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Browse our IFIH1 Proteins (IFIH1)

Full name:
Interferon Induced with Helicase C Domain 1 Proteins (IFIH1)
On are 6 Interferon Induced with Helicase C Domain 1 (IFIH1) Proteins from 4 different suppliers available. Additionally we are shipping IFIH1 Antibodies (126) and IFIH1 Kits (9) and many more products for this protein. A total of 155 IFIH1 products are currently listed.
9130009C22Rik, Helicard, Hlcd, IDDM19, MDA-5, MDA5, RGD1560496, RLR-2
list all proteins Gene Name GeneID UniProt
IFIH1 64135 Q9BYX4
IFIH1 71586 Q8R5F7
Rat IFIH1 IFIH1 499801  

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IFIH1 Proteins (IFIH1) by Origin

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Top referenced IFIH1 Proteins

  1. Human IFIH1 Protein expressed in HEK-293 Cells - ABIN2722584 : Labrador-Horrillo, Martinez, Selva-OCallaghan, Trallero-Araguas, Balada, Vilardell-Tarres, Juárez: Anti-MDA5 antibodies in a large Mediterranean population of adults with dermatomyositis. in Journal of immunology research 2014 (PubMed)
    Show all 2 references for ABIN2722584

More Proteins for IFIH1 Interaction Partners

Rhesus Monkey Interferon Induced with Helicase C Domain 1 (IFIH1) interaction partners

  1. These findings indicate that human parainfluenza virus type 2 V binding to MDA5 is important for HPIV-2 virulence in nonhuman primates and that some V protein residues involved in MDA5 binding are not essential for efficient HPIV-2 growth in vitro.

Human Interferon Induced with Helicase C Domain 1 (IFIH1) interaction partners

  1. MDA-5 stimulation leads to endothelial dysfunction.

  2. LGP2 (show DHX58 Proteins) plays an essential role in activating interferon (show IFNA Proteins) signaling against hepatitis C virus (HCV) infection by promoting MDA5 recognition of HCV pathogen-associated molecular patterns.

  3. These data confirm the pathogenicity of IFIH1 c.2465G>A p.(Arg822Gln) for Singleton-Merten syndrome and affirm the striking phenotypic heterogeneity of this disorder

  4. RNAs isolated from HCV-replicating cells triggered robust IFN-beta (show IFNB1 Proteins) and IFN-lambda production through MDA5.

  5. deliberately targeting the evolutionarily conserved MDA-5-IPS-1 (show MAVS Proteins) antiviral pathway in tumors can provoke parallel tumoricidal and immunostimulatory effects that bridge innate and adaptive immune responses for the therapeutic treatment of cancer

  6. meta-analysis of peer-reviewed articles from 2008 to 2015 and data from this study indicated an association between rs1990760 and Systemic lupus erythematosus (SLE) onset . This is the first association analysis on IFIH1 polymorphisms and SLE susceptibility in Brazilian populations.

  7. This study reviewed that Neurologic Phenotypes Associated with Mutations in IFIH1 in patients with Aicardi-Goutieres Syndrome.

  8. We provide herein the results of pathological examination including detailed description of the neuropathological hallmarks. To our knowledge, this the first detailed clinico-pathological description of a patient with an IFIH1 pathogenic variant.

  9. Our findings indicate that although STAT4 (show STAT4 Proteins) and IFIH1 SNPs are not associated with T1D in a Brazilian population, they might play a role in susceptibility to T1D on a larger worldwide scale

  10. These results showed that mRNA levels of MDA5 and RIG-1 (show RARRES3 Proteins) were significantly decreased and increased, respectively, in chronic hepatitis B patients when compared to healthy controls.

Mouse (Murine) Interferon Induced with Helicase C Domain 1 (IFIH1) interaction partners

  1. MDA-5 stimulation leads to endothelial dysfunction.

  2. The p150 (show ABL1 Proteins) isoform of ADAR1 (show ADAR Proteins) uniquely regulated the MDA5 pathway.

  3. MDA5, detects viral RNA and triggers induction of type I interferons, chemical messengers that induce inflammation and help regulate the immune responses.

  4. Duox2 (show DUOX1 Proteins)-derived reactive oxygen species are necessary for the innate immune response and trigger the induction of RIG-I (show DDX58 Proteins) and MDA5 to resist influenza A infection in human nasal epithelium and mouse nasal mucosa.

  5. L region antisense RNA of EMCV is a key determinant of innate immunity to the virus and represents an RNA that activates LGP2 (show DHX58 Proteins) associated MDA5 in virally-infected cells.

  6. embryonic death and phenotypes of Adar1 (show ADAR Proteins)(E861A/E861A) were rescued by concurrent deletion of the cytosolic sensor of dsRNA, MDA5.

  7. IFIH1 heterozygous mice have a regulatory rather than effector T-cell response at the site of autoimmunity, supporting IFIH1 expression as an essential regulator of the diabetogenic T-cell response.

  8. Our results, therefore, suggest that Arl5B (show ARL5B Proteins) is a negative regulator for MDA5.

  9. TRIM13 (show TRIM13 Proteins) interacts with MDA5 and negatively regulates MDA5-mediated type I IFN production

  10. RIG-I and MDA-5 detection of viral RNA-dependent RNA polymerase activity restricts positive-strand RNA virus replication.

Pig (Porcine) Interferon Induced with Helicase C Domain 1 (IFIH1) interaction partners

  1. These data indicate that classical swine fever virus can be recognized by both RIG-I (show DDX58 Proteins) and MDA5 to initiate the RIG-I (show DDX58 Proteins) signaling pathway to trigger innate defenses against infection.

  2. crystal structure of the MDA5 ATP-hydrolysis domain in complex with parainfluenzavirus 5 V protein; the V protein unfolded the ATP-hydrolysis domain of MDA5 and recognized a structural motif of MDA5 normally buried in the helicase fold leading to disruption of MDA5 ATP-hydrolysis site and prevention of RNA-bound MDA5 filament formation

  3. IFIH1 had only one nonsynonymous SNP in the helicase domain.

IFIH1 Protein Profile

Protein Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents\; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19.

Alternative names and synonyms associated with IFIH1

  • interferon induced with helicase C domain 1 (IFIH1)
  • interferon induced with helicase C domain 1 (Ifih1)
  • 9130009C22Rik protein
  • Helicard protein
  • Hlcd protein
  • IDDM19 protein
  • MDA-5 protein
  • MDA5 protein
  • RGD1560496 protein
  • RLR-2 protein

Protein level used designations for IFIH1

interferon-induced helicase C domain-containing protein 1 , melanoma differentiation associated protein-5 , melanoma differentiation-associated protein 5 , CADM-140 autoantigen , DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide , RIG-I-like receptor 2 , RNA helicase-DEAD box protein 116 , clinically amyopathic dermatomyositis autoantigen 140 kDa , helicard , helicase with 2 CARD domains , murabutide down-regulated protein , interferon induced with helicase C domain protein 1 , melanoma differentiation associated protein 5

424185 Gallus gallus
459692 Pan troglodytes
702024 Macaca mulatta
64135 Homo sapiens
71586 Mus musculus
100101927 Sus scrofa
535490 Bos taurus
499801 Rattus norvegicus
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