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sensitive to freezing3(sfr3) is a missense mutation in aminoglycoside N1-acetyltransferase. Freezing sensitivity of sfr3 appears to be due to cuticular deficiencies that develop during cold acclimation.
The gsd1 (show G6PC ELISA Kits) locus was mapped to chromosome 1, and the causal gene was identified as a new allele of Acetyl-Coenzyme A Carboxylase1 (ACC1), a gene encoding the main enzyme in cytosolic malonyl-coenzyme A synthesis.
Data suggest that the lack of cytosolic malonyl-CoA is likely to be the initial factor leading to abnormal development in acetyl-CoA carboxylase 1 mutants.
acetyl-CoA carboxylase 1 and senescence regulation in human fibroblasts involves oxidant mediated p38 MAPK (show MAPK14 ELISA Kits) activation
ACC1 and ACLY (show ACLY ELISA Kits) regulate the levels of ETV4 (show ETV4 ELISA Kits) under hypoxia via increased alpha-ketoglutarate. These results reveal that the ACC1/ACLY (show ACLY ELISA Kits)-alpha-ketoglutarate-ETV4 (show ETV4 ELISA Kits) axis is a novel means by which metabolic states regulate transcriptional output
Phospho-acetyl-CoA carboxylase protein expression correlates with tumor grade and the disease stage in gastric cancer.
ACAT1 (show ACAT1 ELISA Kits), ACACA, ALDH6A1 (show ALDH6A1 ELISA Kits) and MTHFD1 (show MTHFD1 ELISA Kits) represent novel biomarkers in adipose tissue associated with type 2 diabetes in obese individuals.
ACACA may constitute a previously unrecognized target for novel anti-breast cancer stem cell therapies.
Single nucleotide polymorphisms in the ACACA and ACLY (show ACLY ELISA Kits) genes are associated with a relative change in plasma triglycierides following fish oil supplementation.
Exercise training increased AMPKalpha1 (show PRKAA1 ELISA Kits) activity in older men, however, AMPKalpha2 (show PRKAA2 ELISA Kits) activity, and the phosphorylation of AMPK (show PRKAA1 ELISA Kits), ACC and mTOR (show FRAP1 ELISA Kits), were not affected
Metabolic regulation of invadopodia and invasion by acetyl-CoA carboxylase 1 and de novo lipogenesis.
IGF-1 (show IGF1 ELISA Kits) reduced ACCalpha phosphorylation via an ATM (show ATM ELISA Kits)/AMPK (show PRKAA1 ELISA Kits) signaling pathway and suppressed ACCalpha expression through an ERK1/2 (show MAPK1/3 ELISA Kits)
three major enzymes of the pathway, FASN (show FASN ELISA Kits), ACC, and ACLY (show ACLY ELISA Kits), are up-regulated in numerous tumor types.
Polymorphisms of the ACACA and SREBF1 (show SREBF1 ELISA Kits) genes are promising markers for pig carcass and performance traits.
Expression profiles showed that PI is the promoter driving expression of the dominant ACACA-transcript in brain.
Since the promoter region, PIII, is specific to mammary gland during lactation, the altered expression of the ACACA gene owing to the SNPs in the PIII region may influence the fatty acid composition in the milk.
results suggested that the SNPs in the promoter I region of ACACA gene are associated with variations in the fatty acid contents in longissimus dorsi muscle.
Studied a role for ACAC inactivation in meiotic resumption by testing the effect of two ACAC inhibitors, CP-640186 and Soraphen A, on mouse oocytes maintained in meiotic arrest in vitro.
AMPK (show PRKAA1 ELISA Kits)-dependent inactivation of ACC is not essential for the control of myocardial FAO and subsequent cardiac function during a variety of conditions involving AMPK (show PRKAA1 ELISA Kits)-independent and AMPK (show PRKAA1 ELISA Kits)-dependent metabolic adaptations.
Results suggest an essential role for acetyl coenzyme A carboxylase 1 (ACC1)-mediated de novo lipogenesis as a regulator of CD8 (show CD8A ELISA Kits)(+) T cell expansion.
the stimulation of fatty acid oxidation by modulating the AMPK (show PRKAA1 ELISA Kits)-ACC-CPT-1 (show CPT1A ELISA Kits) pathway may be part of a protective mechanism against saturated free fatty acids that drive podocyte death.
our data suggest that renin (show REN ELISA Kits) synthesis and secretion are regulated by AMPK (show PRKAA1 ELISA Kits) and coupled to metabolism by phosphorylation of ACC1.
analysis of mRNA abundance and expression of SLC27A, ACC, SCD (show SCD ELISA Kits), FADS, LPIN, INSIG, and PPARGC1 (show PPARGC1A ELISA Kits) gene isoforms in mouse mammary glands during the lactation cycle
A biotin analog inhibits acetyl-CoA carboxylase activity and adipogenesis
Expression of the isoenzyme of Acc1 is mediated by MyoD (show MYOD1 ELISA Kits) and MRF4 (show MYF6 ELISA Kits) is differentially affected by retinoic acid receptor (show RARA ELISA Kits) and retinoid X receptor (show RXRB ELISA Kits).
Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal.
when fed fat-free (show VPS51 ELISA Kits) diet for 10 days, there was significant up-regulation of PPARgamma (show PPARG ELISA Kits) and several enzymes in the lipogenic pathway in the liver of liver-specific ACC1 knockout mice compared with the WT mice
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
acetyl-Coenzyme A carboxylase alpha
, acetyl-CoA carboxylase 1
, acetyl-coenzyme A carboxylase alpha
, acetyl-CoA carboxylase-alpha
, acetyl-CoA carboxylase
, acetyl coenzyme A carboxylase alpha
, acetyl-CoA carboxylase 265