Browse our RIPK3 Proteins (RIPK3)

Full name:
Receptor-Interacting serine-threonine Kinase 3 Proteins (RIPK3)
On are 18 Receptor-Interacting serine-threonine Kinase 3 (RIPK3) Proteins from 10 different suppliers available. Additionally we are shipping RIPK3 Antibodies (156) and RIPK3 Kits (20) and many more products for this protein. A total of 206 RIPK3 products are currently listed.
2610528K09Rik, AW107945, Hcyp2, Rip3, RIPK3
list all proteins Gene Name GeneID UniProt
RIPK3 11035 Q9Y572
RIPK3 56532  
RIPK3 246240 Q9Z2P5

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RIPK3 Proteins (RIPK3) by Origin

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Top referenced RIPK3 Proteins

  1. Human RIPK3 Protein expressed in Wheat germ - ABIN1318116 : Northington, Chavez-Valdez, Graham, Razdan, Gauda, Martin: Necrostatin decreases oxidative damage, inflammation, and injury after neonatal HI. in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2011 (PubMed)

More Proteins for RIPK3 Interaction Partners

Human Receptor-Interacting serine-threonine Kinase 3 (RIPK3) interaction partners

  1. Renal clear cell carcinoma cells cells express increased amounts of RIPK1 (show RIPK1 Proteins) and RIPK3 and are poised to undergo necroptosis in response to TNFR1 (show TNFRSF1A Proteins) signaling.

  2. The results highlight a new role of TSC2 in protecting glioblastoma against photodynamic therapy-induced cell death, and TSC2 and YWHAZ (show YWHAZ Proteins) as new RIP3 partners.

  3. inactivation of RIP1 (show UQCRFS1 Proteins)/RIP3 resulted in reduction of SOCS1 (show SOCS1 Proteins) protein levels and partial differentiation of AML (show RUNX1 Proteins) cells. AML (show RUNX1 Proteins) cells with inactivated RIP1 (show UQCRFS1 Proteins)/RIP3 signaling show increased sensitivity to IFN-gamma-induced (show SAMHD1 Proteins) differentiation.

  4. results reveal a pathway for MLKL-dependent programmed necrosis that is executed in the absence of RIPK3 and potentially drives the pathogenesis of severe liver diseases.

  5. Necroptosis signaling is modulated by the kinase RIPK1 and requires the kinase RIPK3 and the pseudokinase MLKL. (Review)

  6. Data identify RIPK3 and the inflammasome as key tumor suppressors in acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)).

  7. Results suggest that impaired hepatic proteasome function by alcohol exposure may contribute to hepatic accumulation of RIP3 resulting in necroptosis and steatosis while RIP1 (show UQCRFS1 Proteins) kinase activity is important for alcohol-induced inflammation.

  8. CHIP is a bona fide negative regulator of the RIPK1 (show RIPK1 Proteins)-RIPK3 necrosome formation leading to desensitization of TNF (show TNF Proteins)-mediated necroptosis

  9. CNOT3 (show CNOT3 Proteins) suppression promotes necroptosis by stabilizing mRNAs for cell death-inducing proteins, Ripk1 (show RIPK1 Proteins) and Ripk3.

  10. RIPK3 expression may allow unmasking the necroptotic signalling machinery in melanoma and points to reactivation of this pathway as a treatment option for metastatic melanoma.

Mouse (Murine) Receptor-Interacting serine-threonine Kinase 3 (RIPK3) interaction partners

  1. robust caspase (show CASP3 Proteins) activation in NEMO (show IKBKG Proteins)-deficient cells is concomitant with RIPK3 recruitment to the apoptosis-mediating complex.

  2. study identifies a novel role for RIPK1 (show RIPK1 Proteins) and RIPK3, a pair of homologous serine/threonine kinases previously implicated in the regulation of necroptosis and pathologic tissue injury, in directing IFN-beta (show IFNB1 Proteins) production in macrophages

  3. this study shows that RIPK1 (show RIPK1 Proteins) and RIPK3 account for acute inflammatory responses induced by lipopolysaccharide in vivo; notably, this regulation does not require exogenous manipulation of caspases

  4. RIPK3 and/or MLKL may exert functions independently of necroptosis.

  5. These results identify DAI (show ZBP1 Proteins) as a link between influenza A virus replication and RIPK3 activation and implicate DAI (show ZBP1 Proteins) as a sensor of RNA viruses.

  6. results reveal a pathway for MLKL-dependent programmed necrosis that is executed in the absence of RIPK3 and potentially drives the pathogenesis of severe liver diseases.

  7. Mice deficient in RIPK3 or doubly deficient in MLKL and FADD (show FADD Proteins), but not MLKL alone, are more susceptible to influenza A virus than their wild-type counterparts, revealing an important role for RIPK3-mediated apoptosis in antiviral immunity.

  8. These data suggest that Rip3 plays a role in neurodegeneration and mitochondrial morphology in the absence of mitochondrial division.

  9. RIPK3 regulates type I IFN both transcriptionally, by interacting with MAVS (show MAVS Proteins) and limiting RIPK1 (show RIPK1 Proteins) interaction with MAVS (show MAVS Proteins), and post-transcriptionally.

  10. Using a mouse model of West Nile virus encephalitis, study shows that RIPK3 restricts WNV pathogenesis independently of cell death. Ripk3(-/-) mice exhibited enhanced mortality compared to wild-type controls.

RIPK3 Protein Profile

Protein Summary

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.

Alternative names and synonyms associated with RIPK3

  • receptor-interacting serine-threonine kinase 3 (RIPK3)
  • receptor-interacting serine-threonine kinase 3 (ripk3)
  • receptor-interacting serine-threonine kinase 3 (Ripk3)
  • 2610528K09Rik protein
  • AW107945 protein
  • Hcyp2 protein
  • Rip3 protein
  • RIPK3 protein

Protein level used designations for RIPK3

receptor-interacting serine-threonine kinase 3 , receptor-interacting serine/threonine-protein kinase 3-like , RIP-3 , RIP-like protein kinase 3 , receptor interacting protein 3 , receptor-interacting protein 3 , receptor-interacting serine/threonine-protein kinase 3 , mRIP3 , homocysteine respondent protein HCYP2

452820 Pan troglodytes
100461174 Pongo abelii
733239 Xenopus laevis
11035 Homo sapiens
56532 Mus musculus
246240 Rattus norvegicus
608486 Canis lupus familiaris
507427 Bos taurus
100734737 Cavia porcellus
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