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MARCO Is Processed by either Macropinocytosis or Endocytosis-Autophagy Pathway
our data demonstrate that MARCO differentially affects TLR-induced DC activation and suggest targeting of MARCO could lead to different outcomes that depend on the inflammatory context encountered by dendritic cells.
Vaccinia virus bound directly to MARCO, and overexpression of MARCO increased susceptibility to vaccinia infection.
MARCO-/- dendritic cells demonstrated enhanced migratory capacity in response to CCL-21 (show CCL21 ELISA Kits) in vitro.
herpes simplex virus type 1 binds to MARCO to enhance its capacity for disease.
results indicate that accumulation of SQSTM1 (show SQSTM1 ELISA Kits) leads to increased activation of NFE2L2 (show NFE2L2 ELISA Kits) and the subsequent increase in MARCO and MSR1 (show MSR1 ELISA Kits)
this study, we confirm that tolerized mouse bone marrow-derived macrophages selectively increase expression of MARCO and increase phagocytosis
MARCO is an important component of anti-Streptococcus pneumoniae responses in murine nasopharyngeal macrophages during bacterial colonization.
Fetuin-A (show AHSG ELISA Kits)-containing calciprotein particles facilitate the clearance of mineral debris by macrophages via SR-A (show MSR1 ELISA Kits).
These results indicate that MARCO suppresses a protective early inflammatory response to influenza, which modulates viral clearance and delays recovery.
this translational investigation identified gene candidates, including Marco, for host susceptibility to multiple phenotypes of RSV disease in mice that closely mimic human disease, and a polymorphism in human MARCO associated with increased risk of RSV disease severity in infants.
Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI (show MSR1 ELISA Kits) and MARCO.
None of the nonsynonymous variants discovered by resequencing of the structurally similar MARCO were associated with lung function or risk of COPD (show ARCN1 ELISA Kits).
Significant associations of four SNPs and haplotypes with antibody response to cholera vaccine in three genes, MARCO, TNFAIP3 (show TNFAIP3 ELISA Kits) and CXCL12 (show CXCL12 ELISA Kits).
We identified 9 non-synonymous variants in the MARCO gene and showed that these variants are not major risk factors for COPD (show ARCN1 ELISA Kits) or lung infection. H101Q heterozygotes had increased sepsis risk.
Polymorphisms within the human class A scavenger receptor MARCO correlate with susceptibility/resistance to tuberculosis in a Gambian population.
In this review, we showed that SR-A (show MSR1 ELISA Kits) and MARCO trigger intracellular signaling, modulating pro-inflammatory and microbicidal activities of macrophages.
This review demonstrated that class A SR and MARCO are major pattern recognition receptors mediating opsonin-independent phagocytosis.
The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.
macrophage receptor MARCO
, scavenger receptor class A member 2
, scavenger receptor class A, member 2
, putative scavenger receptor MARCO