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Variants of ADIPOR2 could be a determinant for higher FFA levels, and among Chinese Han population, carriers of the CT and TT genotypes for rs2370055 even with normal glucose levels may have significantly higher insulin (show INS Proteins) resistance susceptibility.
We conclude that the PAQR-2 and AdipoR2 proteins share an evolutionarily conserved function that maintains membrane fluidity in the presence of exogenous saturated fatty acids.
Renoprotection of adiponectin is associated with improvement of the endothelial dysfunction, reduction of oxidative stress, and upregulation of endothelial nitric oxide synthase (show NOS3 Proteins) expression through activation of adenosine 5'-monophosphate-activated protein kinase (show CDK7 Proteins) by AdipoR1 (show ADIPOR1 Proteins) and activation of peroxisome proliferator-activated receptor (show PPARD Proteins) (PPAR)-alpha (show PPARA Proteins) signaling pathway by AdipoR2. [review]
crystal structure of ADIPOR2 bound to a FFA molecule and show that ADIPOR2 possesses intrinsic basal ceramidase activity that is enhanced by adiponectin
Adiponectin stimulates cPLA2 and COX-2 expression via AdipoR1/2-dependent activation of PKC/NADPH oxidase/mitochondria resulting in ROS accumulation, p300 phosphorylation, and histone H4 acetylation.
These results indicate that miR (show MLXIP Proteins)-150 can attenuate oxidized low-density lipoprotein - induced lipid accumulation in macrophages via promotion of cholesterol efflux. The suppressive effects of miR (show MLXIP Proteins)-150 on macrophage foam cell formation are mediated through targeting of AdipoR2.
Decreased expression of ADIPOR2 is associated with polycystic ovary syndrome.
Strong Functional Association of adipor2 and cdh13 with adipoq
PCR results showed expression of adiponectin, AdipoR1 (show ADIPOR1 Proteins), AdipoR2, follicle-stimulating hormone receptor (FSHR (show FSHR Proteins)), and luteinizing hormone receptor (LHR (show LHCGR Proteins)) in granulosa cells (GCs (show GCLC Proteins)). After controlling body mass index (BMI) values, qRT-PCR demonstrated a decreased expression of adiponectin system in GCs (show GCLC Proteins) of polycystic ovary syndromepatients compared to those in controls
Endometriotic stromal cell proliferation is linked to increased expression of AdipoR2 (and AdipoR1 (show ADIPOR1 Proteins)) gene receptor expression.
macrophage polarization is a key determinant regulating AdipoR expression and differential APN (show ANPEP Proteins)-mediated macrophage inflammatory responses
AdipoR1 (show ADIPOR1 Proteins), but not AdipoR2 deficiency, leads to diet-induced metabolic dysfunction, revealing that these receptors have highly divergent roles in vascular and metabolic homeostasis
Data suggest GnRH (gonadotropin-releasing hormone) neurons in forebrain express AdipoR2 (not AdipoR1); adiponectin/AdipoR2 signal transduction via protein kinase C zeta down-regulates neurotransmission in subpopulation of GnRH neurons.
These results prove that elevation of adiponectin and/or adipoR2 expression via gene transfer is an effective approach in managing obesity epidemics.
APN (show ANPEP Proteins), AdipoR1 (show ADIPOR1 Proteins), and AdipoR2 exist in human and mouse retinas and retinal APN (show ANPEP Proteins) and AdipoR1 (show ADIPOR1 Proteins) protein levels are elevated in type 1 diabetes mellitus mice.
Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (show INS Proteins) resistance and improves adipoR1 (show ADIPOR1 Proteins)-2/APPL1 (show APPL1 Proteins) protein levels in the hepatic, adipose, and skeletal muscle tissue.
Human biosynthetic insulin (show INS Proteins) had little or no effect in the regulation of AdipoR1 (show ADIPOR1 Proteins) expression in 3T3-L1 cells, but significantly up-regulated AdipoR2 mRNA level in a biphasic manner.
Gene expression of adiponectin and AdipoR1 (show ADIPOR1 Proteins)/AdipoR2 receptors gradually increases during the wound healing process.
The messenger RNA expression levels of hepatic adiponectin receptor (AdipoR)-1 (show ADIPOR1 Proteins) and AdipoR2 and skeletal muscular AdipoR1 (show ADIPOR1 Proteins) were up-regulated by tiliroside treatment.
This study demonistrated that AdipoR2 is expressed on warm sensitive neurons of the hypothalamic preoptic area and contribute to central hyperthermic effects of adiponectin.
The ADIPOR2 c.*112G>A SNP was associated with the total number of piglets born and litter weight at weaning.
This study demonstrated the presence of adiponectin and its receptors in the uteri, conceptuses, and trophoblasts of pregnant pigs and that the local adiponectin system is dependent on the stage of pregnancy.
study demonstrated that adiponectin and adiponectin receptors 1 and 2 messenger RNAs and proteins are present in the porcine hypothalamus and that their expression levels are determined by the pig's endocrine status related to the oestrous cycle
This study demonstrated the presence of adiponectin, AdipoR1 and AdipoR2 genes and proteins in the porcine uterus and the effect of the stage of the oestrous cycle on the expression of the adiponectin system.
Data indicate that AdipoR1 and AdipoR2 mRNAs and proteins are present in the porcine pituitary and that adiponectin receptors expression is dependent on endocrine status of the animals.
The cloning and characterization of adiponectin, ADIPOR1 (show ADIPOR1 Proteins), and ADIPOR2 are reported.
Insulin regulates the expression of adiponectin and adiponectin receptors in porcine adipocytes.
Low level expression of adiponectin mRNA was found in all areas of bovine mammary gland tissues examined. AdipoR1 (show ADIPOR1 Proteins) and AdipoR2 mRNAs were also detected in mammary tissues and their expression was particularly prominent in the parenchyma and cistern.
The physiologic status of the ovary has significant effects on the natural expression patterns of adiponectin and its receptors in follicular and luteal cells of bovine ovary.
Adiponectin and adiponectin receptor genes are coexpressed during zebrafish embryogenesis and regulated by food deprivation
The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA\; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003
adiponectin receptor 2
, adiponectin receptor protein 2
, adiponectin receptor protein 2-like protein
, adiponectin receptor protein 2-like
, progestin and adipoQ receptor family member II
, adiponectin receptor type II