Browse our anti-TMEM173 (TMEM173) Antibodies

Full name:
anti-Transmembrane Protein 173 Antibodies (TMEM173)
On are 143 Transmembrane Protein 173 (TMEM173) Antibodies from 24 different suppliers available. Additionally we are shipping TMEM173 Proteins (11) and TMEM173 Kits (3) and many more products for this protein. A total of 164 TMEM173 products are currently listed.
2610307O08Rik, ERIS, Mita, MPYS, NET23, RGD1562552, STING
list all antibodies Gene Name GeneID UniProt
TMEM173 340061 Q86WV6
TMEM173 72512 Q3TBT3
TMEM173 498840  

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Top referenced anti-TMEM173 Antibodies

  1. Human Polyclonal TMEM173 Primary Antibody for ICC, IF - ABIN4356573 : Furr, Chauhan, Moerdyk-Schauwecker, Marriott: A role for DNA-dependent activator of interferon regulatory factor in the recognition of herpes simplex virus type 1 by glial cells. in Journal of neuroinflammation 2011 (PubMed)
    Show all 12 references for 4356573

  2. Human Polyclonal TMEM173 Primary Antibody for EIA, FACS - ABIN955253 : Sun, Li, Chen, Chen, You, Zhou, Zhou, Zhai, Chen, Jiang: ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. in Proceedings of the National Academy of Sciences of the United States of America 2009 (PubMed)
    Show all 4 references for 955253

  3. Human Polyclonal TMEM173 Primary Antibody for WB - ABIN2783202 : Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ... in Genome research 2004 (PubMed)
    Show all 4 references for 2783202

  4. Human Monoclonal TMEM173 Primary Antibody for FACS, ICC - ABIN4899624 : Schoggins, MacDuff, Imanaka, Gainey, Shrestha, Eitson, Mar, Richardson, Ratushny, Litvak, Dabelic, Manicassamy, Aitchison, Aderem, Elliott, García-Sastre, Racaniello, Snijder, Yokoyama, Diamond et al.: Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. ... in Nature 2014 (PubMed)
    Show all 2 references for 4899624

  5. Human Polyclonal TMEM173 Primary Antibody for EIA, FACS - ABIN955254 : Zhong, Zhang, Lei, Li, Mao, Yang, Wang, Zhang, Shu: The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. in Immunity 2009 (PubMed)
    Show all 2 references for 955254

More Antibodies against TMEM173 Interaction Partners

Human Transmembrane Protein 173 (TMEM173) interaction partners

  1. both IL-6 (show IL6 Antibodies) and RIG-I (show DDX58 Antibodies) are downstream molecules of STING along the DNA sensor pathway.

  2. We discuss three newly described monogenic autoinflammatory diseases [deficiency of adenosine deaminase 2 (show CECR1 Antibodies) (DADA2), a subtype of macrophage activation syndrome (MAS (show MAS1 Antibodies)), and stimulator of interferon (show IFNA Antibodies) genes (STING)-associated vasculopathy with onset in infancy (SAVI)], discuss the possibilities of somatic mosaicism and digenic inheritance, and give an update on new concepts in pathways involved in familial Mediterranean fever (show MEFV Antibodies)

  3. Structural analysis indicates that the 3 disease-associated mutations at positions 206, 281, and 284 of the STING protein define a novel cluster of amino acids with functional importance in the regulation of type I interferon (show IFNA Antibodies) signaling

  4. a critical role of p38 (show CRK Antibodies)-mediated USP21 (show USP21 Antibodies) phosphorylation in regulating STING-mediated antiviral functions and identifies p38 (show CRK Antibodies)-USP21 (show USP21 Antibodies) axis as an important pathway that DNA virus adopts to avoid innate immunity responses.

  5. We conclude that the R71H-G230A-R293Q (HAQ) of TMEM173 is a null TMEM173 allele.

  6. Human herpesvirus 1 ICP27 interacted with TBK1 (show TBK1 Antibodies) and STING in a manner that was dependent on TBK1 (show TBK1 Antibodies) activity and the RGG motif in ICP27 and inhibited type I IFN induction through the cGAS-STING-TBK1 (show TBK1 Antibodies) pathway in human macrophages.

  7. Multivariate analysis supported TMEM173 as an independent prognostic factor.

  8. The mitochondrial damage-cGAS-STING-IRF3 (show IRF3 Antibodies) pathway is critically involved in metabolic stress-induced endothelial inflammation.

  9. These data uncover a promycobacterial role for STING-dependent OASL (show OASL Antibodies) production during Mycobacterium leprae infection that directs the host immune response toward a niche that permits survival of the pathogen.

  10. cGAs recognizes bacterial/viral DNA, and is a strong activator of STING that can further activate IRF3 (show IRF3 Antibodies) and subsequent type I interferon (show IFNA Antibodies) production. (Review)

Mouse (Murine) Transmembrane Protein 173 (TMEM173) interaction partners

  1. Yersinia YopJ negatively regulates IRF3 (show IRF3 Antibodies)-mediated antibacterial response through disruption of STING-mediated cytosolic DNA signaling.

  2. demonstrate that in colon tumor model, therapeutic anti-CD47 (show CD47 Antibodies) preferentially relies on STING-mediated DNA sensing in dendritic cells

  3. STING is a central mediator of interferon (show IFNA Antibodies) regulated inflammasome activation in Chlamydia trachomatis infection.

  4. this study shows that immune rejection of prostate cancer cells relies on Mus81 (show MUS81 Antibodies) and STING

  5. TRIF (show RNF138 Antibodies) and STING interacted directly, through their carboxy-terminal domains, to promote STING dimerization, intermembrane translocation, and signaling.

  6. We conclude that the R71H-G230A-R293Q (HAQ) of TMEM173 is a null TMEM173 allele.

  7. results show that resistance to HSV-1 in the trigeminal ganglia during acute infection is conferred in part by STING and IFN-alpha (show IFNA Antibodies)/beta signaling in both bone marrow-derived and -resident cells, which coalesce to support a robust HSV-1-specific CD8 (show CD8A Antibodies)(+) T cell response

  8. results suggest that LSm14A (show LSM14A Antibodies) plays an important role in antiviral innate and adaptive immune responses by modulating MITA level in a cell type-specific manner

  9. STING and TRIF (show RNF138 Antibodies) Contribute to Mouse Sepsis, Depending on Severity of the Disease Model

  10. Data suggest that activation of either RIG-I (show DDX58 Antibodies)/MAVS (show MAVS Antibodies) or STING pathways during acute intestinal tissue injury in mice resulted in IFN-I signaling that maintained gut (show GUSB Antibodies) epithelial barrier integrity and reduced GVHD severity.

Pig (Porcine) Transmembrane Protein 173 (TMEM173) interaction partners

TMEM173 Antigen Profile

Antigen Summary

Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.

Alternative names and synonyms associated with TMEM173

  • transmembrane protein 173 (TMEM173) antibody
  • transmembrane protein 173 (Tmem173) antibody
  • 2610307O08Rik antibody
  • ERIS antibody
  • Mita antibody
  • MPYS antibody
  • NET23 antibody
  • RGD1562552 antibody
  • STING antibody

Protein level used designations for TMEM173

transmembrane protein 173 , N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner , endoplasmic reticulum IFN stimulator , endoplasmic reticulum interferon stimulator , hMITA , hSTING , mediator of IRF3 activation , mitochondrial mediator of IRF3 activation , stimulator of interferon genes protein , MMITA , mSTING , Stimulator of interferon genes protein , mitochondrial transmembrane protein 173

606815 Canis lupus familiaris
462107 Pan troglodytes
694353 Macaca mulatta
100459760 Pongo abelii
340061 Homo sapiens
72512 Mus musculus
533661 Bos taurus
768990 Gallus gallus
100217389 Sus scrofa
498840 Rattus norvegicus
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