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Browse our ITCH Proteins (ITCH)

Full name:
Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Proteins (ITCH)
On are 6 Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH) Proteins from 4 different suppliers available. Additionally we are shipping ITCH Antibodies (72) and ITCH Kits (3) and many more products for this protein. A total of 90 ITCH products are currently listed.
6720481N21Rik, 8030492O04Rik, A130065M08, AIF4, AIP4, C230047C07Rik, dJ468O1.1, NAPP1
list all proteins Gene Name GeneID UniProt
ITCH 83737 Q96J02
ITCH 16396 Q8C863

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ITCH Proteins (ITCH) by Origin

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Top referenced ITCH Proteins

  1. Human ITCH Protein expressed in Escherichia coli (E. coli) - ABIN2003996 : Marchese, Raiborg, Santini, Keen, Stenmark, Benovic: The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. in Developmental cell 2003 (PubMed)
    Show all 5 references for ABIN2003996

More Proteins for ITCH Interaction Partners

Human Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH) interaction partners

  1. Results indicate that TAX1BP1 (show TAX1BP1 Proteins) functions as an adaptor molecule for Itch to target MAVS (show MAVS Proteins) during RNA virus infection and thus restrict virus-induced apoptosis.

  2. These data demonstrate that Itch, ubiquitin, and Alix (show PDCD6IP Proteins) control the BFRF1-mediated modulation of the nuclear envelope and human herpesvirus 4 maturation, uncovering novel regulatory mechanisms of nuclear egress of viral nucleocapsids.

  3. The authors demonstrate that the PPxY L domain motif of ebolavirus VP40 interacts specifically with the WW domain of the host E3 ubiquitin ligase (show MUL1 Proteins) ITCH.

  4. Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch.

  5. cir (show KCNJ5 Proteins)-ITCH may play an inhibitory role in lung cancer progression by enhancing its parental gene, ITCH, expression

  6. Itch monoubiquitinates SMN (show STMN1 Proteins) and monoubiquitination of SMN (show STMN1 Proteins) plays an important role in regulating its cellular localization.

  7. miR (show MLXIP Proteins)-106b, which itself is down regulated in metastatic pancreatic cancer, directly interacts and inhibits ITCH expression.

  8. LRAD3 is a component of pathways that function effectively to modulate Itch and Nedd4 auto-ubiquitination and levels.

  9. Cytomegalovirus UL42 induced the ubiquitination and degradation of human Itch in virus-infected fibroblasts, and was partially colocalized with p62 (show GTF2H1 Proteins), a ubiquitin-binding protein, and CD63 (show CD63 Proteins), a marker of lysosome and multivesicular bodies.

  10. catalytic activity of Itch toward different SH3 domain-containing proteins was similar, except for beta-PIX (show ARHGEF7 Proteins) that was not readily ubiquitylated even though it could interact with an affinity comparable to those of other substrates tested

Mouse (Murine) Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH) interaction partners

  1. this study identified a previously unknown role for Itch in regulating IL-17 (show IL17A Proteins)-mediated colonic inflammation and carcinogenesis

  2. Itch monoubiquitinates SMN (show STMN1 Proteins) and monoubiquitination of SMN (show STMN1 Proteins) plays an important role in regulating its cellular localization.

  3. ITCH targets TXNIP (show TXNIP Proteins) for ubiquitin-proteasome degradation in cardiomyocytes and ameliorates reactive oxygen species-induced cardiotoxicity through the thioredoxin (show TXN Proteins) system.

  4. CUL4B links two distinct spermatogenetic processes to a single E3 ligase, highlighting the significance of ubiquitin modification during spermatogenesis.

  5. Impaired ITCH results in heightened TNF (show TNF Proteins) signaling. ITCH-/- mouse's spontaneous lung inflammation and subsequent death can be delayed when TNF (show TNF Proteins) signaling is genetically deleted.

  6. ITCH modulates SIRT6 (show SIRT6 Proteins) and SREBP2 (show SREBF2 Proteins) to influence lipid metabolism and atherosclerosis in ApoE (show APOE Proteins) null mice

  7. In the absence of Ndfip1, the Nedd4 family member Itch can bind an E2 but cannot accept ubiquitin onto its catalytic cysteine.

  8. The E3 ubiquitin ligase (show MUL1 Proteins) Itch inhibits p38alpha (show MAPK14 Proteins) signaling and skin inflammation through the ubiquitylation of Tab1 (show TAB1 Proteins).

  9. Ndfip1 (show NDFIP1 Proteins) regulates itch ligase activity and airway inflammation via UbcH7 (show UBE2L3 Proteins).

  10. The expression of Th2 cytokines by Treg cells was increased in the absence of Itch. Fate mapping revealed that a fraction of Treg cells lost Foxp3 (show FOXP3 Proteins) expression independently of Itch.

ITCH Protein Profile

Protein Summary

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with ITCH

  • itchy E3 ubiquitin protein ligase (ITCH)
  • itchy, E3 ubiquitin protein ligase (Itch)
  • 6720481N21Rik protein
  • 8030492O04Rik protein
  • A130065M08 protein
  • AIF4 protein
  • AIP4 protein
  • C230047C07Rik protein
  • dJ468O1.1 protein
  • NAPP1 protein

Protein level used designations for ITCH

E3 ubiquitin-protein ligase Itchy homolog , NFE2-associated polypeptide 1 , atrophin-1 interacting protein 4 , dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4)) , itchy E3 ubiquitin protein ligase homolog , E3 ubiquitin-protein ligase Itchy

83737 Homo sapiens
16396 Mus musculus
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