Browse our IFIH1 Proteins (IFIH1)

On are 6 Interferon Induced with Helicase C Domain 1 (IFIH1) Proteins from 4 different suppliers available. Additionally we are shipping IFIH1 Antibodies (127) and IFIH1 Kits (10) and many more products for this protein. A total of 157 IFIH1 products are currently listed.
9130009C22Rik, Helicard, Hlcd, IDDM19, MDA-5, MDA5, RGD1560496, RLR-2
list all proteins Gene Name GeneID UniProt
IFIH1 64135 Q9BYX4
IFIH1 71586 Q8R5F7
Rat IFIH1 IFIH1 499801  

IFIH1 Proteins (IFIH1) by Origin

More Proteins for IFIH1 Interaction Partners

Rhesus Monkey Interferon Induced with Helicase C Domain 1 (IFIH1) interaction partners

  1. These findings indicate that human parainfluenza virus type 2 V binding to MDA5 is important for HPIV-2 virulence in nonhuman primates and that some V protein residues involved in MDA5 binding are not essential for efficient HPIV-2 growth in vitro.

Human Interferon Induced with Helicase C Domain 1 (IFIH1) interaction partners

  1. Data indicate autosomal recessive, homozygous MDA5 encoding gene IFIH1 mutation in the proband, and both parents and a brother were carriers of this mutation.

  2. this study shows that PACT (show RBBP6 Proteins) facilitates RNA-induced formation of MDA5 oligomers in response to viruses

  3. Human peripheral blood mononuclear cells (PBMCs) and cell lines expressing the risk variant IFIH1(T946) exhibited heightened basal and ligand-triggered production of type I interferons.

  4. Mechanistically, West Nile virus NS1 (show PTPN11 Proteins) targets RIG-I (show DDX58 Proteins) and melanoma differentiation-associated gene 5 (MDA5) by interacting with them and subsequently causing their degradation by the proteasome.

  5. The rare variant rs35667974, encoding an Ile923Val amino acid change in the IFIH1 gene protein product, is protective for psoriatic arthritis.

  6. This would suggest that the change in IP-10 (show CXCL10 Proteins) is genotypically driven, while the change in IL-6 (show IL6 Proteins) may be reflective of systemic lupus erythematosus (SLE) transition status. These data suggest that IFIH1 may contribute to SLE pathogenesis via altered inflammatory mechanisms.

  7. dynamic sumoylation and desumoylation of MDA5 and RIG-I (show DDX58 Proteins) modulate efficient innate immunity to RNA virus and its timely termination.

  8. GPATCH3 negatively regulates both RIG-I (show DDX58 Proteins)- and MDA5-mediated signaling.

  9. Data support a new model where an LGP2-MDA5 oligomer shuttles NS3 to the mitochondria to block antiviral signaling

  10. MDA-5 stimulation leads to endothelial dysfunction.

Mouse (Murine) Interferon Induced with Helicase C Domain 1 (IFIH1) interaction partners

  1. These findings imply that MDA5-induced cell death and inflammation in the pancreas facilitate progression to autoimmune destruction of pancreatic beta-cells.

  2. Mice with a knock-in mutation encoding IFIH1(T946) displayed enhanced basal expression of type I interferons, survived a lethal viral challenge and exhibited increased penetrance in autoimmune models, including a combinatorial effect with other risk variants. Furthermore, IFIH1(T946) mice manifested an embryonic survival defect consistent with enhanced responsiveness to RNA self ligands.

  3. TRIM65 as an essential component for the MDA5 signaling pathway and provide physiological evidence showing that ubiquitination is important for MDA5 oligomerization and activation.

  4. MDA-5 stimulation leads to endothelial dysfunction.

  5. The p150 (show ABL1 Proteins) isoform of ADAR1 (show ADAR Proteins) uniquely regulated the MDA5 pathway.

  6. MDA5, detects viral RNA and triggers induction of type I interferons, chemical messengers that induce inflammation and help regulate the immune responses.

  7. Duox2 (show DUOX1 Proteins)-derived reactive oxygen species are necessary for the innate immune response and trigger the induction of RIG-I (show DDX58 Proteins) and MDA5 to resist influenza A infection in human nasal epithelium and mouse nasal mucosa.

  8. L region antisense RNA of EMCV is a key determinant of innate immunity to the virus and represents an RNA that activates LGP2 (show DHX58 Proteins) associated MDA5 in virally-infected cells.

  9. embryonic death and phenotypes of Adar1 (show ADAR Proteins)(E861A/E861A) were rescued by concurrent deletion of the cytosolic sensor of dsRNA, MDA5.

  10. IFIH1 heterozygous mice have a regulatory rather than effector T-cell response at the site of autoimmunity, supporting IFIH1 expression as an essential regulator of the diabetogenic T-cell response.

Pig (Porcine) Interferon Induced with Helicase C Domain 1 (IFIH1) interaction partners

  1. study identifies the porcine 2'-5'-oligoadenylate synthetase-like protein (pOASL) as an interferon (show IFNA Proteins) (IFN)-stimulated gene (ISG) against classical swine fever virus (CSFV); show that pOASL, as an MDA5-interacting protein, is a coactivator of MDA5-mediated IFN induction to exert anti-CSFV actions

  2. These data indicate that classical swine fever virus can be recognized by both RIG-I (show DDX58 Proteins) and MDA5 to initiate the RIG-I (show DDX58 Proteins) signaling pathway to trigger innate defenses against infection.

  3. crystal structure of the MDA5 ATP-hydrolysis domain in complex with parainfluenzavirus 5 V protein; the V protein unfolded the ATP-hydrolysis domain of MDA5 and recognized a structural motif of MDA5 normally buried in the helicase fold leading to disruption of MDA5 ATP-hydrolysis site and prevention of RNA-bound MDA5 filament formation

  4. IFIH1 had only one nonsynonymous SNP in the helicase domain.

IFIH1 Protein Profile

Protein Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents\; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19.

Alternative names and synonyms associated with IFIH1

  • interferon induced with helicase C domain 1 (IFIH1)
  • interferon induced with helicase C domain 1 (Ifih1)
  • 9130009C22Rik protein
  • Helicard protein
  • Hlcd protein
  • IDDM19 protein
  • MDA-5 protein
  • MDA5 protein
  • RGD1560496 protein
  • RLR-2 protein

Protein level used designations for IFIH1

interferon-induced helicase C domain-containing protein 1 , melanoma differentiation associated protein-5 , melanoma differentiation-associated protein 5 , CADM-140 autoantigen , DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide , RIG-I-like receptor 2 , RNA helicase-DEAD box protein 116 , clinically amyopathic dermatomyositis autoantigen 140 kDa , helicard , helicase with 2 CARD domains , murabutide down-regulated protein , interferon induced with helicase C domain protein 1 , melanoma differentiation associated protein 5

424185 Gallus gallus
459692 Pan troglodytes
702024 Macaca mulatta
64135 Homo sapiens
71586 Mus musculus
100101927 Sus scrofa
535490 Bos taurus
499801 Rattus norvegicus
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