe in this report with the c.215A > G missense CISD2 variant had the classical features of Wolfram syndrome type 1. The c.215A > G (p.Asn72Ser) variant does not induce CISD2 RNA mis (show AMH ELISA Kits)-splicing or a reduction in CISD2 protein levels. Thus, we report a novel missense homozygous CISD2 mutation in a patient with clinical features that differ from previously reported Wolfram syndrome 2 case reports.
CISD2 exerts anti-apoptotic and anti-inflammatory effects in neural cells; and (2) curcumin can attenuate the downregulation of CISD2 in SCI and LPS (show IRF6 ELISA Kits)-treated astrocytes.
CISD2 protein may serve as a candidate prognostic marker and a novel therapeutic target for hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) and play an important role in promoting proliferation and enhanced progression of HCC (show FAM126A ELISA Kits).
The findings suggested that CISD2 haplotype-tagging single nucleotide polymorphisms are not associated with Alzheimer's disease risk.
NAF-1 (show TNIP1 ELISA Kits) is a BCL-2 (show BCL2 ELISA Kits)-associated co-factor that targets BCL-2 (show BCL2 ELISA Kits) for antagonism of the autophagy pathway at the endoplasmic reticulum.
NAF-1 (show TNIP1 ELISA Kits) as a previously unidentified cell target of anti-diabetes thiazolidinedione drugs.
provides the first structural information, to our knowledge, for future targeting of the NAF-1 (show TNIP1 ELISA Kits)-Bcl-2 (show BCL2 ELISA Kits) complex in the regulation of apoptosis/autophagy in cancer biology
High CISD2 expression was significantly associated with gastric cancer.
NAF-1 (show TNIP1 ELISA Kits) is a major player in the metabolic regulation of breast cancer cells.
These studies define a novel role for ABIN1 (show TNIP1 ELISA Kits) dysfunction and NF-kappaB (show NFKB1 ELISA Kits) in mediating glomerulonephritis through proinflammatory activation of podocytes.
Suppression of IRAK1 (show IRAK1 ELISA Kits) or IRAK4 (show IRAK4 ELISA Kits) Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1 (show TNIP1 ELISA Kits)
NAF-1 (show TNIP1 ELISA Kits), a BCL-2 (show BCL2 ELISA Kits)-associated autophagy regulator, is required for homeostatic maintenance of skeletal muscle
Cisd2 deficiency impairs the activation of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling
These results suggest that the ABIN1 (show TNIP1 ELISA Kits)-mediated hyperactivation of IKKs and MAPKs might mediate chronic inflammation and CVD development.
Results suggest that that Cisd2 plays an important role in intracellular Ca21 homeostasis, which is required for the differentiation and functioning of adipocytes as well as the regulation of glucose homeostasis in mice.
Miner1 is a redox protein that resides in the ER and that regulates the UPR and mitochondrial function.
studies link ABIN-1 (show TNIP1 ELISA Kits) with IL-23 (show IL23A ELISA Kits) and IL-17 (show IL17A ELISA Kits), and they provide cellular and molecular mechanisms by which ABIN-1 (show TNIP1 ELISA Kits) regulates susceptibility to psoriasis.
data reveal ABIN1 (show TNIP1 ELISA Kits) as an essential anti-inflammatory component of TLR-signaling pathways that controls C/EBPbeta (show CEBPB ELISA Kits) activity
ABIN1 (show TNIP1 ELISA Kits) requires its ubiquitin binding domain and cooperates with TAX1BP1 (show TAX1BP1 ELISA Kits) and A20 (show TNFAIP3 ELISA Kits) to restrict antiviral signaling.
The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2.
CDGSH iron-sulfur domain-containing protein 2A
, CDGSH iron sulfur domain-containing protein 2A
, CDGSH iron sulfur domain-containing protein 2-A
, zinc finger, CDGSH-type domain 2
, CDGSH iron-sulfur domain-containing protein 2
, CDGSH iron sulfur domain-containing protein 2
, CDGSH iron sulfur domain-containing protein 2-B
, CDGSH iron sulfur domain-containing protein 2B
, CDGSH iron-sulfur domain-containing protein 2B
, endoplasmic reticulum intermembrane small protein
, mitoNEET related 1
, mitoNEET-related 1 protein
, nutrient-deprivation autophagy factor-1
, CDGSH iron sulfur domain 2
, nervous system over-expressed protein 70
, nervous system overexpressed protein 70
, H/ACA ribonucleoprotein complex non-core subunit NAF1
, nuclear assembly factor 1 homolog
, A20-binding inhibitor of NF-kappa B activation
, Nef-associated factor 1
, TNFAIP3-interacting protein 1
, virion-associated nuclear shuttling protein