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Hsp10 (show HSPE1 Antibodies) and Hsp60 (show HSPD1 Antibodies) may be implicated in carcinogenesis from its very early steps in colorectal cancer.
High HSP60 (show HSPD1 Antibodies) expression is associated with gastric cancer.
Elevated expression of HSPD1 (show HSPD1 Antibodies) in osteosarcoma tissues correlated with poor prognosis of the osteosarcoma patients.
The cardioprotective effect of 40-60 g/d of alcohol consumption could be due in part, to increased intracellular HSPA1A (show HSPA1A Antibodies), a potent anti-inflammatory protein. Excessive intake of alcohol increases antibodies anti-Hsp60 (show HSPD1 Antibodies), stimulating proinflammatory cytokines. This fact may explain the mortality from cardiovascular disease in heavy drinkers.
This review article presents accumulating proof that supports the idea that tolerization with antigenic HSP60 (show HSPD1 Antibodies) protein or its peptides may arrest or even prevent atherosclerosis by increased production of regulatory T cells and/or anti-inflammatory cytokines. [review]
Data show that Eclipta extract upregulates heat shock protein 60 (Hsp60 (show HSPD1 Antibodies)) which is localized in the endoplasmic reticulum (ER).
Data indicate that on addition of the heat-shock proteins GroEL (show GroEL Antibodies)-GroES (show HSPE1 Antibodies) molecular chaperone (show HSP90AA1 Antibodies) system, the folding of the nascent chemokine receptor (show CCR1 Antibodies) type 5 (CCR5 (show CCR5 Antibodies)) was significantly enhanced.
The data show that immunohistochemistry for CD1a (show CD1A Antibodies) and Hsp60 (show HSPD1 Antibodies) can be of help in differential diagnosis between Keratoacantomas and well-differentiated forms of squamous cell carcinomas.
Anti-citrullinated protein antibodies promote apoptosis of mature human osteoblasts via cell-surface binding to citrullinated heat shock protein 60 (show HSP60 Antibodies).
Heat shock protein 60 (show HSP60 Antibodies) stimulates the migration of vascular smooth muscle cells via Toll-like receptor 4 (show TLR4 Antibodies) and ERK MAPK (show MAPK1 Antibodies) activation
This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.
60 kDa chaperonin
, 60 kDa heat shock protein, mitochondrial
, P60 lymphocyte protein
, chaperonin 60
, heat shock protein 65
, mitochondrial matrix protein P1
, short heat shock protein 60 Hsp60s1